DLBCL genes

Origins of DLBCL genes

--- config: sankey: showValues: false linkColor: target width: 800 height: 1000 nodeAlignment: right --- sankey-beta Morin 2013, DLBCL Tier 1, 11 Morin 2013, DLBCL Tier 2, 29 Morin 2016, DLBCL Tier 1, 2 Mareschal 2016, DLBCL Tier 1, 2 Arthur 2018, DLBCL Tier 1, 8 Arthur 2018, DLBCL Tier 2, 12 Pasqualucci 2001, DLBCL Tier 1, 2 Pasqualucci 2001, DLBCL Tier 2, 2 Albuquerque 2017, DLBCL Tier 1, 3 Lohr 2012, DLBCL Tier 1, 3 Lohr 2012, DLBCL Tier 2, 1 Schmitz 2018, DLBCL Tier 1, 7 Schmitz 2018, DLBCL Tier 2, 9 Zhang 2013, DLBCL Tier 1, 11 Zhang 2013, DLBCL Tier 2, 8 Morin 2011, DLBCL Tier 1, 24 Morin 2011, DLBCL Tier 2, 1 Reddy 2017, DLBCL Tier 1, 7 Reddy 2017, DLBCL Tier 2, 53 Pasqualucci 2011, DLBCL Tier 1, 3 Pasqualucci 2011, DLBCL Tier 2, 4 Chapuy 2018, DLBCL Tier 1, 2 Chapuy 2018, DLBCL Tier 2, 17 Pasqualucci 2011, DLBCL Tier 1, 2 Hubschmann 2021, DLBCL Tier 1, 3 Hubschmann 2021, DLBCL Tier 2, 20 Pararajalingam 2020, DLBCL Tier 2, 2 DLBCL, Sanger, 4 Sanger, Pasqualucci 2001, 4 DLBCL, exome, 2 exome, Mareschal 2016, 2 DLBCL, WGS, 20 WGS, Arthur 2018, 20 DLBCL, exome, 2 exome, Morin 2016, 2 DLBCL, WGS, 40 WGS, Morin 2013, 40 DLBCL, exome, 3 exome, Albuquerque 2017, 3 DLBCL, exome, 4 exome, Lohr 2012, 4 DLBCL, exome, 60 exome, Reddy 2017, 60 DLBCL, exome, 16 exome, Schmitz 2018, 16 DLBCL, exome, 19 exome, Zhang 2013, 19 DLBCL, RNA-seq/WGS, 25 RNA-seq/WGS, Morin 2011, 25 DLBCL, exome, 2 exome, Pasqualucci 2011, 2 DLBCL, WGS/exome, 2 WGS/exome, Pararajalingam 2020, 2 DLBCL, WGS, 23 WGS, Hubschmann 2021, 23 DLBCL, exome, 19 exome, Chapuy 2018, 19 DLBCL, exome, 7 exome, Pasqualucci 2011, 7

Tier 1 DLBCL genes

128 total

Gene Tier Relevant references
ACTB 1, aSHM Wienand et al. 2019; Lohr et al. 2012
ACTG1 1, aSHM Spina et al. 2016; Desch et al. 2020; Hübschmann et al. 2021
ARID1A 1 Rossi et al. 2012; Wienand et al. 2019; Love et al. 2012; Zhang et al. 2013; Krysiak et al. 2017
ATM 1 Braggio et al. 2012; Beà et al. 2013; Reddy et al. 2017
B2M 1 Pararajalingam et al. 2020; Reichel et al. 2015; Morin et al. 2011
BCL10 1 Morin et al. 2011; Russler-Germain et al. 2023; Spina et al. 2016
BCL2 1, aSHM Sarkozy et al. 2021; Tanaka et al. 1992; Burkhardt et al. 2022; Morin et al. 2011
BCL6 1, aSHM Morin et al. 2011; Love et al. 2012
BCL7A 1, aSHM Reichel et al. 2015; Krysiak et al. 2017; Arthur et al. 2018; Grande et al. 2019
BIRC6 1 Reddy et al. 2017; Sarkozy et al. 2021
BRAF 1 Love et al. 2012; Tiacci et al. 2011
BTG1 1, aSHM Morin et al. 2011; Burkhardt et al. 2022; Sarkozy et al. 2021
BTG2 1, aSHM Morin et al. 2011; Love et al. 2012
BTK 1 Krysiak et al. 2017; Albuquerque et al. 2017
CARD11 1 Wu et al. 2016; Panea et al. 2019; Lenz et al. 2008; Yan et al. 2012; Morin et al. 2011
CCND3 1 Jallades et al. 2017; Richter et al. 2012; Desch et al. 2020; Morin et al. 2011
CD58 1 Morin et al. 2011; Schneider et al. 2015
CD70 1 Russler-Germain et al. 2023; Morin et al. 2011
CD79B 1 Morin et al. 2011; Panea et al. 2019
CD83 1, aSHM Russler-Germain et al. 2023; Morin et al. 2013; Duns et al. 2021; Panea et al. 2019
CDKN2A 1 Grande et al. 2019; Spina et al. 2016; Morin et al. 2013
