CD36
CD36 is a transmembrane glycoprotein involved in fatty acid metabolism, glucose intolerance, and immune responses. It is expressed on various cell types, including platelets, monocytes, and some lymphocytes. One study showed higher rates of CD36 mutations in FL relative to DLBCLs.1 ## History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence DLBCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.29 |
| DLBCL | Schmitz cohort | 4.89 |
| DLBCL | Reddy cohort | 2.80 |
| DLBCL | Chapuy cohort | 2.99 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 4.616 | 0.000 |
| DLBCL | No | No | 0.822 | 7.247 |
| FL | No | No | 1.559 | 0.000 |
[!NOTE] First described in DLBCL in 2011 by Pasqualucci L
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
References
-
Carreras J, Ikoma H, Kikuti YY, Miyaoka M, Hiraiwa S, Tomita S,
Kondo Y, Ito A, Nagase S, Miura H, Kawada H, Roncador G, Campo E,
Hamoudi R, Nakamura N. Mutational, immune microenvironment, and
clinicopathological profiles of diffuse large B-cell lymphoma and
follicular lymphoma with BCL6 rearrangement. Virchows Arch. 2024
Apr;484(4):657-676. doi: 10.1007/s00428-024-03774-z. Epub 2024 Mar 11.
PMID: 38462571. ## CD36 Expression
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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