DLBCL genes

Origins of DLBCL genessankey

Tier 1 DLBCL genes

131 total

Gene Tier Relevant references
ACTB 1, aSHM Lohr et al. 2012
ACTG1 1, aSHM Hübschmann et al. 2021
ARID1A 1 Zhang et al. 2013; Krysiak et al. 2017; Love et al. 2012
ATM 1 Reddy et al. 2017; Beà et al. 2013
B2M 1 Morin et al. 2011; Pararajalingam et al. 2020
BCL10 1 Morin et al. 2011; Russler-Germain et al. 2023
BCL2 1, aSHM Burkhardt et al. 2022; Tanaka et al. 1992; Morin et al. 2011
BCL6 1, aSHM Morin et al. 2011; Love et al. 2012
BCL7A 1, aSHM Grande et al. 2019; Arthur et al. 2018; Krysiak et al. 2017
BIRC6 1 Reddy et al. 2017
BRAF 1 Tiacci et al. 2011; Love et al. 2012
BTG1 1, aSHM Morin et al. 2011; Burkhardt et al. 2022
BTG2 1, aSHM Morin et al. 2011; Love et al. 2012
BTK 1 Krysiak et al. 2017; Albuquerque et al. 2017
CARD11 1 Lenz et al. 2008; Morin et al. 2011; Wu et al. 2016; Panea et al. 2019
CASP8 1 Reddy et al. 2017
CCND3 1 Richter et al. 2012; Morin et al. 2011
CD58 1 Morin et al. 2011
CD70 1 Morin et al. 2011; Russler-Germain et al. 2023
CD79B 1 Morin et al. 2011; Panea et al. 2019
CD83 1, aSHM Russler-Germain et al. 2023; Panea et al. 2019; Morin et al. 2013
CDKN2A 1 Morin et al. 2013; Grande et al. 2019
CIITA 1, aSHM Morin et al. 2011
CREBBP 1 Love et al. 2012; Laura Pasqualucci, Dominguez-Sola, et al. 2011
CXCR4 1, aSHM Krysiak et al. 2017; Panea et al. 2019; Khodabakhshi et al. 2012
CXCR5 1 Schmitz et al. 2018
DDX3X 1 Schmitz et al. 2012, 2018
DTX1 1, aSHM Panea et al. 2019; Schmitz et al. 2018
DUSP2 1, aSHM Morin et al. 2013
EBF1 1, aSHM Bohle et al. 2013; Thomas et al. 2023
EEF1A1 1 Hübschmann et al. 2021
EP300 1 Laura Pasqualucci, Dominguez-Sola, et al. 2011; Panea et al. 2019
ETS1 1, aSHM Panea et al. 2019; Morin et al. 2011
ETV6 1, aSHM Arthur et al. 2018
EZH2 1 Love et al. 2012; Morin et al. 2010
FAS 1 Scholl et al. 2007
FBXO11 1 Hübschmann et al. 2021; Richter et al. 2012
FBXW7 1 Zhang et al. 2013
FOXO1 1 Schmitz et al. 2012; Morin et al. 2011
GNA13 1 Love et al. 2012; Morin et al. 2011
GNAI2 1 Grande et al. 2019; Morin et al. 2013
GRB2 1 Laura Pasqualucci, Trifonov, et al. 2011; Panea et al. 2019
GRHPR 1, aSHM Arthur et al. 2018
HIST1H1B 1, aSHM Chapuy et al. 2018; Krysiak et al. 2017
HIST1H1C 1, aSHM Morin et al. 2011; Panea et al. 2019
HIST1H1D 1, aSHM Morin et al. 2013; Krysiak et al. 2017
HIST1H1E 1, aSHM Krysiak et al. 2017; Morin et al. 2013; Grande et al. 2019
HIST1H2AC 1, aSHM Krysiak et al. 2017; Morin et al. 2013
HIST1H2AM 1, aSHM Krysiak et al. 2017; Panea et al. 2019
HIST1H2BC 1, aSHM Reddy et al. 2017; Krysiak et al. 2017
HIST1H2BK 1, aSHM Panea et al. 2019
HIST1H3B 1, aSHM Zhang et al. 2013
HIST2H2BE 1, aSHM Schmitz et al. 2018
HLA-A 1
HLA-B 1
HLA-C 1
HLA-DMB 1
HNRNPU 1, aSHM Panea et al. 2019; Reddy et al. 2017
