Origins of BL genes

Tier 1 BL genes

28 total

Gene Summary First BL study Other entities QC result
ARID1A Tier 1 GE1, FE2 Love et al 3,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c?,wienandGenomicAnalysesFlowsorted2019b?
BACH2 Tier 1 GE4 Grande et al
BCL7A Tier 1 GE4, FEbalinas-gaviraFrequentMutationsAminoterminal2020b? Grande et al 5,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
BMP7 Tier 1 GE6 Panea et al
CCND3 Tier 1 GErichterRecurrentMutationID32012a?, FE7 Richter et al 5,8,9
CHD8 Tier 1 GE4 Grande et al
DDX3X Tier 1 GE7, FE10, CEkizhakeyilDDX3XLossAdverse2021? Schmitz et al 11,mottokIntegrativeGenomicAnalysis2019b?
FBXO11 Tier 1 GErichterRecurrentMutationID32012a?, FE12 Richter et al 13,hubschmannMutationalMechanismsShaping2021b?
FOXO1 Tier 1 GE7, FE14, CE14 Schmitz et al 5,dunsCharacterizationDLBCLPMBL2021b?
GNA13 Tier 1 GE1, FEmuppidiLossSignalingGa132014b? Love et al 5,reichelFlowSortingExome2015a?
GNAI2 Tier 1 GE4 Grande et al 15
HNRNPU Tier 1 GE6 Panea et al 11
ID3 Tier 1 GErichterRecurrentMutationID32012a?, FErichterRecurrentMutationID32012a? Richter et al 7,spinaGeneticsNodalMarginal2016b?
KMT2D Tier 1 GE4, FE16, CE17 Grande et al 5,8,18,rossiCodingGenomeSplenic2012c?
MYC Tier 1 GE19, FE20, CE21 Johnston et al 9,dunsCharacterizationDLBCLPMBL2021b?,pasqualucciHypermutationMultipleProtooncogenes2001a?
P2RY8 Tier 1 GEmuppidiLossSignalingGa132014b?, FEmuppidiLossSignalingGa132014b? Muppidi et al lohrDiscoveryPrioritizationSomatic2012a?
PHF6 Tier 1 GE22 Thomas et al 11
PTEN Tier 1 GE1 Love et al 11
RFX7 Tier 1 GE4 Grande et al
RHOA Tier 1 GErichterRecurrentMutationID32012a?, FE23 Richter et al 3
SIN3A Tier 1 GE4 Grande et al chapuyMolecularSubtypesDiffuse2018b?,rossiCodingGenomeSplenic2012c?
SMARCA4 Tier 1 GErichterRecurrentMutationID32012a?, FE24 Richter et al 11,krysiakRecurrentSomaticMutations2017b?,nadeuGenomicEpigenomicInsights2020b?
TCF3 Tier 1 GE7, FE7 Schmitz et al
TCL1A Tier 1 GE4 Grande et al 11
TFAP4 Tier 1 GE4 Grande et al
TP53 Tier 1 GE25, FErowhTp53DeletionLineage2011? Wilda et al 5,18,lohrDiscoveryPrioritizationSomatic2012a?,rossiCodingGenomeSplenic2012c?,tiacciPervasiveMutationsJAKSTAT2018b?
USP7 Tier 1 GE4 Grande et al 26
WNK1 Tier 1 GE22 Thomas et al 9,hubschmannMutationalMechanismsShaping2021b?