CIITA 1, aSHM Mottok et al. 2015; Morin et al. 2011
CREBBP 1 Duns et al. 2021; Laura Pasqualucci, Dominguez-Sola, et al. 2011; Love et al. 2012; Parry et al. 2013
CXCR4 1, aSHM Khodabakhshi et al. 2012; Panea et al. 2019; Krysiak et al. 2017
CXCR5 1 Schmitz et al. 2018; Mottok et al. 2019
DDX3X 1 Schmitz et al. 2012, 2018; Mottok et al. 2019
DTX1 1, aSHM Panea et al. 2019; Gomez et al. 2023; Schmitz et al. 2018; Rossi et al. 2012
DUSP2 1, aSHM Duns et al. 2021; Morin et al. 2013
EBF1 1, aSHM Reichel et al. 2015; Bohle et al. 2013; Thomas et al. 2023
EEF1A1 1 Hübschmann et al. 2021; Reichel et al. 2015
EP300 1 Rossi et al. 2012; Panea et al. 2019; Laura Pasqualucci, Dominguez-Sola, et al. 2011
ETS1 1, aSHM Panea et al. 2019; Morin et al. 2011
ETV6 1, aSHM Arthur et al. 2018
EZH2 1 Morin et al. 2010; Mottok et al. 2019; Love et al. 2012
FAS 1 Scholl et al. 2007; Spina et al. 2016
FBXO11 1 Richter et al. 2012; Hübschmann et al. 2021; Parry et al. 2013
FBXW7 1 Zhang et al. 2013
FOXO1 1 Schmitz et al. 2012; Morin et al. 2011; Duns et al. 2021
GNA13 1 Love et al. 2012; Morin et al. 2011; Reichel et al. 2015
GNAI2 1 Grande et al. 2019; Morin et al. 2013
GRB2 1 Panea et al. 2019; Laura Pasqualucci, Trifonov, et al. 2011
GRHPR 1, aSHM Arthur et al. 2018
HIST1H1B 1, aSHM Krysiak et al. 2017; Sarkozy et al. 2021; Chapuy et al. 2018
HIST1H1C 1, aSHM Morin et al. 2011; Panea et al. 2019
HIST1H1D 1, aSHM Krysiak et al. 2017; Jallades et al. 2017; Morin et al. 2013
HIST1H1E 1, aSHM Morin et al. 2013; Reichel et al. 2015; Grande et al. 2019; Krysiak et al. 2017
HIST1H2AC 1, aSHM Krysiak et al. 2017; Morin et al. 2013
HIST1H2AM 1, aSHM Panea et al. 2019; Krysiak et al. 2017
HIST1H2BC 1, aSHM Krysiak et al. 2017; Mottok et al. 2019; Reddy et al. 2017
HIST1H2BK 1, aSHM Panea et al. 2019; Rossi et al. 2012
HIST1H3B 1, aSHM Zhang et al. 2013; Reichel et al. 2015
HIST2H2BE 1, aSHM Schmitz et al. 2018
HLA-A 1 Desch et al. 2020
HLA-B 1 Wienand et al. 2019
HLA-C 1 Gomez et al. 2023
HLA-DMB 1
HNRNPU 1, aSHM Panea et al. 2019; Reddy et al. 2017
HVCN1 1 Krysiak et al. 2017
IKZF3 1 Morin et al. 2013; Panea et al. 2019
IL4R 1, aSHM Duns et al. 2021; Viganò et al. 2018
IRF4 1, aSHM Mottok et al. 2019; Morin et al. 2011
IRF8 1, aSHM Panea et al. 2019; Morin et al. 2011; Mottok et al. 2019
ITPKB 1, aSHM Schmitz et al. 2018; Reichel et al. 2015
KLF2 1, aSHM Desch et al. 2020; Jallades et al. 2017; Laura Pasqualucci, Trifonov, et al. 2011
KLHL14 1 Zhang et al. 2013
KLHL6 1, aSHM Panea et al. 2019; Ganapathi et al. 2016; Morin et al. 2011
KMT2C 1 Zhang et al. 2014; Sarkozy et al. 2021; Zhou et al. 2019; Zhang et al. 2013
KMT2D 1 Desch et al. 2020; Rossi et al. 2012; Grande et al. 2019; Morin et al. 2011; Beà et al. 2013
KRAS 1 Lohr et al. 2012
LCOR 1 Arthur et al. 2018
LTB 1, aSHM Desch et al. 2020; Chapuy et al. 2018; Panea et al. 2019
MEF2B 1, aSHM Beà et al. 2013; Morin et al. 2011
MEF2C 1, aSHM Arthur et al. 2018
MGA 1 Jallades et al. 2017; Zhang et al. 2013
MPEG1 1 Morin et al. 2013
MS4A1 1, aSHM Rushton et al. 2020; Mottok et al. 2019
MTOR 1 Zhang et al. 2013; Panea et al. 2019
