DLBCL genes

Origins of DLBCL genessankey

Tier 1 DLBCL genes

128 total

Gene Tier Relevant references
ACTB 1, aSHM Lohr et al. 2012
ACTG1 1, aSHM Hübschmann et al. 2021
ARID1A 1 Zhang et al. 2013; Krysiak et al. 2017; Love et al. 2012
ATM 1 Reddy et al. 2017; Beà et al. 2013
B2M 1 Morin et al. 2011; Pararajalingam et al. 2020
BCL10 1 Morin et al. 2011; Russler-Germain et al. 2023
BCL2 1, aSHM Burkhardt et al. 2022; Morin et al. 2011; Tanaka et al. 1992
BCL6 1, aSHM Love et al. 2012; Morin et al. 2011
BCL7A 1, aSHM Grande et al. 2019; Krysiak et al. 2017; Arthur et al. 2018
BIRC6 1 Reddy et al. 2017
BRAF 1 Tiacci et al. 2011; Love et al. 2012
BTG1 1, aSHM Burkhardt et al. 2022; Morin et al. 2011
BTG2 1, aSHM Love et al. 2012; Morin et al. 2011
BTK 1 Krysiak et al. 2017; Albuquerque et al. 2017
CARD11 1 Morin et al. 2011; Lenz et al. 2008; Panea et al. 2019; Wu et al. 2016
CCND3 1 Richter et al. 2012; Morin et al. 2011
CD58 1 Morin et al. 2011
CD70 1 Russler-Germain et al. 2023; Morin et al. 2011
CD79B 1 Morin et al. 2011; Panea et al. 2019
CD83 1, aSHM Panea et al. 2019; Morin et al. 2013; Russler-Germain et al. 2023
CDKN2A 1 Morin et al. 2013; Grande et al. 2019
CIITA 1, aSHM Morin et al. 2011
CREBBP 1 Laura Pasqualucci, Dominguez-Sola, et al. 2011; Love et al. 2012
CXCR4 1, aSHM Khodabakhshi et al. 2012; Krysiak et al. 2017; Panea et al. 2019
CXCR5 1 Schmitz et al. 2018
DDX3X 1 Schmitz et al. 2018, 2012
DTX1 1, aSHM Panea et al. 2019; Schmitz et al. 2018
DUSP2 1, aSHM Morin et al. 2013
EBF1 1, aSHM Thomas et al. 2023; Bohle et al. 2013
EEF1A1 1 Hübschmann et al. 2021
EP300 1 Laura Pasqualucci, Dominguez-Sola, et al. 2011; Panea et al. 2019
ETS1 1, aSHM Morin et al. 2011; Panea et al. 2019
ETV6 1, aSHM Arthur et al. 2018
EZH2 1 Morin et al. 2010; Love et al. 2012
FAS 1 Scholl et al. 2007
FBXO11 1 Richter et al. 2012; Hübschmann et al. 2021
FBXW7 1 Zhang et al. 2013
FOXO1 1 Morin et al. 2011; Schmitz et al. 2012
GNA13 1 Love et al. 2012; Morin et al. 2011
GNAI2 1 Morin et al. 2013; Grande et al. 2019
GRB2 1 Panea et al. 2019; Laura Pasqualucci, Trifonov, et al. 2011
GRHPR 1, aSHM Arthur et al. 2018
HIST1H1B 1, aSHM Chapuy et al. 2018; Krysiak et al. 2017
HIST1H1C 1, aSHM Panea et al. 2019; Morin et al. 2011
HIST1H1D 1, aSHM Krysiak et al. 2017; Morin et al. 2013
HIST1H1E 1, aSHM Krysiak et al. 2017; Grande et al. 2019; Morin et al. 2013
HIST1H2AC 1, aSHM Morin et al. 2013; Krysiak et al. 2017
HIST1H2AM 1, aSHM Panea et al. 2019; Krysiak et al. 2017
HIST1H2BC 1, aSHM Reddy et al. 2017; Krysiak et al. 2017
HIST1H2BK 1, aSHM Panea et al. 2019
HIST1H3B 1, aSHM Zhang et al. 2013
HIST2H2BE 1, aSHM Schmitz et al. 2018
HLA-A 1
HLA-B 1
HLA-C 1
HLA-DMB 1
