ARID1A

Overview

ARID1A (AT-rich interactive domain-containing protein 1A) is a gene that encodes a subunit of the SWI/SNF chromatin remodeling complex, which is involved in regulating DNA accessibility. Mutations in ARID1A are implicated in various cancers, including B-cell lymphomas. They are the most abundant in Burkitt lymphoma but also occur in FL and, to a lesser extent, DLBCL.

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene
	1	high-confidence MZL gene
	1	high-confidence BL gene
	1	high-confidence DLBCL gene
	1	high-confidence FL gene

Mutation incidence in large cohorts

Entity	source	frequency (%)
BL	GAMBL genomes+capture	28.64
BL	Thomas cohort	36.00
BL	Panea cohort	19.80
DLBCL	GAMBL genomes	8.80
DLBCL	Schmitz cohort	8.94
DLBCL	Reddy cohort	4.40
DLBCL	Chapuy cohort	4.27
FL	GAMBL genomes	12.47

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	Yes	3.218	130.201
DLBCL	No	Yes	2.364	38.689
FL	No	Yes	3.794	248.722

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

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