MYC 1, aSHM L. Pasqualucci et al. 2001; Jallades et al. 2017; Duns et al. 2021; Johnston and Carroll 1992
MYD88 1 Yan et al. 2012; Ngo et al. 2011
NFKBIA 1 Lake et al. 2009; Wienand et al. 2019; Russler-Germain et al. 2023
NFKBIE 1 Morin et al. 2016; Pararajalingam et al. 2020; Mansouri et al. 2016
NFKBIZ 1, noncoding Morin et al. 2016
NOL9 1, aSHM Spina et al. 2016; Schmitz et al. 2018
NOTCH1 1 Beà et al. 2013; Laura Pasqualucci, Trifonov, et al. 2011; Love et al. 2012; Rossi et al. 2012
NOTCH2 1 Rossi et al. 2012; Panea et al. 2019; Beà et al. 2013; Trøen et al. 2008
OSBPL10 1, aSHM Arthur et al. 2018
P2RY8 1 Muppidi et al. 2014; Lohr et al. 2012
PIM1 1, aSHM L. Pasqualucci et al. 2001; Duns et al. 2021; Burkhardt et al. 2022
PIM2 1, aSHM Arthur et al. 2018; Reichel et al. 2015
POU2AF1 1, aSHM Krysiak et al. 2017
POU2F2 1 Krysiak et al. 2017; Zhang et al. 2013
PRDM1 1 Laura Pasqualucci et al. 2006
PTEN 1 Love et al. 2012
PTPRD 1 Spina et al. 2016
RB1 1 Zhang et al. 2014; Morin et al. 2013
RFX7 1 Grande et al. 2019
RHOA 1 Richter et al. 2012
RRAGC 1 Okosun et al. 2016
S1PR2 1, aSHM Morin et al. 2011; Muppidi et al. 2014
SETD1B 1 Reddy et al. 2017
SF3B1 1 Love et al. 2012
SGK1 1, aSHM Duns et al. 2021; Morin et al. 2011
SIN3A 1 Grande et al. 2019; Rossi et al. 2012
SMARCA4 1 Zhang et al. 2013; Nadeu et al. 2020; Krysiak et al. 2017; Richter et al. 2012
SOCS1 1, aSHM Weniger et al. 2006; Morin et al. 2011
SPEN 1 Sarkozy et al. 2021; Rossi et al. 2012
STAT3 1 Ohgami et al. 2014
STAT6 1 Yildiz et al. 2015; Ritz et al. 2009
TAF1 1 Spina et al. 2016; Morin et al. 2013
TBL1XR1 1 Rossi et al. 2012; Mareschal et al. 2016
TET2 1 Albuquerque et al. 2017; Panea et al. 2019
TMEM30A 1 Morin et al. 2011
TMSB4X 1, aSHM Albuquerque et al. 2017
TNFAIP3 1 Schmitz et al. 2009; Rossi et al. 2011; Compagno et al. 2009
TNFRSF14 1 Cheung et al. 2010; Spina et al. 2016
TOX 1 Reddy et al. 2017
TP53 1 Wilda et al. 2004; Rossi et al. 2012; Tiacci et al. 2018; Beà et al. 2013; Morin et al. 2011
TRRAP 1 Rossi et al. 2012; Parry et al. 2013
UBE2A 1 Reddy et al. 2017; Reichel et al. 2015
UNC5C 1
USP7 1 Grande et al. 2019
VPS13B 1
WEE1 1 Schmitz et al. 2018; Reichel et al. 2015
XPO1 1 Jardin et al. 2016; Mareschal et al. 2016
ZC3H12A 1 Arthur et al. 2018
ZFP36L1 1, aSHM Morin et al. 2011; Reichel et al. 2015; Panea et al. 2019
ZNF292 1 Zhang et al. 2013
ZNF608 1, aSHM Zhang et al. 2013; Krysiak et al. 2017

Tier 2 DLBCL genes

198 total

Gene Tier Relevant references
ABI3BP 2 Morin et al. 2013
ADAMTS1 2 Hübschmann et al. 2021
AICDA 2, aSHM Arthur et al. 2018
ANKRD12 2 Hübschmann et al. 2021
ANKRD17 2 Reddy et al. 2017
ARID1B 2 Reddy et al. 2017
ARID5B 2 Reddy et al. 2017; Gomez et al. 2023
ATR 2 Reddy et al. 2017
BCL11A 2, aSHM
BCOR 2 Nadeu et al. 2020; Jallades et al. 2017
BCR 2, aSHM
BIRC3 2, aSHM Duns et al. 2021; Rossi et al. 2011; Arthur et al. 2018; Beà et al. 2013
BLK 2, aSHM
BRINP3 2 Reddy et al. 2017
BTBD3 2 Reddy et al. 2017
CADPS2 2 Hübschmann et al. 2021
CASP8 2 Reddy et al. 2017
CBLB 2 Reddy et al. 2017
CCL4 2 Chapuy et al. 2018
CD22 2 Reddy et al. 2017
CD274 2 Morin et al. 2011
CD36 2 Laura Pasqualucci, Trifonov, et al. 2011