HNRNPU 1, aSHM Reddy et al. 2017; Panea et al. 2019
HVCN1 1 Krysiak et al. 2017
IKZF3 1 Morin et al. 2013; Panea et al. 2019
IL4R 1, aSHM Duns et al. 2021
IRF4 1, aSHM Morin et al. 2011
IRF8 1, aSHM Morin et al. 2011; Panea et al. 2019
ITPKB 1, aSHM Schmitz et al. 2018
KLF2 1, aSHM Laura Pasqualucci, Trifonov, et al. 2011
KLHL14 1 Zhang et al. 2013
KLHL6 1, aSHM Morin et al. 2011; Panea et al. 2019
KMT2C 1 Zhang et al. 2014; Zhou et al. 2019; Zhang et al. 2013
KMT2D 1 Beà et al. 2013; Grande et al. 2019; Morin et al. 2011
KRAS 1 Lohr et al. 2012
LCOR 1 Arthur et al. 2018
LTB 1, aSHM Chapuy et al. 2018; Panea et al. 2019
MEF2B 1, aSHM Beà et al. 2013; Morin et al. 2011
MEF2C 1, aSHM Arthur et al. 2018
MGA 1 Zhang et al. 2013
MPEG1 1 Morin et al. 2013
MS4A1 1, aSHM Rushton et al. 2020
MTOR 1 Zhang et al. 2013; Panea et al. 2019
MYC 1, aSHM Johnston and Carroll 1992; L. Pasqualucci et al. 2001
MYD88 1 Ngo et al. 2011
NFKBIA 1 Lake et al. 2009; Russler-Germain et al. 2023
NFKBIE 1 Morin et al. 2016; Pararajalingam et al. 2020
NFKBIZ 1, noncoding Morin et al. 2016
NOL9 1, aSHM Schmitz et al. 2018
NOTCH1 1 Love et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011; Beà et al. 2013
NOTCH2 1 Trøen et al. 2008; Panea et al. 2019; Beà et al. 2013
OSBPL10 1, aSHM Arthur et al. 2018
P2RY8 1 Lohr et al. 2012; Muppidi et al. 2014
PIM1 1, aSHM Burkhardt et al. 2022; L. Pasqualucci et al. 2001
PIM2 1, aSHM Arthur et al. 2018
POU2AF1 1, aSHM Krysiak et al. 2017
POU2F2 1 Krysiak et al. 2017; Zhang et al. 2013
PRDM1 1 Laura Pasqualucci et al. 2006
PTEN 1 Love et al. 2012
PTPRD 1
RB1 1 Morin et al. 2013; Zhang et al. 2014
RFX7 1 Grande et al. 2019
RHOA 1 Richter et al. 2012
RRAGC 1 Okosun et al. 2016
S1PR2 1, aSHM Morin et al. 2011; Muppidi et al. 2014
SETD1B 1 Reddy et al. 2017
SF3B1 1 Love et al. 2012
SGK1 1, aSHM Morin et al. 2011
SIN3A 1 Grande et al. 2019
SMARCA4 1 Nadeu et al. 2020; Richter et al. 2012; Zhang et al. 2013; Krysiak et al. 2017
SOCS1 1, aSHM Morin et al. 2011
SPEN 1 Rossi et al. 2012
STAT3 1 Ohgami et al. 2014
STAT6 1 Yildiz et al. 2015
TAF1 1 Morin et al. 2013
TBL1XR1 1 Mareschal et al. 2016
TET2 1 Albuquerque et al. 2017; Panea et al. 2019
TMEM30A 1 Morin et al. 2011
TMSB4X 1, aSHM Albuquerque et al. 2017
TNFAIP3 1 Compagno et al. 2009
TNFRSF14 1 Cheung et al. 2010
TOX 1 Reddy et al. 2017
TP53 1 Morin et al. 2011; Wilda et al. 2004; Beà et al. 2013
TRRAP 1 Parry et al. 2013
UBE2A 1 Reddy et al. 2017
UNC5C 1
USP7 1 Grande et al. 2019
VPS13B 1
WEE1 1 Schmitz et al. 2018
XPO1 1 Mareschal et al. 2016
ZC3H12A 1 Arthur et al. 2018
ZFP36L1 1, aSHM Morin et al. 2011; Panea et al. 2019
ZNF292 1 Zhang et al. 2013
ZNF608 1, aSHM Krysiak et al. 2017; Zhang et al. 2013