Tier 2 BL genes

76 total

Gene Summary First BL study Other entities QC result
ADAMTS5 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
ADNP Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
AGO4 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
ARHGEF1 Tier 2 GEmuppidiLossSignalingGa132014b? Muppidi et al
BCL2 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b?, FE27 Burkhardt et al 5,28,sarkozyMutationalLandscapeGray2021a?
BCL6 Tier 2 GE1, FE27 Love et al 5 PASS
BTG1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b?, FEmlynarczykBTG1MutationYields2023b? Burkhardt et al 5,sarkozyMutationalLandscapeGray2021a?
C16orf48 Tier 2 GE7 Schmitz et al
CARD4 Tier 2 GE1 Love et al PASS
CCNF Tier 2 GEabateDistinctViralMutational2015a? Abate et al 3
CD79A Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al rossiCodingGenomeSplenic2012c?
CD83 Tier 2 GE6 Panea et al 15,dunsCharacterizationDLBCLPMBL2021b?,russler-germainMutationsAssociatedProgression2023b? PASS
CDC73 Tier 2 GE1 Love et al 11 PASS
CDKN2A Tier 2 GE4, CEjardinDiffuseLargeBcell2010a? Grande et al 15,spinaGeneticsNodalMarginal2016b?
CDKN2C Tier 2 GE22 Thomas et al
CHD4 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
CPXM2 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
CREBBP Tier 2 GE1, FEpasqualucciInactivatingMutationsAcetyltransferase2011a? Love et al 13,dunsCharacterizationDLBCLPMBL2021b?,pasqualucciInactivatingMutationsAcetyltransferase2011a? PASS
CXCR4 Tier 2 GE6 Panea et al 29,krysiakRecurrentSomaticMutations2017b? PASS
DHCR7 Tier 2 GE7 Schmitz et al
E2F2 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
EBF1 Tier 2 GE22 Thomas et al 30,reichelFlowSortingExome2015a?
EDNRB Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
EHD1 Tier 2 GE22 Thomas et al
EIF4A1 Tier 2 GE6 Panea et al
ELP2 Tier 2 GE7 Schmitz et al
EPPK1 Tier 2 GE6 Panea et al
ERAP1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
EXOSC6 Tier 2 GE7 Schmitz et al
EZH2 Tier 2 GE1, FEyapSomaticMutationsEZH22011b? Love et al morinSomaticMutationsAltering2010a?,mottokIntegrativeGenomicAnalysis2019b? PASS
FLYWCH1 Tier 2 GE7 Schmitz et al
GGTLA4 Tier 2 GE1 Love et al PASS
GTSE1 Tier 2 GE7 Schmitz et al
HIST1H1E Tier 2 GE4 Grande et al krysiakRecurrentSomaticMutations2017b?,lohrDiscoveryPrioritizationSomatic2012a?,reichelFlowSortingExome2015a?
HIST1H3D Tier 2 GE6 Panea et al PASS
HIST1H3I Tier 2 GE6 Panea et al krysiakRecurrentSomaticMutations2017b? PASS
HIST1H4J Tier 2 GE6 Panea et al mottokIntegrativeGenomicAnalysis2019b? PASS
HLA-DQB1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
IGLL5 Tier 2 GE6 Panea et al 8,chapuyMolecularSubtypesDiffuse2018b?,russler-germainMutationsAssociatedProgression2023b? PASS
IKZF3 Tier 2 GE6 Panea et al 5 PASS
IRF8 Tier 2 GE6 Panea et al 5,mottokIntegrativeGenomicAnalysis2019b? PASS
KANK2 Tier 2 GE7 Schmitz et al
KLHL26 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
KMT2C Tier 2 GE31 Zhou et al 3,32,sarkozyMutationalLandscapeGray2021a?
MCL1 Tier 2 GE6 Panea et al 11,dunsCharacterizationDLBCLPMBL2021b? PASS
MIR142 Tier 2 GE4 Grande et al kwanhianMicroRNA142Mutated202012b?
MKI67 Tier 2 GE7 Schmitz et al russler-germainMutationsAssociatedProgression2023b?
MYO18A Tier 2 GE7 Schmitz et al
NBEAL1 Tier 2 GE1 Love et al PASS
NCOR2 Tier 2 GE7 Schmitz et al sarkozyMutationalLandscapeGray2021a?,spinaGeneticsNodalMarginal2016b?
NOA1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
P2RY2 Tier 2 GE1 Love et al PASS
PCBP1 Tier 2 GE7 Schmitz et al
PDCD11 Tier 2 GE7 Schmitz et al
PIM1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al dunsCharacterizationDLBCLPMBL2021b?,pasqualucciHypermutationMultipleProtooncogenes2001a?
PLCG2 Tier 2 GE6 Panea et al fanComprehensiveCharacterizationDriver2020b? PASS
PPP6R2 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
PREX1 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
RANBP6 Tier 2 GE1 Love et al PASS
REV3L Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
RNF144B Tier 2 GE6 Panea et al PASS
RPL10 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
S1PR2 Tier 2 GEmuppidiLossSignalingGa132014b? Muppidi et al 5
SAL3 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
TET2 Tier 2 GE22 Thomas et al albuquerqueEnhancingKnowledgeDiscovery2017a?
TOP2A Tier 2 GE7 Schmitz et al
TTN Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
VWA7 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
WDR90 Tier 2 GE7 Schmitz et al
WHAMM Tier 2 GE7 Schmitz et al
WNK2 Tier 2 GE6 Panea et al PASS
YY1AP1 Tier 2 GE7 Schmitz et al
ZAN Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al
ZBTB7A Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al 11
ZFP36L1 Tier 2 GE6 Panea et al 5,reichelFlowSortingExome2015a? PASS
ZNF85 Tier 2 GEburkhardtClinicalRelevanceMolecular2022b? Burkhardt et al