CD44 2, aSHM Arthur et al. 2018
CD74 2, aSHM Arthur et al. 2018
CDC73 2 Reddy et al. 2017; Love et al. 2012
CDH9 2 Morin et al. 2013
CHD1 2 Reddy et al. 2017
CHD8 2 Grande et al. 2019; Reddy et al. 2017
CHST2 2 Reddy et al. 2017
CNOT2 2 Hübschmann et al. 2021
CNTNAP5 2 Morin et al. 2013
COQ7 2 Chapuy et al. 2018
CRIP1 2 Chapuy et al. 2018
DAZAP1 2 Pararajalingam et al. 2020
DCAF6 2 Reddy et al. 2017
DDX10 2 Reddy et al. 2017
DHX16 2 Hübschmann et al. 2021
DICER1 2 Reddy et al. 2017
DNAH5 2 Morin et al. 2013; Jallades et al. 2017
DNM2 2 Hübschmann et al. 2021
DNMT3A 2 Reddy et al. 2017
DOCK1 2 Chapuy et al. 2018
DSG4 2 Morin et al. 2013
EIF2AK3 2, aSHM
EZR 2, aSHM Desch et al. 2020
FAM102A 2, aSHM
FAM38B 2 Morin et al. 2013
FANK1 2, aSHM
FAT4 2 Parry et al. 2013; Morin et al. 2013; Zhang et al. 2014
FCRL3 2, aSHM
FNBP1 2, aSHM
FNDC1 2 Morin et al. 2013
FOXC1 2 Schmitz et al. 2018
FOXP1 2, aSHM Reddy et al. 2017
FUBP1 2 Reddy et al. 2017
FUT5 2 Chapuy et al. 2018
GABRA2 2 Chapuy et al. 2018
GAK 2 Hübschmann et al. 2021
GNAS 2 Reddy et al. 2017
GOLGA5 2 Reddy et al. 2017
GPC5 2 Schmitz et al. 2018
GSG2 2 Schmitz et al. 2018
HDAC7 2 Morin et al. 2013
HIST1H2AG 2, aSHM Morin et al. 2013; Rossi et al. 2012; Panea et al. 2019; Krysiak et al. 2017
HLA-DMA 2
HLA-DQA1 2 Hübschmann et al. 2021
HNF1B 2 Laura Pasqualucci, Trifonov, et al. 2011
HNRNPD 2
HNRNPH1 2, noncoding Pararajalingam et al. 2020
HRAS 2 Jallades et al. 2017; Reddy et al. 2017
ID3 2 Richter et al. 2012; Spina et al. 2016; Schmitz et al. 2012
IER2 2 Morin et al. 2013
IFNGR1 2 Morin et al. 2013
IGLL5 2, aSHM Russler-Germain et al. 2023; Desch et al. 2020; Panea et al. 2019
IKBKB 2 Reddy et al. 2017; Rossi et al. 2011; Wienand et al. 2019
IKBKE 2 Hübschmann et al. 2021
IL16 2
IL6 2 Chapuy et al. 2018
INO80 2 Zhang et al. 2013
IRAG2 2, aSHM
IRF1 2, aSHM Hübschmann et al. 2021
JAK1 2 Zhang et al. 2013; Mottok et al. 2019
JAK3 2 Zhang et al. 2013
JUNB 2 Reddy et al. 2017; Mottok et al. 2019
KCMF1 2 Reddy et al. 2017
KLHL21 2 Schmitz et al. 2018
LAMA5 2 Schmitz et al. 2018
LAPTM5 2, aSHM Hübschmann et al. 2021
LIN54 2 Reddy et al. 2017
LPP 2, aSHM Arthur et al. 2018
LRP12 2 Hübschmann et al. 2021
LRRN3 2 Sarkozy et al. 2021; Morin et al. 2013
LYN 2 Chapuy et al. 2018
MAGT1 2 Reddy et al. 2017
MALAT1 2, aSHM Arthur et al. 2018
MAP2K1 2 Shin et al. 2015; Louissaint et al. 2016
MAP4K4 2 Reddy et al. 2017
MARK1 2 Reddy et al. 2017
MCL1 2 Panea et al. 2019; Reddy et al. 2017; Duns et al. 2021
MECOM 2 Reddy et al. 2017
MET 2 Reddy et al. 2017
MIR142 2, aSHM Grande et al. 2019; Kwanhian et al. 2012
MIR155HG 2, aSHM
MPDZ 2 Reichel et al. 2015; Morin et al. 2013
MSH2 2 Reddy et al. 2017
MSH6 2 Reddy et al. 2017
MYB 2 Reddy et al. 2017; Desch et al. 2020
MYBPC2 2 Schmitz et al. 2018
MYO1E 2, aSHM
MYOM2 2 Laura Pasqualucci, Trifonov, et al. 2011
N2RF2 2 Hübschmann et al. 2021
NANOG 2 Chapuy et al. 2018
NAV1 2 Chapuy et al. 2018
NCOA3 2, aSHM
NCOR1 2 Reddy et al. 2017
NCOR2 2 Schmitz et al. 2012; Spina et al. 2016; Sarkozy et al. 2021
NEAT1 2, aSHM Arthur et al. 2018
NF1 2 Reddy et al. 2017
NFKB1 2
NFKB2 2 Reddy et al. 2017; Mottok et al. 2019
NLRC5 2