Tier 2 DLBCL genes

198 total

Gene Tier Relevant references
ABI3BP 2 Morin et al. 2013
ADAMTS1 2 Hübschmann et al. 2021
AICDA 2, aSHM Arthur et al. 2018
ANKRD12 2 Hübschmann et al. 2021
ANKRD17 2 Reddy et al. 2017
ARID1B 2 Reddy et al. 2017
ARID5B 2 Reddy et al. 2017
ATR 2 Reddy et al. 2017
BCL11A 2, aSHM
BCOR 2 Nadeu et al. 2020
BCR 2, aSHM
BIRC3 2, aSHM Arthur et al. 2018; Beà et al. 2013
BLK 2, aSHM
BRINP3 2 Reddy et al. 2017
BTBD3 2 Reddy et al. 2017
CADPS2 2 Hübschmann et al. 2021
CASP8 2 Reddy et al. 2017
CBLB 2 Reddy et al. 2017
CCL4 2 Chapuy et al. 2018
CD22 2 Reddy et al. 2017
CD274 2 Morin et al. 2011
CD36 2 Laura Pasqualucci, Trifonov, et al. 2011
CD44 2, aSHM Arthur et al. 2018
CD74 2, aSHM Arthur et al. 2018
CDC73 2 Love et al. 2012; Reddy et al. 2017
CDH9 2 Morin et al. 2013
CHD1 2 Reddy et al. 2017
CHD8 2 Reddy et al. 2017; Grande et al. 2019
CHST2 2 Reddy et al. 2017
CNOT2 2 Hübschmann et al. 2021
CNTNAP5 2 Morin et al. 2013
COQ7 2 Chapuy et al. 2018
CRIP1 2 Chapuy et al. 2018
DAZAP1 2 Pararajalingam et al. 2020
DCAF6 2 Reddy et al. 2017
DDX10 2 Reddy et al. 2017
DHX16 2 Hübschmann et al. 2021
DICER1 2 Reddy et al. 2017
DNAH5 2 Morin et al. 2013
DNM2 2 Hübschmann et al. 2021
DNMT3A 2 Reddy et al. 2017
DOCK1 2 Chapuy et al. 2018
DSG4 2 Morin et al. 2013
EIF2AK3 2, aSHM
EZR 2, aSHM
FAM102A 2, aSHM
FAM38B 2 Morin et al. 2013
FANK1 2, aSHM
FAT4 2 Morin et al. 2013; Zhang et al. 2014
FCRL3 2, aSHM
FNBP1 2, aSHM
FNDC1 2 Morin et al. 2013
FOXC1 2 Schmitz et al. 2018
FOXP1 2, aSHM Reddy et al. 2017
FUBP1 2 Reddy et al. 2017
FUT5 2 Chapuy et al. 2018
GABRA2 2 Chapuy et al. 2018
GAK 2 Hübschmann et al. 2021
GNAS 2 Reddy et al. 2017
GOLGA5 2 Reddy et al. 2017
GPC5 2 Schmitz et al. 2018
GSG2 2 Schmitz et al. 2018
HDAC7 2 Morin et al. 2013
HIST1H2AG 2 Morin et al. 2013; Krysiak et al. 2017; Panea et al. 2019
HLA-DMA 2
HLA-DQA1 2 Hübschmann et al. 2021
HNF1B 2 Laura Pasqualucci, Trifonov, et al. 2011
HNRNPD 2
HNRNPH1 2, noncoding Pararajalingam et al. 2020
HRAS 2 Reddy et al. 2017
ID3 2 Schmitz et al. 2012; Richter et al. 2012
IER2 2 Morin et al. 2013
IFNGR1 2 Morin et al. 2013
IGLL5 2, aSHM Panea et al. 2019; Russler-Germain et al. 2023
IKBKB 2 Reddy et al. 2017
IKBKE 2 Hübschmann et al. 2021
IL16 2
IL6 2 Chapuy et al. 2018
INO80 2 Zhang et al. 2013
IRAG2 2, aSHM
IRF1 2, aSHM Hübschmann et al. 2021
JAK1 2 Zhang et al. 2013
JAK3 2 Zhang et al. 2013
JUNB 2 Reddy et al. 2017
KCMF1 2 Reddy et al. 2017
KLHL21 2 Schmitz et al. 2018
LAMA5 2 Schmitz et al. 2018
LAPTM5 2, aSHM Hübschmann et al. 2021
LIN54 2 Reddy et al. 2017
LPP 2, aSHM Arthur et al. 2018
LRP12 2 Hübschmann et al. 2021
LRRN3 2 Morin et al. 2013
LYN 2 Chapuy et al. 2018
MAGT1 2 Reddy et al. 2017
MALAT1 2, aSHM Arthur et al. 2018
MAP2K1 2 Louissaint et al. 2016; Shin et al. 2015
MAP4K4 2 Reddy et al. 2017
MARK1 2 Reddy et al. 2017
