Table of Contents

Experimental Evidence

Driver mutations affecting this gene in FL have been experimentally demonstrated to cause a gain of function (GOF).dheillyCathepsinRegulatesAntigen2020?

Relevance tier by entity

Cannot include /table1_CTSS.md - does not exist yet

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 11 0.0101 [0.0042,0.016]
DLBCL GAMBL with Reddy 2,088 22 0.0105 [0.0062,0.0149]
DLBCL BC 231 3 0.0130 [0,0.0276]
DLBCL Dana-Farber 303 0 0.0003 [0,0.0024]
DLBCL NCI 470 7 0.0149 [0.0039,0.0258]
DLBCL Reddy 999 11 0.0110 [0.0045,0.0175]
DLBCL DLBCL_ICGC 85 1 0.0118 [0,0.0347]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 21 0.0327 [0.019,0.0465]
FL GAMBL with Crouch 1,189 21 0.0177 [0.0102,0.0251]
FL BC 379 16 0.0422 [0.022,0.0625]
FL Kalmbach 164 2 0.0122 [0,0.029]
FL Crouch 547 0 0.0002 [0,0.0013]
FL FL_ICGC 99 3 0.0303 [0,0.0641]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 0.0000 0.0000 1.0000
FL 23.2540 8.4219 0.0000
DLBCL 0.9995 1.8618 0.9986

CTSS Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr1 150727482 A>C Y132D
chr1 150727482 A>T Y132N

Cannot include /browser_CTSS.md - does not exist yet

Expression

Cannot include /mermaid_CTSS.md - does not exist yet

References

1.
Bararia D, Hildebrand JA, Stolz S, Haebe S, Alig S, Trevisani CP, Osorio-Barrios F, Bartoschek MD, Mentz M, Pastore A, Gaitzsch E, Heide M, Jurinovic V, Rautter K, Gunawardana J, Sabdia MB, Szczepanowski M, Richter J, Klapper W, Louissaint A, Ludwig C, Bultmann S, Leonhardt H, Eustermann S, Hopfner KP, Hiddemann W, von Bergwelt-Baildon M, Steidl C, Kridel R, Tobin JWD, Gandhi MK, Weinstock DM, Schmidt-Supprian M, Sárosi MB, Rudelius M, Passerini V, Mautner J, Weigert O. Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Rep. 2020 May 5;31(5):107522.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.