ATM
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 1 | high-confidence DLBCL gene |
| MCL | 1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 6.88 |
| DLBCL | Schmitz cohort | 5.53 |
| DLBCL | Reddy cohort | 5.91 |
| DLBCL | Chapuy cohort | 4.70 |
| MCL | GAMBL genomes | 45.02 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.461 | 0.000 |
| DLBCL | No | No | 3.529 | 5.446 |
| FL | No | No | 1.679 | 6.201 |
[!NOTE] First described in DLBCL in 2017 by Reddy A. First described in MCL in 2013 by Beà S
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## ATM
Expression 
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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