HVCN1 1 Krysiak et al. 2017
IKZF3 1 Morin et al. 2013; Panea et al. 2019
IL4R 1, aSHM Duns et al. 2021
IRF4 1, aSHM Morin et al. 2011
IRF8 1, aSHM Morin et al. 2011; Panea et al. 2019
ITPKB 1, aSHM Schmitz et al. 2018
KLF2 1, aSHM Laura Pasqualucci, Trifonov, et al. 2011
KLHL14 1 Zhang et al. 2013
KLHL6 1, aSHM Morin et al. 2011; Panea et al. 2019
KMT2C 1 Zhang et al. 2014; Zhou et al. 2019; Zhang et al. 2013
KMT2D 1 Grande et al. 2019; Morin et al. 2011; Beà et al. 2013
KRAS 1 Lohr et al. 2012
LCOR 1 Arthur et al. 2018
LTB 1, aSHM Chapuy et al. 2018; Panea et al. 2019
MEF2B 1, aSHM Beà et al. 2013; Morin et al. 2011
MEF2C 1, aSHM Arthur et al. 2018
MGA 1 Zhang et al. 2013
MPEG1 1 Morin et al. 2013
MS4A1 1, aSHM Rushton et al. 2020
MTOR 1 Zhang et al. 2013; Panea et al. 2019
MYC 1, aSHM Johnston and Carroll 1992; L. Pasqualucci et al. 2001
MYD88 1 Ngo et al. 2011
MYOM2 1 Laura Pasqualucci, Trifonov, et al. 2011
NFKBIA 1 Russler-Germain et al. 2023; Lake et al. 2009
NFKBIE 1 Pararajalingam et al. 2020; Morin et al. 2016
NFKBIZ 1, noncoding Morin et al. 2016
NOL9 1 Schmitz et al. 2018
NOTCH1 1 Love et al. 2012; Beà et al. 2013; Laura Pasqualucci, Trifonov, et al. 2011
NOTCH2 1 Beà et al. 2013; Trøen et al. 2008; Panea et al. 2019
OSBPL10 1, aSHM Arthur et al. 2018
P2RY8 1 Lohr et al. 2012; Muppidi et al. 2014
PCBP1 1 Schmitz et al. 2012
PIM1 1, aSHM Burkhardt et al. 2022; L. Pasqualucci et al. 2001
PIM2 1, aSHM Arthur et al. 2018
POU2AF1 1, aSHM Krysiak et al. 2017
POU2F2 1 Krysiak et al. 2017; Zhang et al. 2013
PRDM1 1 Laura Pasqualucci et al. 2006
PTEN 1 Love et al. 2012
PTPRD 1
RB1 1 Zhang et al. 2014; Morin et al. 2013
RFX7 1 Grande et al. 2019
RHOA 1 Richter et al. 2012
RRAGC 1 Okosun et al. 2016
S1PR2 1, aSHM Muppidi et al. 2014; Morin et al. 2011
SETD1B 1 Reddy et al. 2017
SF3B1 1 Love et al. 2012
SGK1 1, aSHM Morin et al. 2011
SIN3A 1 Grande et al. 2019
SMARCA4 1 Zhang et al. 2013; Krysiak et al. 2017; Nadeu et al. 2020; Richter et al. 2012
SOCS1 1, aSHM Morin et al. 2011
SPEN 1 Rossi et al. 2012
STAT3 1 Ohgami et al. 2014
STAT6 1 Yildiz et al. 2015
TAF1 1 Morin et al. 2013
TBL1XR1 1 Mareschal et al. 2016
TET2 1 Panea et al. 2019; Albuquerque et al. 2017
TMEM30A 1 Morin et al. 2011
TMSB4X 1, aSHM Albuquerque et al. 2017
TNFAIP3 1 Compagno et al. 2009
TNFRSF14 1 Cheung et al. 2010
TOX 1 Reddy et al. 2017
TP53 1 Beà et al. 2013; Wilda et al. 2004; Morin et al. 2011
TRRAP 1 Parry et al. 2013
UBE2A 1 Reddy et al. 2017
UNC5C 1
USP7 1 Grande et al. 2019
VPS13B 1
WEE1 1 Schmitz et al. 2018
XPO1 1 Mareschal et al. 2016
ZC3H12A 1 Arthur et al. 2018
ZFP36L1 1, aSHM Morin et al. 2011; Panea et al. 2019
ZNF292 1 Zhang et al. 2013
ZNF608 1 Zhang et al. 2013; Krysiak et al. 2017