Tier 3 BL genes

70 total

Gene Summary First BL study Other entities QC result
ACAD9 Tier 3 GE1 Love et al FAIL
ACE Tier 3 GE1 Love et al 3 FAIL
ALPK2 Tier 3 GE6 Panea et al FAIL
ATP2C2 Tier 3 GE1 Love et al FAIL
BRAF Tier 3 GE1 Love et al tiacciBRAFMutationsHairycell2011a? FAIL
BRD4 Tier 3 GE1 Love et al 3 FAIL
BTG2 Tier 3 GE1, CE33 Love et al 5 FAIL
C6orf27 Tier 3 GE1 Love et al FAIL
CAD Tier 3 GE1 Love et al 3 FAIL
CCT6B Tier 3 GE1 Love et al FAIL
CD79B Tier 3 GE6, FE34 Panea et al 5 FAIL
CDH17 Tier 3 GE1 Love et al FAIL
COL4A2 Tier 3 GE1 Love et al FAIL
CTCF Tier 3 GE6 Panea et al FAIL
CYB5D1 Tier 3 GE1 Love et al FAIL
CYP4F22 Tier 3 GE1 Love et al FAIL
DLGAP1 Tier 3 GE1 Love et al 3 FAIL
DNMT1 Tier 3 GE6 Panea et al FAIL
DTX1 Tier 3 GE1, FE35, CEmerirantaDeltex1MutationsPredict2017b? Love et al 3,36,rossiCodingGenomeSplenic2012c? FAIL
EIF2C4 Tier 3 GE1 Love et al FAIL
EML2 Tier 3 GE1 Love et al FAIL
ENTPD3 Tier 3 GE1 Love et al FAIL
EPHB2 Tier 3 GE1 Love et al FAIL
ETS1 Tier 3 GE6 Panea et al 5 FAIL
FAM129B Tier 3 GE1 Love et al FAIL
FGFR3 Tier 3 GE1 Love et al FAIL
FTCD Tier 3 GE1 Love et al FAIL
FZD3 Tier 3 GE6 Panea et al FAIL
GRIK5 Tier 3 GE1 Love et al FAIL
HIST1H1C Tier 3 GE6 Panea et al 5 FAIL
HIST1H2AG Tier 3 GE6 Panea et al 15,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c? FAIL
HIST1H2AM Tier 3 GE6 Panea et al chapuyMolecularSubtypesDiffuse2018b?,krysiakRecurrentSomaticMutations2017b? FAIL
HIST1H2BK Tier 3 GE6 Panea et al 3,rossiCodingGenomeSplenic2012c? FAIL
HIST1H3H Tier 3 GE6 Panea et al FAIL
HIST1H3J Tier 3 GE6 Panea et al FAIL
ICK Tier 3 GE1 Love et al FAIL
ITPR3 Tier 3 GE1 Love et al tiacciPervasiveMutationsJAKSTAT2018b? FAIL
KCNK10 Tier 3 GE6 Panea et al FAIL
KIFC3 Tier 3 GE1 Love et al FAIL
MAP3K6 Tier 3 GE1 Love et al FAIL
MME Tier 3 GE6 Panea et al FAIL
MTOR Tier 3 GE6 Panea et al 3 FAIL
MYH10 Tier 3 GE1 Love et al FAIL
NOTCH1 Tier 3 GE1, CE37 Love et al 18,38,rossiCodingGenomeSplenic2012c? FAIL
NRXN2 Tier 3 GE1 Love et al 3 FAIL
PABPC4L Tier 3 GE6 Panea et al FAIL
PC Tier 3 GE1 Love et al FAIL
PCDHA11 Tier 3 GE6 Panea et al FAIL
PDZRN3 Tier 3 GE6 Panea et al 3 FAIL
PIK3R1 Tier 3 GE6 Panea et al 3 FAIL
POLRMT Tier 3 GE1 Love et al FAIL
POR Tier 3 GE1 Love et al FAIL
PRSS22 Tier 3 GE1 Love et al FAIL
PTPRN Tier 3 GE1 Love et al FAIL
PXDNL Tier 3 GE6 Panea et al FAIL
RBP3 Tier 3 GE1 Love et al FAIL
RET Tier 3 GE1 Love et al fanComprehensiveCharacterizationDriver2020b? FAIL
SALL3 Tier 3 GE1 Love et al 32 FAIL
SAPS2 Tier 3 GE1 Love et al FAIL
SBF1 Tier 3 GE1 Love et al FAIL
SF3B1 Tier 3 GE1 Love et al 11 FAIL
SHANK1 Tier 3 GE1 Love et al FAIL
SLC29A2 Tier 3 GE1 Love et al FAIL
SNTB2 Tier 3 GE6 Panea et al FAIL
SYNGAP1 Tier 3 GE1 Love et al FAIL
TBC1D9B Tier 3 GE1 Love et al FAIL
TIGD6 Tier 3 GE1 Love et al FAIL
TPST2 Tier 3 GE1 Love et al FAIL
WDR7 Tier 3 GE6 Panea et al FAIL
ZNF229 Tier 3 GE1 Love et al FAIL

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