ARHGEF1
Relevance tier by entity
| Entity |
Tier |
Description |
 |
2 |
relevance in BL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity |
source |
frequency (%) |
| BL |
GAMBL genomes+capture |
3.93 |
| BL |
Thomas cohort |
2.00 |
| BL |
Panea cohort |
NA |
Mutation pattern and selective pressure estimates
| Entity |
aSHM |
Significant selection |
dN/dS (missense) |
dN/dS (nonsense) |
| BL |
No |
No |
2.954 |
0.000 |
| DLBCL |
No |
No |
2.662 |
9.372 |
| FL |
No |
No |
3.865 |
0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
ARHGEF1 Expression
References
- Muppidi J, Schmitz R, Green JA, Green JA, Xiao W, Larsen AB, Braun S, An J, Xu Y, Rosenwald A, Ott G, Gascoyne R, Rimsza L, Campo E, Jaffe E, Delabie J, Smeland E, Braziel R, Tubbs R, Cook J, Weisenburger D, Chan W, Vaidehi N, Staudt L, Cyster J. Loss of signaling via Gα13 in germinal center B cell-derived lymphoma. Nature. 2014;516:254–258.