Origins of BL genes

Tier 1 BL genes

29 total

Gene Tier First BL evidence Other entities
ARID1A 1 Study Page1 2,wienandGenomicAnalysesFlowsorted2019b?,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c?
BCL7A 1, aSHM Study Page3 4,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
BMP7 1 Study Page5
CCND3 1 Study PagerichterRecurrentMutationID32012a? 68
CHD8 1 Study Page3 9
DDX3X 1 Study Page10 schmitzGeneticsPathogenesisDiffuse2018a?,mottokIntegrativeGenomicAnalysis2019b?
EIF4A1 1 Study Page5
EPPK1 1 Study Page5
FBXO11 1 Study PagerichterRecurrentMutationID32012a? 11,hubschmannMutationalMechanismsShaping2021b?
FOXO1 1 Study Page10 7,dunsCharacterizationDLBCLPMBL2021b?
GNA13 1 Study Page1 7,reichelFlowSortingExome2015a?
GNAI2 1 Study Page3 12
HNRNPU 1, aSHM Study Page5 9
ID3 1 Study PagerichterRecurrentMutationID32012a? 10,spinaGeneticsNodalMarginal2016b?
KMT2D 1 Study Page3 6,7,13,rossiCodingGenomeSplenic2012c?
MYC 1, aSHM Study Page14 8,pasqualucciHypermutationMultipleProtooncogenes2001a?,dunsCharacterizationDLBCLPMBL2021b?
P2RY8 1 Study PagemuppidiLossSignalingGa132014b? lohrDiscoveryPrioritizationSomatic2012a?
PHF6 1 Study Page15 9
PTEN 1 Study Page1
RFX7 1 Study Page3
RHOA 1 Study PagerichterRecurrentMutationID32012a?
SIN3A 1 Study Page3 rossiCodingGenomeSplenic2012c?
SMARCA4 1 Study PagerichterRecurrentMutationID32012a? lohrDiscoveryPrioritizationSomatic2012a?,krysiakRecurrentSomaticMutations2017b?,nadeuGenomicEpigenomicInsights2020b?
TCF3 1 Study Page10
TCL1A 1, aSHM Study Page3
TFAP4 1 Study Page3
TP53 1 Study Page16 7,13,lohrDiscoveryPrioritizationSomatic2012a?,tiacciPervasiveMutationsJAKSTAT2018b?,rossiCodingGenomeSplenic2012c?
USP7 1 Study Page3
WNK1 1 Study Page15 8,hubschmannMutationalMechanismsShaping2021b?