MCL1 2 Reddy et al. 2017; Panea et al. 2019
MECOM 2 Reddy et al. 2017
MET 2 Reddy et al. 2017
MIR142 2, aSHM Kwanhian et al. 2012; Grande et al. 2019
MIR155HG 2, aSHM
MPDZ 2 Morin et al. 2013
MSH2 2 Reddy et al. 2017
MSH6 2 Reddy et al. 2017
MYB 2 Reddy et al. 2017
MYBPC2 2 Schmitz et al. 2018
MYO1E 2, aSHM
MYOM2 2 Laura Pasqualucci, Trifonov, et al. 2011
N2RF2 2 Hübschmann et al. 2021
NANOG 2 Chapuy et al. 2018
NAV1 2 Chapuy et al. 2018
NCOA3 2, aSHM
NCOR1 2 Reddy et al. 2017
NCOR2 2 Schmitz et al. 2012
NEAT1 2, aSHM Arthur et al. 2018
NF1 2 Reddy et al. 2017
NFKB1 2
NFKB2 2 Reddy et al. 2017
NLRC5 2
NLRP5 2 Morin et al. 2013
NLRP8 2 Chapuy et al. 2018
ODZ3 2 Morin et al. 2013
P2RX5 2, aSHM Morin et al. 2013
PAPOLG 2 Schmitz et al. 2018
PASK 2 Morin et al. 2013
PAX5 2, aSHM L. Pasqualucci et al. 2001
PCBP1 2 Schmitz et al. 2012
PCDHB11 2 Morin et al. 2013
PCLO 2 Lohr et al. 2012
PDE4DIP 2 Chapuy et al. 2018
PDS5B 2 Hübschmann et al. 2021; Morin et al. 2013
PHF6 2 Thomas et al. 2023; Reddy et al. 2017
PIK3CD 2 Reddy et al. 2017
PIK3R1 2 Zhang et al. 2013; Panea et al. 2019
PKD1 2 Morin et al. 2013
PNPO 2 Hübschmann et al. 2021
POGZ 2 Morin et al. 2013
PPP1R9B 2
PRKCB 2 Morin et al. 2013
PRKDC 2 Hübschmann et al. 2021; Schmitz et al. 2018
PRPS1 2 Chapuy et al. 2018
PTMA 2, aSHM
PTPN1 2, aSHM
PTPN23 2 Morin et al. 2013
PTPN6 2 Reddy et al. 2017
PTPRK 2 Reddy et al. 2017
RAC2 2 Hübschmann et al. 2021; Panea et al. 2019
RAD9A 2 Chapuy et al. 2018
RARA 2 Reddy et al. 2017
RCC 2, aSHM
RFTN1 2, aSHM Arthur et al. 2018
RFXAP 2
RHEX 2, aSHM
RHOH 2, aSHM L. Pasqualucci et al. 2001
RUBCNL 2, aSHM
RUNX1 2 Reddy et al. 2017
SAMD9L 2 Morin et al. 2013
SARM1 2 Morin et al. 2013
SEL1L3 2, aSHM
SEPTIN9 2, aSHM
SERPINA9 2, aSHM Arthur et al. 2018
SETD2 2 Zhang et al. 2013
SETD5 2 Reddy et al. 2017
SIAH2 2 Hübschmann et al. 2021
SLC34A2 2 Hübschmann et al. 2021
SMEK1 2 Chapuy et al. 2018
SRRM2 2 Morin et al. 2013; Russler-Germain et al. 2023
ST6GAL1 2, aSHM Arthur et al. 2018
STAT5B 2 Zhang et al. 2013
SYK 2 Reddy et al. 2017
SYPL1 2 Morin et al. 2013
TAP1 2 Schmitz et al. 2018
TBC1D4 2, aSHM Arthur et al. 2018
TCL1A 2, aSHM Grande et al. 2019
TGFBR2 2 Reddy et al. 2017
TIPARP 2 Reddy et al. 2017
TLR2 2 Beà et al. 2013; Chapuy et al. 2018
TRAF3 2 Laura Pasqualucci, Trifonov, et al. 2011
TRAF6 2 Hübschmann et al. 2021
TRIP12 2
UBE2J1 2, aSHM
UBR5 2 Zhang et al. 2013; Pararajalingam et al. 2020
UNC5B 2 Hübschmann et al. 2021
UNC5D 2
WAC 2 Reddy et al. 2017
WDFY3 2 Morin et al. 2013
WNK1 2 Thomas et al. 2023; Hübschmann et al. 2021
XBP1 2, aSHM
YY1 2 Reddy et al. 2017
ZBTB7A 2 Reddy et al. 2017; Burkhardt et al. 2022
ZCCHC7 2, aSHM Arthur et al. 2018
ZEB2 2 Zhang et al. 2013
ZFAT 2 Reddy et al. 2017
ZFX 2 Reddy et al. 2017
ZNF217 2 Hübschmann et al. 2021
ZNF423 2 Chapuy et al. 2018

References

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