Table of Contents

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 6 0.0093 [0.0019,0.0168]
FL GAMBL with Crouch 1,189 7 0.0059 [0.0015,0.0102]
FL BC 379 2 0.0053 [0,0.0126]
FL Kalmbach 164 3 0.0183 [0,0.0388]
FL Crouch 547 1 0.0018 [0,0.0054]
FL FL_ICGC 99 1 0.0101 [0,0.0298]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.4497 0 1.0000
FL 1.6809 0 1.0000
DLBCL 0.0000 0 0.9986

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Expression

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References

1.
Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T. Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Advances. 2023;7:5524–5539.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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