Table of Contents

Overview

Mutations in this gene were first described in BL in 2019 by Grande et al.1

Experimental Evidence

Driver mutations affecting this gene in BL have been experimentally demonstrated to cause a reduction or loss of function (LOF).hunterNFkBSubunitCRel2016?

Relevance tier by entity

Cannot include /table1_BACH2 - does not exist yet

Mutation incidence in large patient cohorts (GAMBL reanalysis)

BL

Cannot include /BL_BACH2.md - does not exist yet

Mutation pattern and selective pressure estimates

Cannot include /dnds_BACH2.md - does not exist yet

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr6 90981034 91016134 TSS NA

Cannot include /browser_BACH2.md - does not exist yet

Expression

Cannot include /mermaid_BACH2.md - does not exist yet

References

1.
Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019;133(12):1313–1324. PMCID: PMC6428665

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.