Table of Contents

Overview

BCL7A protein interacts with components of the SWI/SNF chromatin remodeling complex, implicating it in chromatin remodeling processes essential for normal cellular function.1 Mutations in the BCL7A gene have been identified in diffuse large B-cell lymphoma (DLBCL) and other B-cell lymphomas, implicating this gene in the pathogenesis of these cancers. Importantly, BCL7A is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. Due to the presence of some loss-of-function mutations, BCL7A has been described as a tumour-suppressor gene in DLBCL.2 The rate of DLBCLs with biallelic loss of this locus remains unclear.

Experimental Evidence

Driver mutations affecting this gene in BL/DLBCL/FL have been experimentally demonstrated to cause a reduction or loss of function (LOF).2

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 91 0.0836 [0.0671,0.1]
DLBCL GAMBL with Reddy 2,088 175 0.0838 [0.0719,0.0957]
DLBCL BC 231 25 0.1082 [0.0682,0.1483]
DLBCL Dana-Farber 303 15 0.0495 [0.0251,0.0739]
DLBCL NCI 470 50 0.1064 [0.0785,0.1343]
DLBCL Reddy 999 84 0.0841 [0.0669,0.1013]
DLBCL DLBCL_ICGC 85 1 0.0118 [0,0.0347]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 83 0.1293 [0.1033,0.1552]
FL GAMBL with Crouch 1,189 188 0.1581 [0.1374,0.1789]
FL BC 379 57 0.1504 [0.1144,0.1864]
FL Kalmbach 164 24 0.1463 [0.0922,0.2004]
FL Crouch 547 105 0.1920 [0.159,0.225]
FL FL_ICGC 99 2 0.0202 [0,0.0479]

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 17 0.0432 [0.0207,0.0657]
BL GAMBL without ICGC/Zhou 320 21 0.0654 [0.0383,0.0924]
BL GAMBL with Panea 410 23 0.0463 [0.0261,0.0665]
BL BLGSP 219 15 0.0685 [0.035,0.1019]
BL Zhou/ICGC 90 2 0.0222 [0,0.0527]
BL Panea 101 6 0.0594 [0.0133,0.1055]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 7.6653 32.1054 0
FL 8.7885 29.4846 0
DLBCL 2.1542 8.8483 0

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr12 122456912 122464036 TSS poised_promoter

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Expression

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References

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Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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