Tier 2 DLBCL genes

195 total

Gene Tier Relevant references
ABI3BP 2 Morin et al. 2013
ADAMTS1 2 Hübschmann et al. 2021
AICDA 2, aSHM Arthur et al. 2018
ANKRD12 2 Hübschmann et al. 2021
ANKRD17 2 Reddy et al. 2017
ARID1B 2 Reddy et al. 2017
ARID5B 2 Reddy et al. 2017
ATR 2 Reddy et al. 2017
BCL11A 2, aSHM
BCOR 2 Nadeu et al. 2020
BCR 2
BIRC3 2, aSHM Arthur et al. 2018; Beà et al. 2013
BLK 2, aSHM
BRINP3 2 Reddy et al. 2017
BTBD3 2 Reddy et al. 2017
CADPS2 2 Hübschmann et al. 2021
CBLB 2 Reddy et al. 2017
CCL4 2 Chapuy et al. 2018
CD22 2 Reddy et al. 2017
CD274 2 Morin et al. 2011
CD36 2 Laura Pasqualucci, Trifonov, et al. 2011
CD44 2, aSHM Arthur et al. 2018
CD74 2, aSHM Arthur et al. 2018
CDC73 2 Reddy et al. 2017; Love et al. 2012
CDH9 2 Morin et al. 2013
CHD1 2 Reddy et al. 2017
CHD8 2 Grande et al. 2019; Reddy et al. 2017
CHST2 2 Reddy et al. 2017
CNOT2 2 Hübschmann et al. 2021
CNTNAP5 2 Morin et al. 2013
COQ7 2 Chapuy et al. 2018
CRIP1 2 Chapuy et al. 2018
DAZAP1 2 Pararajalingam et al. 2020
DCAF6 2 Reddy et al. 2017
DDX10 2 Reddy et al. 2017
DHX16 2 Hübschmann et al. 2021
DICER1 2 Reddy et al. 2017
DNAH5 2 Morin et al. 2013
DNM2 2 Hübschmann et al. 2021
DNMT3A 2 Reddy et al. 2017
DOCK1 2 Chapuy et al. 2018
DSG4 2 Morin et al. 2013
EIF2AK3 2, aSHM
EZR 2, aSHM
FAM102A 2, aSHM
FAM38B 2 Morin et al. 2013
FANK1 2, aSHM
FAT4 2 Morin et al. 2013; Zhang et al. 2014
FCRL3 2, aSHM
FNBP1 2, aSHM
FNDC1 2 Morin et al. 2013
FOXC1 2 Schmitz et al. 2018
FOXP1 2, aSHM Reddy et al. 2017
FUBP1 2 Reddy et al. 2017
FUT5 2 Chapuy et al. 2018
GABRA2 2 Chapuy et al. 2018
GAK 2 Hübschmann et al. 2021
GNAS 2 Reddy et al. 2017
GOLGA5 2 Reddy et al. 2017
GPC5 2 Schmitz et al. 2018
GSG2 2 Schmitz et al. 2018
HDAC7 2 Morin et al. 2013
HIST1H2AG 2 Morin et al. 2013; Krysiak et al. 2017; Panea et al. 2019
HLA-DMA 2
HLA-DQA1 2 Hübschmann et al. 2021
HNF1B 2 Laura Pasqualucci, Trifonov, et al. 2011
HNRNPD 2
HNRNPH1 2, noncoding Pararajalingam et al. 2020
HRAS 2 Reddy et al. 2017
ID3 2 Richter et al. 2012; Schmitz et al. 2012
IER2 2 Morin et al. 2013
IFNGR1 2 Morin et al. 2013
IGLL5 2, aSHM Panea et al. 2019; Russler-Germain et al. 2023
IKBKB 2 Reddy et al. 2017
IKBKE 2 Hübschmann et al. 2021
IL16 2
IL6 2 Chapuy et al. 2018
INO80 2 Zhang et al. 2013
IRAG2 2, aSHM
IRF1 2, aSHM Hübschmann et al. 2021
JAK1 2 Zhang et al. 2013
JAK3 2 Zhang et al. 2013
JUNB 2 Reddy et al. 2017
KCMF1 2 Reddy et al. 2017
KLHL21 2 Schmitz et al. 2018
LAMA5 2 Schmitz et al. 2018
LAPTM5 2, aSHM Hübschmann et al. 2021
LIN54 2 Reddy et al. 2017
LPP 2, aSHM Arthur et al. 2018
LRP12 2 Hübschmann et al. 2021
LRRN3 2 Morin et al. 2013
LYN 2 Chapuy et al. 2018
MAGT1 2 Reddy et al. 2017
MALAT1 2, aSHM Arthur et al. 2018
MAP2K1 2 Louissaint et al. 2016; Shin et al. 2015
MAP4K4 2 Reddy et al. 2017
