Table of Contents

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.68
DLBCL Schmitz cohort 4.26
DLBCL Reddy cohort 3.80
DLBCL Chapuy cohort 2.14

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.6218 15.2126 1.0000
FL 0.4172 0.0000 1.0000
DLBCL 0.0000 0.0000 0.9986

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Expression

Representative Mutations1

★ ☆ ☆ ☆ ☆

★ ☆ ☆ ☆ ☆

All Mutations1

Reddy_1016T Reddy_2045T Reddy_2144T Reddy_2153T Reddy_2262T Reddy_2297T Reddy_2471T Reddy_2479T Reddy_2534T Reddy_2567T Reddy_2616T Reddy_2629T Reddy_2635T Reddy_2658T Reddy_2675T Reddy_2715T Reddy_2775T Reddy_2791T Reddy_2808T Reddy_2820T Reddy_2827T Reddy_2838T Reddy_2936T Reddy_2999T Reddy_3407T Reddy_3409T Reddy_3419T Reddy_3438T Reddy_3472T Reddy_3525T Reddy_3545T Reddy_3549T Reddy_3552T Reddy_3584T Reddy_3631T Reddy_3667T Reddy_3691T Reddy_3700T Reddy_3709T Reddy_3715T Reddy_3725T Reddy_3819T Reddy_3883T Reddy_3885T Reddy_3896T Reddy_3913T Reddy_3916T Reddy_3924T Reddy_3943T Reddy_3945T Reddy_3952T Reddy_3977T Reddy_705T

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References

1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841
2.
Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI, Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL, Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 2013;110:1398–1403. PMCID: PMC3557051

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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