BL genes

Origins of BL genes

--- config: sankey: showValues: false linkColor: target width: 800 height: 1000 nodeAlignment: right --- sankey-beta Grande 2019, BL Tier 1, 9 Grande 2019, BL Tier 2, 4 Richter 2012, BL Tier 1, 5 Burkhardt 2022, BL Tier 2, 25 Schmitz 2012, BL Tier 1, 3 Schmitz 2012, BL Tier 2, 16 Love 2012, BL Tier 1, 3 Love 2012, BL Tier 2, 56 Muppidi 2014, BL Tier 1, 1 Muppidi 2014, BL Tier 2, 2 Panea 2019, BL Tier 1, 4 Panea 2019, BL Tier 2, 46 Thomas 2023, BL Tier 1, 2 Thomas 2023, BL Tier 2, 3 BL, panel, 25 panel, Burkhardt 2022, 25 BL, WGS, 13 WGS, Grande 2019, 13 BL, RNA-seq/WGS/exome, 5 RNA-seq/WGS/exome, Richter 2012, 5 BL, exome, 59 exome, Love 2012, 59 BL, RNA-seq, 19 RNA-seq, Schmitz 2012, 19 BL, Sanger, 3 Sanger, Muppidi 2014, 3 BL, RNA-seq/exome, 50 RNA-seq/exome, Panea 2019, 50 BL, WGS, 5 WGS, Thomas 2023, 5
## Tier 1 BL genes

29 total

Gene Tier Relevant references
ARID1A 1 Zhang et al. 2013; Love et al. 2012; Krysiak et al. 2017
BCL7A 1, aSHM Grande et al. 2019; Krysiak et al. 2017; Arthur et al. 2018
BMP7 1 Panea et al. 2019
CCND3 1 Richter et al. 2012; Morin et al. 2011
CHD8 1 Grande et al. 2019; Reddy et al. 2017
DDX3X 1 Schmitz et al. 2018, 2012
EIF4A1 1 Panea et al. 2019
EPPK1 1 Panea et al. 2019
FBXO11 1 Richter et al. 2012; Hübschmann et al. 2021
FOXO1 1 Schmitz et al. 2012; Morin et al. 2011
GNA13 1 Morin et al. 2011; Love et al. 2012
GNAI2 1 Grande et al. 2019; Morin et al. 2013
HNRNPU 1, aSHM Panea et al. 2019; Reddy et al. 2017
ID3 1 Schmitz et al. 2012; Richter et al. 2012
KMT2D 1 Grande et al. 2019; Morin et al. 2011; Beà et al. 2013
MYC 1, aSHM L. Pasqualucci et al. 2001; Johnston and Carroll 1992
P2RY8 1 Lohr et al. 2012; Muppidi et al. 2014
PHF6 1 Reddy et al. 2017; Thomas et al. 2023
PTEN 1 Love et al. 2012
RFX7 1 Grande et al. 2019
RHOA 1 Richter et al. 2012
SIN3A 1 Grande et al. 2019
SMARCA4 1 Richter et al. 2012; Zhang et al. 2013; Nadeu et al. 2020; Krysiak et al. 2017
TCF3 1 Schmitz et al. 2012
TCL1A 1, aSHM Grande et al. 2019
TFAP4 1 Grande et al. 2019
TP53 1 Morin et al. 2011; Wilda et al. 2004; Beà et al. 2013
USP7 1 Grande et al. 2019
WNK1 1 Thomas et al. 2023; Hübschmann et al. 2021

