CPNE8

History

Mutations in this gene were first described in FL in 2021 by Hübschmann et al.¹

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Relevance tier by entity

Entity	Tier	Description
	2	relevance in FL not firmly established^{hubschmannMutationalMechanismsShaping2021b?}

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
FL	GAMBL genomes	2.08

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.932	0.000
DLBCL	No	No	2.398	0.000
FL	No	No	1.808	12.601

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

CPNE8 Expression

All Mutations

SP192870 SP116694 SP193954 SP193150 SP116720

References

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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