Table of Contents

Overview

BCL6 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. Although common, particularly in DLBCL, the function of many of these mutations remains unclear but some have been shown to affect the regulation of BCL6 expression. The role of BCL6 missense mutations, seen over 9% of patients remains unclear.

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

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Mutation pattern and selective pressure estimates

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aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr3 187458526 187464632 TSS NA
chr3 187615533 187625659 Intergenic-1 NA
chr3 187625659 187638101 Intergenic-2 NA
chr3 187657518 187665996 Intergenic-3 NA
chr3 187675741 187690717 Intergenic-4 NA
chr3 187690717 187705000 Intergenic-5 NA

BCL6 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr3 187443373 G>A R585W
chr3 187443370 G>A P586S
chr3 187443369 G>A P586L
chr3 187443367 C>T A587T
chr3 187443366 G>T A587D
chr3 187443366 G>C A587G
chr3 187443345 C>T R594Q
chr3 187443342 A>T I595N

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Expression

Representative Mutations

BL

Rating ★ ★ ★ ★ ☆

All Mutations

BL

1090 747

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References

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Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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