Tier 2 BL genes

155 total

Gene Tier First BL evidence Other entities
ACAD9 2 Study Page1
ACE 2 Study Page1
ADAMTS5 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
ADNP 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
AGO4 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
ALPK2 2 Study Page5
ARHGEF1 2 Study PagemuppidiLossSignalingGa132014b?
ATP2C2 2 Study Page1
BACH2 2, aSHM Study Page3
BCL2 2, aSHM Study PageburkhardtClinicalRelevanceMolecular2022b? 7,17,sarkozyMutationalLandscapeGray2021a?
BCL6 2, aSHM Study Page1 7
BRAF 2 Study Page1 tiacciBRAFMutationsHairycell2011a?
BRD4 2 Study Page1
BTG1 2, aSHM Study PageburkhardtClinicalRelevanceMolecular2022b? 7,sarkozyMutationalLandscapeGray2021a?
BTG2 2, aSHM Study Page1 7
C16orf48 2 Study Page10
C6orf27 2 Study Page1
CAD 2 Study Page1
CARD11 2 Study Page5 7,18,19,yanBCRTLRSignaling2012a?
CARD4 2 Study Page1
CCNF 2 Study PageabateDistinctViralMutational2015a?
CCT6B 2 Study Page1
CD79A 2 Study PageburkhardtClinicalRelevanceMolecular2022b? rossiCodingGenomeSplenic2012c?
CD79B 2 Study Page5 7
CD83 2, aSHM Study Page5 12,dunsCharacterizationDLBCLPMBL2021b?,russler-germainMutationsAssociatedProgression2023b?
CDC73 2 Study Page1 9
CDH17 2 Study Page1
CDKN2A 2 Study Page3 12,spinaGeneticsNodalMarginal2016b?
CDKN2C 2 Study Page15
CHD4 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
COL4A2 2 Study Page1
CPXM2 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
CREBBP 2 Study Page1 11,dunsCharacterizationDLBCLPMBL2021b?,pasqualucciInactivatingMutationsAcetyltransferase2011a?
CTCF 2 Study Page5
CXCR4 2, aSHM Study Page5 20,krysiakRecurrentSomaticMutations2017b?
CYB5D1 2 Study Page1
CYP4F22 2 Study Page1
DHCR7 2 Study Page10
DLGAP1 2 Study Page1
DNMT1 2 Study Page5
DTX1 2, aSHM Study Page1 21,rossiCodingGenomeSplenic2012c?,schmitzGeneticsPathogenesisDiffuse2018a?
E2F2 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
EBF1 2, aSHM Study Page15 22,reichelFlowSortingExome2015a?
EDNRB 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
EHD1 2 Study Page15
EIF2C4 2 Study Page1
ELP2 2 Study Page10
EML2 2 Study Page1
ENTPD3 2 Study Page1
EP300 2 Study Page5 rossiCodingGenomeSplenic2012c?,pasqualucciInactivatingMutationsAcetyltransferase2011a?
EPHB2 2 Study Page1
ERAP1 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
ETS1 2, aSHM Study Page5 7
EXOSC6 2 Study Page10
EZH2 2 Study Page1 mottokIntegrativeGenomicAnalysis2019b?,morinSomaticMutationsAltering2010a?
FAM129B 2 Study Page1
FGFR3 2 Study Page1
FLYWCH1 2 Study Page10
FTCD 2 Study Page1
FZD3 2 Study Page5
GGTLA4 2 Study Page1
GRB2 2 Study Page5 23
GRIK5 2 Study Page1
GTSE1 2 Study Page10
HIST1H1C 2, aSHM Study Page5 7
HIST1H1E 2, aSHM Study Page3 lohrDiscoveryPrioritizationSomatic2012a?,reichelFlowSortingExome2015a?,krysiakRecurrentSomaticMutations2017b?
HIST1H2AG 2, aSHM Study Page5 12,rossiCodingGenomeSplenic2012c?,krysiakRecurrentSomaticMutations2017b?
HIST1H2AM 2, aSHM Study Page5 krysiakRecurrentSomaticMutations2017b?
HIST1H2BK 2, aSHM Study Page5 rossiCodingGenomeSplenic2012c?
HIST1H3D 2, aSHM Study Page5
HIST1H3H 2, aSHM Study Page5
HIST1H3I 2, aSHM Study Page5 krysiakRecurrentSomaticMutations2017b?
HIST1H3J 2, aSHM Study Page5
HIST1H4J 2, aSHM Study Page5 mottokIntegrativeGenomicAnalysis2019b?
HLA-A 2 6,lohrDiscoveryPrioritizationSomatic2012a?
HLA-B 2 wienandGenomicAnalysesFlowsorted2019b?,lohrDiscoveryPrioritizationSomatic2012a?
HLA-DMB 2
HLA-DQB1 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
ICK 2 Study Page1
IGLL5 2, aSHM Study Page5 6,russler-germainMutationsAssociatedProgression2023b?
IKZF3 2, aSHM Study Page5 12
IRF8 2, aSHM Study Page5 7,mottokIntegrativeGenomicAnalysis2019b?