NLRP5 2 Morin et al. 2013
NLRP8 2 Chapuy et al. 2018
ODZ3 2 Morin et al. 2013
P2RX5 2, aSHM Morin et al. 2013
PAPOLG 2 Schmitz et al. 2018
PASK 2 Morin et al. 2013
PAX5 2, aSHM L. Pasqualucci et al. 2001
PCBP1 2 Schmitz et al. 2012
PCDHB11 2 Morin et al. 2013
PCLO 2 Lohr et al. 2012
PDE4DIP 2 Chapuy et al. 2018
PDS5B 2 Hübschmann et al. 2021; Morin et al. 2013
PHF6 2 Reddy et al. 2017; Thomas et al. 2023
PIK3CD 2 Reddy et al. 2017
PIK3R1 2 Zhang et al. 2013; Panea et al. 2019
PKD1 2 Morin et al. 2013
PNPO 2 Hübschmann et al. 2021
POGZ 2 Morin et al. 2013
PPP1R9B 2
PRKCB 2 Morin et al. 2013
PRKDC 2 Hübschmann et al. 2021; Schmitz et al. 2018
PRPS1 2 Chapuy et al. 2018
PTMA 2, aSHM
PTPN1 2, aSHM Gunawardana et al. 2014
PTPN23 2 Morin et al. 2013
PTPN6 2 Reddy et al. 2017
PTPRK 2 Reddy et al. 2017
RAC2 2 Hübschmann et al. 2021; Panea et al. 2019
RAD9A 2 Chapuy et al. 2018
RARA 2 Reddy et al. 2017
RCC 2, aSHM
RFTN1 2, aSHM Duns et al. 2021; Arthur et al. 2018
RFXAP 2
RHEX 2, aSHM
RHOH 2, aSHM L. Pasqualucci et al. 2001
RUBCNL 2, aSHM
RUNX1 2 Reddy et al. 2017
SAMD9L 2 Morin et al. 2013
SARM1 2 Morin et al. 2013
SEL1L3 2, aSHM
SEPTIN9 2, aSHM
SERPINA9 2, aSHM Arthur et al. 2018
SETD2 2 Zhang et al. 2013
SETD5 2 Reddy et al. 2017; Tiacci et al. 2018
SIAH2 2 Reichel et al. 2015; Hübschmann et al. 2021
SLC34A2 2 Hübschmann et al. 2021
SMEK1 2 Chapuy et al. 2018
SRRM2 2 Russler-Germain et al. 2023; Morin et al. 2013
ST6GAL1 2, aSHM Arthur et al. 2018
STAT5B 2 Zhang et al. 2013; Tiacci et al. 2018
SYK 2 Reddy et al. 2017
SYPL1 2 Morin et al. 2013
TAP1 2 Schmitz et al. 2018
TBC1D4 2, aSHM Arthur et al. 2018
TCL1A 2, aSHM Grande et al. 2019
TGFBR2 2 Reddy et al. 2017
TIPARP 2 Reddy et al. 2017
TLR2 2 Chapuy et al. 2018; Beà et al. 2013
TRAF3 2 Rossi et al. 2011; Otto et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011
TRAF6 2 Hübschmann et al. 2021
TRIP12 2
UBE2J1 2, aSHM
UBR5 2 Pararajalingam et al. 2020; Zhang et al. 2013
UNC5B 2 Hübschmann et al. 2021
UNC5D 2
WAC 2 Rossi et al. 2012; Reddy et al. 2017
WDFY3 2 Morin et al. 2013
WNK1 2 Hübschmann et al. 2021; Thomas et al. 2023; Jallades et al. 2017
XBP1 2, aSHM
YY1 2 Reddy et al. 2017
ZBTB7A 2 Burkhardt et al. 2022; Reddy et al. 2017
ZCCHC7 2, aSHM Arthur et al. 2018
ZEB2 2 Zhang et al. 2013
ZFAT 2 Reddy et al. 2017
ZFX 2 Reddy et al. 2017
ZNF217 2 Hübschmann et al. 2021; Reichel et al. 2015
ZNF423 2 Chapuy et al. 2018

References

Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 5: 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 1: 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 45: 18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 EBF1 in Hodgkin Lymphoma.” Leukemia 27 3: 671–79. https://doi.org/10.1038/leu.2012.280.
Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified Common and Disease-Specific Abnormalities.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 25 5: 651–60. https://doi.org/10.1038/modpathol.2011.213.
Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance of Molecular Characteristics in Burkitt Lymphoma Differs According to Age.” Nature Communications 13 1: 3881. https://doi.org/10.1038/s41467-022-31355-8.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 5: 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 22: 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 7247: 717–21. https://doi.org/10.1038/nature07968.
Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020. “Genotyping Circulating Tumor DNA of Pediatric Hodgkin Lymphoma.” Leukemia 34 1: 151–66. https://doi.org/10.1038/s41375-019-0541-6.
Duns, Gerben, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021. “Characterization of DLBCL with a PMBL Gene Expression Signature.” Blood 138 2: 136–48. https://doi.org/10.1182/blood.2020007683.
Ganapathi, Karthik A., Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain, Jinli Chen, Luciano Cascione, Odelia Nahum, et al. 2016. “The Genetic Landscape of Dural Marginal Zone Lymphomas.” Oncotarget 7 28: 43052–61. https://doi.org/10.18632/oncotarget.9678.
Gomez, Felicia, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, et al. 2023. “Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.” Cancer Research Communications 3 11: 2312–30. https://doi.org/10.1158/2767-9764.CRC-23-0140.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 12: 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Gunawardana, Jay, Fong Chun Chan, Adèle Telenius, Bruce Woolcock, Robert Kridel, King L. Tan, Susana Ben-Neriah, et al. 2014. “Recurrent Somatic Mutations of PTPN1 in Primary Mediastinal B Cell Lymphoma and Hodgkin Lymphoma.” Nature Genetics 46 4: 329–35. https://doi.org/10.1038/ng.2900.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 7: 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017. “Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of KLF2, TNFAIP3 and MYD88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica 102 10: 1758–66. https://doi.org/10.3324/haematol.2016.160192.
Jardin, Fabrice, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, et al. 2016. “Recurrent Mutations of the Exportin 1 Gene XPO1 and Their Impact on Selective Inhibitor of Nuclear Export Compounds Sensitivity in Primary Mediastinal B-cell Lymphoma.” American Journal of Hematology 91 9: 923–30. https://doi.org/10.1002/ajh.24451.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 6: 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. “Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 11: 1308–19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717795/.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 4: 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Kwanhian, Wiyada, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, et al. 2012. “MicroRNA-142 Is Mutated in about 20% of Diffuse Large B-cell Lymphoma.” Cancer Medicine 1 2: 141–55. https://doi.org/10.1002/cam4.29.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 6: 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 5870: 1676–79.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma DLBCL by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 10: 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 8: 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 12: 1321–25. https://doi.org/10.1038/ng.2468.
Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent NFKBIE Deletions Are Associated with Poor Outcome in Primary Mediastinal B-cell Lymphoma.” Blood 128 23: 2666–70. https://doi.org/10.1182/blood-2016-03-704528.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 3: 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 9: 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering EZH2 Tyr641 in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 2: 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 7360: 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 7: 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Mottok, Anja, Stacy S. Hung, Elizabeth A. Chavez, Bruce Woolcock, Adèle Telenius, Lauren C. Chong, Barbara Meissner, et al. 2019. “Integrative Genomic Analysis Identifies Key Pathogenic Mechanisms in Primary Mediastinal Large B-cell Lymphoma.” Blood 134 10: 802–13. https://doi.org/10.1182/blood.2019001126.
Mottok, Anja, Bruce Woolcock, Fong Chun Chan, King Mong Tong, Lauren Chong, Pedro Farinha, Adèle Telenius, et al. 2015. “Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.” Cell Reports 13 7: 1418–31. https://doi.org/10.1016/j.celrep.2015.10.008.
Muppidi, J., R. Schmitz, Jesse A. Green, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, S. Braun, et al. 2014. “Loss of Signaling via Gα13 in Germinal Center B Cell-Derived Lymphoma.” Nature 516: 254–58. https://doi.org/10.1038/nature13765.
Nadeu, F., D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, et al. 2020. “Genomic and Epigenomic Insights into the Origin, Pathogenesis and Clinical Behavior of Mantle Cell Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2020005289.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active MYD88 Mutations in Human Lymphoma.” Nature 470 7332: 115–19. https://doi.org/10.1038/nature09671.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel A. Arber. 2014. “STAT3 Mutations Are Present in Aggressive B-cell Lymphomas Including a Subset of Diffuse Large B-cell Lymphomas with CD30 Expression.” Haematologica 99 7: e105–107. https://doi.org/10.3324/haematol.2013.101543.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 2: 183–88. https://doi.org/10.1038/ng.3473.
Otto, Claudia, Maciej Giefing, Anne Massow, Inga Vater, Stefan Gesk, Matthias Schlesner, Julia Richter, et al. 2012. “Genetic Lesions of the TRAF3 and MAP3K14 Genes in Classical Hodgkin Lymphoma.” British Journal of Haematology 157 6: 702–8. https://doi.org/10.1111/j.1365-2141.2012.09113.x.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 5: 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 12: e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Mara Compagno, Jane Houldsworth, Stefano Monti, Adina Grunn, Subhadra V Nandula, Jon C Aster, Vundavally V Murty, Margaret A Shipp, and Riccardo Dalla-Favera. 2006. “Inactivation of the PRDM1/BLIMP1 Gene in Diffuse Large B Cell Lymphoma.” J Exp Med 203 2: 311–17.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 7337: 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 9: 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 6844: 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 2: 481–494.e15.
Reichel, Jonathan, Amy Chadburn, Paul G. Rubinstein, Lisa Giulino-Roth, Wayne Tam, Yifang Liu, Rafael Gaiolla, et al. 2015. “Flow Sorting and Exome Sequencing Reveal the Oncogenome of Primary Hodgkin and Reed-Sternberg Cells.” Blood 125 7: 1061–72. https://doi.org/10.1182/blood-2014-11-610436.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 12: 1316–20. https://doi.org/10.1038/ng.2469.
Ritz, Olga, Chrystelle Guiter, Flavia Castellano, Karola Dorsch, Julia Melzner, Jean-Philippe Jais, Gwendoline Dubois, Philippe Gaulard, Peter Möller, and Karen Leroy. 2009. “Recurrent Mutations of the STAT6 DNA Binding Domain in Primary Mediastinal B-cell Lymphoma.” Blood 114 6: 1236–42. https://doi.org/10.1182/blood-2009-03-209759.
Rossi, Davide, Silvia Deaglio, David Dominguez-Sola, Silvia Rasi, Tiziana Vaisitti, Claudio Agostinelli, Valeria Spina, et al. 2011. “Alteration of BIRC3 and Multiple Other NF-κB Pathway Genes in Splenic Marginal Zone Lymphoma.” Blood 118 18: 4930–34. https://doi.org/10.1182/blood-2011-06-359166.
Rossi, Davide, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, et al. 2012. “The Coding Genome of Splenic Marginal Zone Lymphoma: Activation of NOTCH2 and Other Pathways Regulating Marginal Zone Development.” The Journal of Experimental Medicine 209 9: 1537–51. https://doi.org/10.1084/jem.20120904.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 13: 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Sarkozy, Clémentine, Stacy S. Hung, Elizabeth A. Chavez, Gerben Duns, Katsuyoshi Takata, Lauren C. Chong, Tomohiro Aoki, et al. 2021. “Mutational Landscape of Gray Zone Lymphoma.” Blood 137 13: 1765–76. https://doi.org/10.1182/blood.2020007507.