MARK1 2 Reddy et al. 2017
MCL1 2 Reddy et al. 2017; Panea et al. 2019
MECOM 2 Reddy et al. 2017
MET 2 Reddy et al. 2017
MIR142 2, aSHM Kwanhian et al. 2012; Grande et al. 2019
MIR155HG 2, aSHM
MPDZ 2 Morin et al. 2013
MSH2 2 Reddy et al. 2017
MSH6 2 Reddy et al. 2017
MYB 2 Reddy et al. 2017
MYBPC2 2 Schmitz et al. 2018
MYO1E 2, aSHM
N2RF2 2 Hübschmann et al. 2021
NANOG 2 Chapuy et al. 2018
NAV1 2 Chapuy et al. 2018
NCOA3 2, aSHM
NCOR1 2 Reddy et al. 2017
NCOR2 2 Schmitz et al. 2012
NEAT1 2, aSHM Arthur et al. 2018
NF1 2 Reddy et al. 2017
NFKB1 2
NFKB2 2 Reddy et al. 2017
NLRC5 2
NLRP5 2 Morin et al. 2013
NLRP8 2 Chapuy et al. 2018
ODZ3 2 Morin et al. 2013
P2RX5 2, aSHM Morin et al. 2013
PAPOLG 2 Schmitz et al. 2018
PASK 2 Morin et al. 2013
PAX5 2, aSHM L. Pasqualucci et al. 2001
PCDHB11 2 Morin et al. 2013
PCLO 2 Lohr et al. 2012
PDE4DIP 2 Chapuy et al. 2018
PDS5B 2 Morin et al. 2013; Hübschmann et al. 2021
PHF6 2 Reddy et al. 2017; Thomas et al. 2023
PIK3CD 2 Reddy et al. 2017
PIK3R1 2 Zhang et al. 2013; Panea et al. 2019
PKD1 2 Morin et al. 2013
PNPO 2 Hübschmann et al. 2021
POGZ 2 Morin et al. 2013
PPP1R9B 2
PRKCB 2 Morin et al. 2013
PRKDC 2 Hübschmann et al. 2021; Schmitz et al. 2018
PRPS1 2 Chapuy et al. 2018
PTMA 2, aSHM
PTPN1 2, aSHM
PTPN23 2 Morin et al. 2013
PTPN6 2 Reddy et al. 2017
PTPRK 2 Reddy et al. 2017
RAC2 2 Panea et al. 2019; Hübschmann et al. 2021
RAD9A 2 Chapuy et al. 2018
RARA 2 Reddy et al. 2017
RCC 2, aSHM
RFTN1 2, aSHM Arthur et al. 2018
RFXAP 2
RHEX 2, aSHM
RHOH 2, aSHM L. Pasqualucci et al. 2001
RUBCNL 2, aSHM
RUNX1 2 Reddy et al. 2017
SAMD9L 2 Morin et al. 2013
SARM1 2 Morin et al. 2013
SEL1L3 2, aSHM
SEPTIN9 2, aSHM
SERPINA9 2, aSHM Arthur et al. 2018
SETD2 2 Zhang et al. 2013
SETD5 2 Reddy et al. 2017
SIAH2 2 Hübschmann et al. 2021
SLC34A2 2 Hübschmann et al. 2021
SMEK1 2 Chapuy et al. 2018
SRRM2 2 Russler-Germain et al. 2023; Morin et al. 2013
ST6GAL1 2, aSHM Arthur et al. 2018
STAT5B 2 Zhang et al. 2013
SYK 2 Reddy et al. 2017
SYPL1 2 Morin et al. 2013
TAP1 2 Schmitz et al. 2018
TBC1D4 2, aSHM Arthur et al. 2018
TCL1A 2, aSHM Grande et al. 2019
TGFBR2 2 Reddy et al. 2017
TIPARP 2 Reddy et al. 2017
TLR2 2 Beà et al. 2013; Chapuy et al. 2018
TRAF3 2 Laura Pasqualucci, Trifonov, et al. 2011
TRAF6 2 Hübschmann et al. 2021
TRIP12 2
UBE2J1 2, aSHM
UBR5 2 Zhang et al. 2013; Pararajalingam et al. 2020
UNC5B 2 Hübschmann et al. 2021
UNC5D 2
WAC 2 Reddy et al. 2017
WDFY3 2 Morin et al. 2013
WNK1 2 Thomas et al. 2023; Hübschmann et al. 2021
XBP1 2, aSHM
YY1 2 Reddy et al. 2017
ZBTB7A 2 Burkhardt et al. 2022; Reddy et al. 2017
ZCCHC7 2, aSHM Arthur et al. 2018
ZEB2 2 Zhang et al. 2013
ZFAT 2 Reddy et al. 2017
ZFX 2 Reddy et al. 2017
ZNF217 2 Hübschmann et al. 2021
ZNF423 2 Chapuy et al. 2018