Tier 2 BL genes

157 total

Gene Tier Relevant references
ACAD9 2 Love et al. 2012
ACE 2 Love et al. 2012
ADAMTS5 2 Burkhardt et al. 2022
ADNP 2 Burkhardt et al. 2022
AGO4 2 Burkhardt et al. 2022
ALPK2 2 Panea et al. 2019
ARHGEF1 2 Muppidi et al. 2014
ATP2C2 2 Love et al. 2012
BACH2 2, aSHM Grande et al. 2019
BCL2 2, aSHM Tanaka et al. 1992; Burkhardt et al. 2022; Morin et al. 2011
BCL6 2, aSHM Morin et al. 2011; Love et al. 2012
BRAF 2 Love et al. 2012; Tiacci et al. 2011
BRD4 2 Love et al. 2012
BTG1 2, aSHM Morin et al. 2011; Burkhardt et al. 2022
BTG2 2, aSHM Love et al. 2012; Morin et al. 2011
C16orf48 2 Schmitz et al. 2012
C6orf27 2 Love et al. 2012
CAD 2 Love et al. 2012
CARD11 2 Morin et al. 2011; Panea et al. 2019; Wu et al. 2016; Lenz et al. 2008
CARD4 2 Love et al. 2012
CCNF 2 Abate et al. 2015
CCT6B 2 Love et al. 2012
CD79A 2 Burkhardt et al. 2022
CD79B 2 Panea et al. 2019; Morin et al. 2011
CD83 2, aSHM Morin et al. 2013; Russler-Germain et al. 2023; Panea et al. 2019
CDC73 2 Love et al. 2012; Reddy et al. 2017
CDH17 2 Love et al. 2012
CDKN2A 2 Grande et al. 2019; Morin et al. 2013
CDKN2C 2 Thomas et al. 2023
CHD4 2 Burkhardt et al. 2022
COL4A2 2 Love et al. 2012
CPXM2 2 Burkhardt et al. 2022
CREBBP 2 Laura Pasqualucci, Dominguez-Sola, et al. 2011; Love et al. 2012
CTCF 2 Panea et al. 2019
CXCR4 2, aSHM Panea et al. 2019; Khodabakhshi et al. 2012; Krysiak et al. 2017
CYB5D1 2 Love et al. 2012
CYP4F22 2 Love et al. 2012
DHCR7 2 Schmitz et al. 2012
DLGAP1 2 Love et al. 2012
DNMT1 2 Panea et al. 2019
DTX1 2, aSHM Schmitz et al. 2018; Panea et al. 2019
E2F2 2 Burkhardt et al. 2022
EBF1 2, aSHM Thomas et al. 2023; Bohle et al. 2013
EDNRB 2 Burkhardt et al. 2022
EHD1 2 Thomas et al. 2023
EIF2C4 2 Love et al. 2012
ELP2 2 Schmitz et al. 2012
EML2 2 Love et al. 2012
ENTPD3 2 Love et al. 2012
EP300 2 Laura Pasqualucci, Dominguez-Sola, et al. 2011; Panea et al. 2019
EPHB2 2 Love et al. 2012
ERAP1 2 Burkhardt et al. 2022
ETS1 2, aSHM Morin et al. 2011; Panea et al. 2019
EXOSC6 2 Schmitz et al. 2012
EZH2 2 Love et al. 2012; Morin et al. 2010
FAM129B 2 Love et al. 2012
FGFR3 2 Love et al. 2012
FLYWCH1 2 Schmitz et al. 2012
FTCD 2 Love et al. 2012
FZD3 2 Panea et al. 2019
GGTLA4 2 Love et al. 2012
GRB2 2 Laura Pasqualucci, Trifonov, et al. 2011; Panea et al. 2019
GRIK5 2 Love et al. 2012
GTSE1 2 Schmitz et al. 2012
HIST1H1C 2, aSHM Morin et al. 2011; Panea et al. 2019
HIST1H1E 2, aSHM Grande et al. 2019; Morin et al. 2013; Krysiak et al. 2017
HIST1H2AG 2, aSHM Panea et al. 2019; Morin et al. 2013; Krysiak et al. 2017
HIST1H2AM 2, aSHM Panea et al. 2019; Krysiak et al. 2017
HIST1H2BK 2, aSHM Panea et al. 2019
HIST1H3D 2, aSHM Panea et al. 2019
HIST1H3H 2, aSHM Panea et al. 2019
HIST1H3I 2, aSHM Krysiak et al. 2017; Panea et al. 2019
HIST1H3J 2, aSHM Panea et al. 2019
