[CIITA]
Mutation tier
| Entity | Tier |
|---|---|
| DLBCL | 1 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.5 |
| DLBCL | Schmitz cohort | 6.6 |
| DLBCL | Reddy cohort | 4.3 |
| DLBCL | Chapuy cohort | 4.3 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 1.029 | 0.000 |
| DLBCL | Yes | No | 0.648 | 4.031 |
| FL | Yes | No | 2.701 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr16 | 10970795 | 10975465 | TSS | active_promoter-strong_enhancer |
[!NOTE] First described in DLBCL in 2011 by Morin RD
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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