ALPK2
History
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timeline
title Publication timing
2019-09-26 : Panea : BL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 3.93 |
| BL | Thomas cohort | 5.10 |
| BL | Panea cohort | 9.90 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.951 | 0 |
| DLBCL | No | No | 0.000 | 0 |
| FL | No | No | 1.538 | 0 |
ALPK2 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr18 | 56203836 | C>T | V1195M |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
ALPK2 Expression
Representative Mutations
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☆ ☆ ## References 1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J,
Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao
N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R,
Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R,
Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A,
Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne
R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape
of Burkitt lymphoma subtypes. Blood. 2019;
