CARD11

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2008-03-03 : Lenz : DLBCL 2011-07-27 : Morin : FL 2012-04-01 : Yan : MZL 2016-06-21 : Wu : MCL

Relevance tier by entity

Entity Tier Description
MZL 1 high-confidence MZL geneyanBCRTLRSignaling2012a?
DLBCL 1 high-confidence DLBCL gene1
FL 1 high-confidence FL gene2
MCL 1 high-confidence MCL gene3

|BL|2|relevance in BL not firmly established| ## Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 4.16
BL Thomas cohort 1.70
BL Panea cohort 10.90
DLBCL GAMBL genomes 11.28
DLBCL Schmitz cohort 15.32
DLBCL Reddy cohort 7.81
DLBCL Chapuy cohort 8.12
FL GAMBL genomes 14.78
MCL GAMBL genomes 1.42

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 5.307 0.000
DLBCL No Yes 16.898 0.000
FL No Yes 28.329 27.096

CARD11 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr7 2979522 T>C E242G
chr7 2979521 T>A E242D
chr7 2979513 A>G L245P
chr7 2979508 T>C R247G
chr7 2979501 T>G Q249P
chr7 2979499 A>G S250P
chr7 2979495 A>G L251P
chr7 2979493 T>A K252*
chr7 2979486 T>C K254R
chr7 2979481 C>T D256N
chr7 2977614 T>C D357G
chr7 2977614 T>A D357V
chr7 2977604 C>A M360I
chr7 2977602 T>G Y361S
chr7 2977602 T>C Y361C

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

CARD11 Expression

References

1.
Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008 Mar;319(5870):1676–1679.
2.
Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554
3.
Wu C, de Miranda NF, Chen L, Wasik AM, Mansouri L, Jurczak W, Galazka K, Dlugosz-Danecka M, Machaczka M, Zhang H, Peng R, Morin RD, Rosenquist R, Sander B, Pan-Hammarström Q. Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget. 2016 Jun 21;7(25):38180–38190. PMCID: PMC5122381

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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