[DDX3X]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 1 |
| DLBCL | 1 |
| FL | 2 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 44.34 |
| BL | Thomas cohort | 48.70 |
| BL | Panea cohort | 39.60 |
| DLBCL | GAMBL genomes | 8.60 |
| DLBCL | Schmitz cohort | 4.70 |
| DLBCL | Reddy cohort | 4.50 |
| DLBCL | Chapuy cohort | 5.60 |
| FL | GAMBL genomes | 2.54 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | Yes | 19.270 | 125.826 |
| DLBCL | Yes | No | 3.193 | 8.744 |
| FL | Yes | No | 11.136 | 21.489 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chrX | 42800580 | 42804184 | intergenic | NA |
[!NOTE] First described in BL in 2012 by Schmitz R. First described in DLBCL in 2018 by Schmitz R. First described in FL in 2023 by Dreval K
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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