CHST2
The variants reported in this gene in DLBCL failed QC
History
Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.1 Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.
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timeline
title Publication timing
2017-10-10 : Reddy : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2-F | failed QC |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.34 |
| DLBCL | Schmitz cohort | 2.34 |
| DLBCL | Reddy cohort | 0.70 |
| DLBCL | Chapuy cohort | 0.43 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.786 | 0 |
| DLBCL | No | No | 0.000 | 0 |
| FL | No | No | 0.000 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
CHST2 Expression
All Mutations
Reddy_2073T Reddy_2091T Reddy_2163T Reddy_2204T Reddy_2217T Reddy_2302T Reddy_2459T Reddy_2561T Reddy_2652T Reddy_2687T Reddy_2781T Reddy_2901T Reddy_2912T Reddy_2918T Reddy_2933T Reddy_2953T Reddy_3394T Reddy_3404T Reddy_3467T Reddy_3496T Reddy_3511T Reddy_3632T Reddy_3656T Reddy_3660T Reddy_3672T Reddy_3712T Reddy_3734T Reddy_3736T Reddy_3760T Reddy_3815T Reddy_3834T Reddy_3917T Reddy_3998T