Table of Contents
ACTG1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas. The function of mutations in ACTB and ACTG1 have not yet been determined.1
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established2 |
 |
2 | relevance in MZL not firmly established3 |
 |
2 | relevance in FL not firmly established4 |
 |
1 | aSHM target and high-confidence DLBCL gene4 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
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Mutation pattern and selective pressure estimates
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aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr17 | 79478289 | 79479959 | intron | NA |
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Expression
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References
1.
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Prevalence of Cytoplasmic Actin Mutations in Diffuse
Large B-Cell Lymphoma and Multiple Myeloma: A
Functional Assessment Based on Actin Three-Dimensional
Structures. Int J Mol Sci. 2020 Apr 27;21(9):3093. PMCID: PMC7247664
2.
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3.
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4.
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AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo
de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann
ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C,
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JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A,
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Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining
consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R.
Mutational mechanisms shaping the coding and noncoding genome of
germinal center derived B-cell lymphomas.
Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491