Schmitz, Roland, Martin-Leo Hansmann, Verena Bohle, Jose Ignacio Martin-Subero, Sylvia Hartmann, Gunhild Mechtersheimer, Wolfram Klapper, et al. 2009. “TNFAIP3 A20 Is a Tumor Suppressor Gene in Hodgkin Lymphoma and Primary Mediastinal B Cell Lymphoma.” The Journal of Experimental Medicine 206 5: 981–89. https://doi.org/10.1084/jem.20090528.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 15: 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 7418: 116–20. https://doi.org/10.1038/nature11378.
Schneider, Markus, Stefanie Schneider, Reina Zühlke-Jenisch, Wolfram Klapper, Christer Sundström, Sylvia Hartmann, Martin-Leo Hansmann, Reiner Siebert, Ralf Küppers, and Maciej Giefing. 2015. “Alterations of the CD58 Gene in Classical Hodgkin Lymphoma.” Genes, Chromosomes & Cancer 54 10: 638–45. https://doi.org/10.1002/gcc.22276.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/CD95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 5: 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF V600E and MAP2K1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 2: 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Spina, Valeria, Hossein Khiabanian, Monica Messina, Sara Monti, Luciano Cascione, Alessio Bruscaggin, Elisa Spaccarotella, et al. 2016. “The Genetics of Nodal Marginal Zone Lymphoma.” Blood 128 10: 1362–73. https://doi.org/10.1182/blood-2016-02-696757.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated BCL2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 1: 229–37.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 8: 904–16. https://doi.org/10.1182/blood.2022016534.
Tiacci, Enrico, Erik Ladewig, Gianluca Schiavoni, Alex Penson, Elisabetta Fortini, Valentina Pettirossi, Yuchun Wang, et al. 2018. “Pervasive Mutations of JAK-STAT Pathway Genes in Classical Hodgkin Lymphoma.” Blood 131 22: 2454–65. https://doi.org/10.1182/blood-2017-11-814913.
Tiacci, Enrico, Vladimir Trifonov, Gianluca Schiavoni, Antony Holmes, Wolfgang Kern, Maria Paola Martelli, Alessandra Pucciarini, et al. 2011. “BRAF Mutations in Hairy-Cell Leukemia.” The New England Journal of Medicine 364 24: 2305–15. https://doi.org/10.1056/NEJMoa1014209.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. “NOTCH2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 7: 1107–9. https://doi.org/10.3324/haematol.11635.
Viganò, Elena, Jay Gunawardana, Anja Mottok, Tessa Van Tol, Katina Mak, Fong Chun Chan, Lauren Chong, et al. 2018. “Somatic IL4R Mutations in Primary Mediastinal Large B-cell Lymphoma Lead to Constitutive JAK-STAT Signaling Activation.” Blood 131 18: 2036–46. https://doi.org/10.1182/blood-2017-09-808907.
Weniger, M. A., I. Melzner, C. K. Menz, S. Wegener, A. J. Bucur, K. Dorsch, T. Mattfeldt, T. F. E. Barth, and P. Möller. 2006. “Mutations of the Tumor Suppressor Gene SOCS-1 in Classical Hodgkin Lymphoma Are Frequent and Associated with Nuclear Phospho-STAT5 Accumulation.” Oncogene 25 18: 2679–84. https://doi.org/10.1038/sj.onc.1209151.
Wienand, Kirsty, Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, David Wu, Jaegil Kim, Atanas Kamburov, et al. 2019. “Genomic Analyses of Flow-Sorted Hodgkin Reed-Sternberg Cells Reveal Complementary Mechanisms of Immune Evasion.” Blood Advances 3 23: 4065–80. https://doi.org/10.1182/bloodadvances.2019001012.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 3: 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent CARD11 Mutations.” Oncotarget 7 25: 38180–90. https://doi.org/10.18632/oncotarget.9500.
Yan, Qingguo, Yuanxue Huang, A. James Watkins, Sylvia Kocialkowski, Naiyan Zeng, Rifat A. Hamoudi, Peter G. Isaacson, Laurence de Leval, Andrew Wotherspoon, and Ming-Qing Du. 2012. “BCR and TLR Signaling Pathways Are Recurrently Targeted by Genetic Changes in Splenic Marginal Zone Lymphomas.” Haematologica 97 4: 595–98. https://doi.org/10.3324/haematol.2011.054080.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating STAT6 Mutations in Follicular Lymphoma.” Blood 125 4: 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” January.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 19: 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent FOXO1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 14: 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

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