[BCL11A]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 2 |
| DLBCL | 1 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 2.54 |
| BL | Thomas cohort | 1.70 |
| BL | Panea cohort | 5.90 |
| DLBCL | GAMBL genomes | 3.60 |
| DLBCL | Schmitz cohort | 4.50 |
| DLBCL | Reddy cohort | 1.60 |
| DLBCL | Chapuy cohort | 3.40 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 4.455 | 0.000 |
| DLBCL | Yes | Yes | 5.279 | 69.578 |
| FL | Yes | No | 1.180 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr2 | 60773789 | 60783486 | TSS | active_promoter |
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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