HIST1H4J 2, aSHM Panea et al. 2019
HLA-A 2
HLA-B 2
HLA-DMB 2
HLA-DQB1 2 Burkhardt et al. 2022
ICK 2 Love et al. 2012
IGLL5 2, aSHM Panea et al. 2019; Russler-Germain et al. 2023
IKZF3 2, aSHM Morin et al. 2013; Panea et al. 2019
IRF8 2, aSHM Panea et al. 2019; Morin et al. 2011
ITPR3 2 Love et al. 2012
KANK2 2 Schmitz et al. 2012
KCNK10 2 Panea et al. 2019
KIFC3 2 Love et al. 2012
KLHL26 2 Burkhardt et al. 2022
KLHL6 2, aSHM Morin et al. 2011; Panea et al. 2019
KMT2C 2 Zhou et al. 2019; Zhang et al. 2013; Zhang et al. 2014
LTB 2, aSHM Chapuy et al. 2018; Panea et al. 2019
MAP3K6 2 Love et al. 2012
MCL1 2 Panea et al. 2019; Reddy et al. 2017
MIR142 2, aSHM Grande et al. 2019; Kwanhian et al. 2012
MKI67 2 Schmitz et al. 2012; Russler-Germain et al. 2023
MME 2 Panea et al. 2019
MTOR 2 Zhang et al. 2013; Panea et al. 2019
MYH10 2 Love et al. 2012
MYO18A 2 Schmitz et al. 2012
NBEAL1 2 Love et al. 2012
NCOR2 2 Schmitz et al. 2012
NOA1 2 Burkhardt et al. 2022
NOTCH1 2 Beà et al. 2013; Love et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011
NOTCH2 2 Trøen et al. 2008; Beà et al. 2013; Panea et al. 2019
NRXN2 2 Love et al. 2012
P2RY2 2 Love et al. 2012
PABPC4L 2 Panea et al. 2019
PC 2 Love et al. 2012
PCBP1 2 Schmitz et al. 2012
PCDHA11 2 Panea et al. 2019
PDCD11 2 Schmitz et al. 2012
PDZRN3 2 Panea et al. 2019
PIK3R1 2 Panea et al. 2019; Zhang et al. 2013
PIM1 2, aSHM L. Pasqualucci et al. 2001; Burkhardt et al. 2022
PLCG2 2 Panea et al. 2019
POLRMT 2 Love et al. 2012
POR 2 Love et al. 2012
PPP6R2 2 Burkhardt et al. 2022
PREX1 2 Burkhardt et al. 2022
PRSS22 2 Love et al. 2012
PTPRN 2 Love et al. 2012
PXDNL 2 Panea et al. 2019
RAC2 2 Panea et al. 2019; Hübschmann et al. 2021
RANBP6 2 Love et al. 2012
RBP3 2 Love et al. 2012
RET 2 Love et al. 2012
REV3L 2 Burkhardt et al. 2022
RNF144B 2 Panea et al. 2019
RPL10 2 Burkhardt et al. 2022
S1PR2 2, aSHM Muppidi et al. 2014; Morin et al. 2011
SAL3 2 Burkhardt et al. 2022
SALL3 2 Zhang et al. 2014; Love et al. 2012
SAPS2 2 Love et al. 2012
SBF1 2 Love et al. 2012
SF3B1 2 Love et al. 2012
SHANK1 2 Love et al. 2012
SLC29A2 2 Love et al. 2012
SNTB2 2 Panea et al. 2019
SP3 2 Panea et al. 2019
SYNCRIP 2 Panea et al. 2019
SYNGAP1 2 Love et al. 2012
TBC1D9B 2 Love et al. 2012
TET2 2 Albuquerque et al. 2017; Panea et al. 2019
TIGD6 2 Love et al. 2012
TOP2A 2 Schmitz et al. 2012
TPST2 2 Love et al. 2012
TTN 2 Burkhardt et al. 2022
VWA7 2 Burkhardt et al. 2022
WDR7 2 Panea et al. 2019
WDR90 2 Schmitz et al. 2012
WHAMM 2 Schmitz et al. 2012
WNK2 2 Panea et al. 2019
YY1AP1 2 Schmitz et al. 2012
ZAN 2 Burkhardt et al. 2022
ZBTB7A 2 Reddy et al. 2017; Burkhardt et al. 2022
ZFP36L1 2, aSHM Panea et al. 2019; Morin et al. 2011
ZNF229 2 Love et al. 2012
ZNF85 2 Burkhardt et al. 2022

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