[CXCR4]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 2 |
| DLBCL | 1 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 2.08 |
| BL | Thomas cohort | 2.10 |
| BL | Panea cohort | 2.00 |
| DLBCL | GAMBL genomes | 2.70 |
| DLBCL | Schmitz cohort | 2.60 |
| DLBCL | Reddy cohort | 1.50 |
| DLBCL | Chapuy cohort | 2.60 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 4.603 | 0.000 |
| DLBCL | Yes | No | 3.731 | 18.727 |
| FL | Yes | No | 0.000 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr2 | 136874728 | 136875461 | intron | weak_promoter |
[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2012 by Khodabakhshi AH
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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