References

Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 5: 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 1: 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 45: 18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 EBF1 in Hodgkin Lymphoma.” Leukemia 27 3: 671–79. https://doi.org/10.1038/leu.2012.280.
Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance of Molecular Characteristics in Burkitt Lymphoma Differs According to Age.” Nature Communications 13 1: 3881. https://doi.org/10.1038/s41467-022-31355-8.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 5: 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 22: 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 7247: 717–21. https://doi.org/10.1038/nature07968.
Duns, Gerben, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021. “Characterization of DLBCL with a PMBL Gene Expression Signature.” Blood 138 2: 136–48. https://doi.org/10.1182/blood.2020007683.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 12: 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 7: 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 6: 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. “Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 11: 1308–19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717795/.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 4: 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Kwanhian, Wiyada, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, et al. 2012. “MicroRNA-142 Is Mutated in about 20% of Diffuse Large B-cell Lymphoma.” Cancer Medicine 1 2: 141–55. https://doi.org/10.1002/cam4.29.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 6: 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 5870: 1676–79.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma DLBCL by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 10: 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 8: 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 12: 1321–25. https://doi.org/10.1038/ng.2468.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 3: 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 9: 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering EZH2 Tyr641 in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 2: 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 7360: 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 7: 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Muppidi, J., R. Schmitz, Jesse A. Green, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, S. Braun, et al. 2014. “Loss of Signaling via Gα13 in Germinal Center B Cell-Derived Lymphoma.” Nature 516: 254–58. https://doi.org/10.1038/nature13765.
Nadeu, F., D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, et al. 2020. “Genomic and Epigenomic Insights into the Origin, Pathogenesis and Clinical Behavior of Mantle Cell Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2020005289.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active MYD88 Mutations in Human Lymphoma.” Nature 470 7332: 115–19. https://doi.org/10.1038/nature09671.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel A. Arber. 2014. “STAT3 Mutations Are Present in Aggressive B-cell Lymphomas Including a Subset of Diffuse Large B-cell Lymphomas with CD30 Expression.” Haematologica 99 7: e105–107. https://doi.org/10.3324/haematol.2013.101543.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 2: 183–88. https://doi.org/10.1038/ng.3473.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 5: 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 12: e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Mara Compagno, Jane Houldsworth, Stefano Monti, Adina Grunn, Subhadra V Nandula, Jon C Aster, Vundavally V Murty, Margaret A Shipp, and Riccardo Dalla-Favera. 2006. “Inactivation of the PRDM1/BLIMP1 Gene in Diffuse Large B Cell Lymphoma.” J Exp Med 203 2: 311–17.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 7337: 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 9: 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 6844: 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 2: 481–494.e15.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 12: 1316–20. https://doi.org/10.1038/ng.2469.
Rossi, Davide, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, et al. 2012. “The Coding Genome of Splenic Marginal Zone Lymphoma: Activation of NOTCH2 and Other Pathways Regulating Marginal Zone Development.” The Journal of Experimental Medicine 209 9: 1537–51. https://doi.org/10.1084/jem.20120904.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 13: 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 15: 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 7418: 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/CD95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 5: 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF V600E and MAP2K1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 2: 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated BCL2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 1: 229–37.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 8: 904–16. https://doi.org/10.1182/blood.2022016534.
Tiacci, Enrico, Vladimir Trifonov, Gianluca Schiavoni, Antony Holmes, Wolfgang Kern, Maria Paola Martelli, Alessandra Pucciarini, et al. 2011. “BRAF Mutations in Hairy-Cell Leukemia.” The New England Journal of Medicine 364 24: 2305–15. https://doi.org/10.1056/NEJMoa1014209.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. “NOTCH2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 7: 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 3: 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent CARD11 Mutations.” Oncotarget 7 25: 38180–90. https://doi.org/10.18632/oncotarget.9500.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating STAT6 Mutations in Follicular Lymphoma.” Blood 125 4: 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” January.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 19: 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent FOXO1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 14: 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.