ACTG1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas.
Mutation tier
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 1-a | high-confidence DLBCL gene, hypermutated |
| FL | 2-a | relevance in FL not firmly established, hypermutated |
Mutation incidence
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 5.35 |
| DLBCL | Schmitz cohort | NA |
| DLBCL | Reddy cohort | NA |
| DLBCL | Chapuy cohort | NA |
| FL | GAMBL genomes | 3.00 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 2.063 | 8.011 |
| DLBCL | Yes | No | 2.125 | 0.000 |
| FL | Yes | No | 8.128 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr17 | 79478289 | 79479959 | intron | NA |
View all variants in GenomePaint hg19 or hg38
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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