ITPR3 2 Study Page1 tiacciPervasiveMutationsJAKSTAT2018b?
KANK2 2 Study Page10
KCNK10 2 Study Page5
KIFC3 2 Study Page1
KLHL26 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
KLHL6 2, aSHM Study Page5 7,24
KMT2C 2 Study Page25 2,26,sarkozyMutationalLandscapeGray2021a?
LTB 2, aSHM Study Page5 6,chapuyMolecularSubtypesDiffuse2018b?
MAP3K6 2 Study Page1
MCL1 2 Study Page5 9,dunsCharacterizationDLBCLPMBL2021b?
MIR142 2, aSHM Study Page3 kwanhianMicroRNA142Mutated202012b?
MKI67 2 Study Page10 russler-germainMutationsAssociatedProgression2023b?
MME 2 Study Page5
MTOR 2 Study Page5 2
MYH10 2 Study Page1
MYO18A 2 Study Page10
NBEAL1 2 Study Page1
NCOR2 2 Study Page10 sarkozyMutationalLandscapeGray2021a?,spinaGeneticsNodalMarginal2016b?
NOA1 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
NOTCH1 2 Study Page1 13,23,rossiCodingGenomeSplenic2012c?
NOTCH2 2 Study Page5 13,27,rossiCodingGenomeSplenic2012c?
NRXN2 2 Study Page1
P2RY2 2 Study Page1
PABPC4L 2 Study Page5
PC 2 Study Page1
PCBP1 2 Study Page10
PCDHA11 2 Study Page5
PDCD11 2 Study Page10
PDZRN3 2 Study Page5
PIK3R1 2 Study Page5 2
PIM1 2, aSHM Study PageburkhardtClinicalRelevanceMolecular2022b? pasqualucciHypermutationMultipleProtooncogenes2001a?,dunsCharacterizationDLBCLPMBL2021b?
PLCG2 2 Study Page5
POLRMT 2 Study Page1
POR 2 Study Page1
PPP6R2 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
PREX1 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
PRSS22 2 Study Page1
PTPRN 2 Study Page1
PXDNL 2 Study Page5
RAC2 2 Study Page5 hubschmannMutationalMechanismsShaping2021b?
RANBP6 2 Study Page1
RBP3 2 Study Page1
RET 2 Study Page1
REV3L 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
RNF144B 2 Study Page5
RPL10 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
S1PR2 2, aSHM Study PagemuppidiLossSignalingGa132014b? 7
SAL3 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
SALL3 2 Study Page1 26
SAPS2 2 Study Page1
SBF1 2 Study Page1
SF3B1 2 Study Page1
SHANK1 2 Study Page1
SLC29A2 2 Study Page1
SNTB2 2 Study Page5
SYNGAP1 2 Study Page1
TBC1D9B 2 Study Page1
TET2 2 Study Page5 albuquerqueEnhancingKnowledgeDiscovery2017a?
TIGD6 2 Study Page1
TOP2A 2 Study Page10
TPST2 2 Study Page1
TTN 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
VWA7 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
WDR7 2 Study Page5
WDR90 2 Study Page10
WHAMM 2 Study Page10
WNK2 2 Study Page5
YY1AP1 2 Study Page10
ZAN 2 Study PageburkhardtClinicalRelevanceMolecular2022b?
ZBTB7A 2 Study PageburkhardtClinicalRelevanceMolecular2022b? 9
ZFP36L1 2, aSHM Study Page5 7,reichelFlowSortingExome2015a?
ZNF229 2 Study Page1
ZNF85 2 Study PageburkhardtClinicalRelevanceMolecular2022b?

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Ganapathi KA, Jobanputra V, Iwamoto F, Jain P, Chen J, Cascione L, Nahum O, Levy B, Xie Y, Khattar P, Hoehn D, Bertoni F, Murty VV, Pittaluga S, Jaffe ES, Alobeid B, Mansukhani MM, Bhagat G. The genetic landscape of dural marginal zone lymphomas. Oncotarget. Impact Journals; 2016 May 27;7(28):43052–43061.
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Zhou P, Blain AE, Newman AM, Zaka M, Chagaluka G, Adlar FR, Offor UT, Broadbent C, Chaytor L, Whitehead A, Hall A, O’Connor H, Van Noorden S, Lampert I, Bailey S, Molyneux E, Bacon CM, Bomken S, Rand V. Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif. Blood Adv. 2019 Jul 23;3(14):2118–2127. PMCID: PMC6650741
26.
Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.
27.
Trøen G, Wlodarska I, Warsame A, Hernández Llodrà S, De Wolf-Peeters C, Delabie J. NOTCH2 mutations in marginal zone lymphoma. Haematologica. 2008 Jul;93(7):1107–1109.