Origins of DLBCL genes

Tier 1 DLBCL genes

126 total

Gene	Summary	First DLBCL study	Other entities	QC result
ACTB	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{1,wienandGenomicAnalysesFlowsorted2019b?}
ACTG1	Tier 1 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al	^{2,spinaGeneticsNodalMarginal2016b?}
ARID1A	Tier 1 GE³, FE⁴, aSHM	Zhang et al	^{5,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c?,wienandGenomicAnalysesFlowsorted2019b?}
ATM	Tier 1 GE⁶, aSHM	Reddy et al	^7,8
B2M	Tier 1 GE⁹, FE^{challa-malladiCombinedGeneticInactivationa?}, aSHM	Morin et al	^{10,reichelFlowSortingExome2015a?}
BCL10	Tier 1 GE⁹, FE¹¹, aSHM	Morin et al	^{russler-germainMutationsAssociatedProgression2023b?,spinaGeneticsNodalMarginal2016b?}
BCL2	Tier 1 GE¹², FE¹³, aSHM	Tanaka et al	^{9,burkhardtClinicalRelevanceMolecular2022b?,sarkozyMutationalLandscapeGray2021a?}
BCL6	Tier 1 GE⁹, FE¹³, aSHM	Morin et al	^1,5
BCL7A	Tier 1 GE⁹, FE^{balinas-gaviraFrequentMutationsAminoterminal2020b?}, aSHM	Morin et al	^{14,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?}
BIRC6	Tier 1 GE⁶, aSHM	Reddy et al	^{sarkozyMutationalLandscapeGray2021a?}
BRAF	Tier 1 GE^{tiacciBRAFMutationsHairycell2011a?}, aSHM	Tiacci et al	⁵
BTG1	Tier 1 GE⁹, FE^{mlynarczykBTG1MutationYields2023b?}, aSHM	Morin et al	^{1,burkhardtClinicalRelevanceMolecular2022b?,sarkozyMutationalLandscapeGray2021a?}
BTG2	Tier 1 GE⁹, CE¹⁵, aSHM	Morin et al	^1,5
BTK	Tier 1 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al	^{krysiakRecurrentSomaticMutations2017b?}
CARD11	Tier 1 GE¹⁶, FE¹⁶, CE^{zhaoExpressionPrognosticValue2016?}, aSHM	Lenz et al	^{9,17,yanBCRTLRSignaling2012a?}
CCND3	Tier 1 GE⁹, FE¹⁸, aSHM	Morin et al	^{2,19,richterRecurrentMutationID32012a?}
CD58	Tier 1 GE⁹, FE^{challa-malladiCombinedGeneticInactivationa?}, aSHM	Morin et al	^{schneiderAlterationsCD58Gene2015a?}
CD70	Tier 1 GE⁹, aSHM	Morin et al	^{russler-germainMutationsAssociatedProgression2023b?}
CD79B	Tier 1 GE⁹, FE²⁰, aSHM	Morin et al	^1,21
CD83	Tier 1 GE²², aSHM	Morin et al	^{21,dunsCharacterizationDLBCLPMBL2021b?,russler-germainMutationsAssociatedProgression2023b?}
CDKN2A	Tier 1 GE²², CE^{jardinDiffuseLargeBcell2010a?}, aSHM	Morin et al	^{14,spinaGeneticsNodalMarginal2016b?}
CIITA	Tier 1 GE⁹, CE²³, aSHM	Morin et al	^{mottokGenomicAlterationsCIITA2015b?}
CREBBP	Tier 1 GE^{pasqualucciInactivatingMutationsAcetyltransferase2011a?}, FE^{pasqualucciInactivatingMutationsAcetyltransferase2011a?}, aSHM	Pasqualucci et al	^{5,24,dunsCharacterizationDLBCLPMBL2021b?}
CXCR4	Tier 1 GE²⁵, aSHM	Khodabakhshi et al	^{21,krysiakRecurrentSomaticMutations2017b?}
CXCR5	Tier 1 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al	^{mottokIntegrativeGenomicAnalysis2019b?}
DDX3X	Tier 1 GE⁶, FE²⁶, CE^{kizhakeyilDDX3XLossAdverse2021?}, aSHM	Reddy et al	^{18,mottokIntegrativeGenomicAnalysis2019b?}
DTX1	Tier 1 GE³, FE²⁷, CE^{merirantaDeltex1MutationsPredict2017b?}, aSHM	Zhang et al	^{5,28,rossiCodingGenomeSplenic2012c?}
DUSP2	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{1,dunsCharacterizationDLBCLPMBL2021b?}
EBF1	Tier 1 GE²⁹, aSHM	Bohle et al	^{30,reichelFlowSortingExome2015a?}
EEF1A1	Tier 1 GE^{hubschmannMutationalMechanismsShaping2021b?}, CE^{gongExpressionClinicalValue2021?}, aSHM	Hubschmann et al	^{reichelFlowSortingExome2015a?}
EP300	Tier 1 GE^{pasqualucciInactivatingMutationsAcetyltransferase2011a?}, FE^{pasqualucciInactivatingMutationsAcetyltransferase2011a?}, aSHM	Pasqualucci et al	^{rossiCodingGenomeSplenic2012c?}
ETS1	Tier 1 GE⁹, aSHM	Morin et al	²¹
ETV6	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, CE²³, aSHM	Lohr et al
EZH2	Tier 1 GE^{morinSomaticMutationsAltering2010a?}, FE^{yapSomaticMutationsEZH22011b?}, aSHM	Morin et al	^{5,mottokIntegrativeGenomicAnalysis2019b?}
FAS	Tier 1 GE³¹, FE³², aSHM	Scholl et al	^{spinaGeneticsNodalMarginal2016b?}
FBXO11	Tier 1 GE^{hubschmannMutationalMechanismsShaping2021b?}, FE³³, aSHM	Hubschmann et al	^{24,richterRecurrentMutationID32012a?}
FBXW7	Tier 1 GE³, FE³⁴, aSHM	Zhang et al
FOXO1	Tier 1 GE⁹, FE³⁵, CE³⁵, aSHM	Morin et al	^{18,dunsCharacterizationDLBCLPMBL2021b?}
GNA13	Tier 1 GE⁹, FE^{muppidiLossSignalingGa132014b?}, aSHM	Morin et al	^{5,reichelFlowSortingExome2015a?}
GNAI2	Tier 1 GE²², aSHM	Morin et al	¹⁴
GRB2	Tier 1 GE³⁶, aSHM	Pasqualucci et al
GRHPR	Tier 1 GE³⁷, aSHM	Arthur et al
HIST1H1B	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{krysiakRecurrentSomaticMutations2017b?,sarkozyMutationalLandscapeGray2021a?}
HIST1H1C	Tier 1 GE⁹, aSHM	Morin et al	²¹
HIST1H1D	Tier 1 GE²², aSHM	Morin et al	^{19,krysiakRecurrentSomaticMutations2017b?}
HIST1H1E	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{14,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?}
HIST1H2AC	Tier 1 GE²², aSHM	Morin et al	^{krysiakRecurrentSomaticMutations2017b?}
HIST1H2AM	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{21,krysiakRecurrentSomaticMutations2017b?}
HIST1H2BC	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{krysiakRecurrentSomaticMutations2017b?,mottokIntegrativeGenomicAnalysis2019b?}
HIST1H2BK	Tier 1 GE³, aSHM	Zhang et al	^{21,rossiCodingGenomeSplenic2012c?}
HIST1H3B	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{reichelFlowSortingExome2015a?}
HIST2H2BE	Tier 1 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
HLA-A	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	²
HLA-B	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{wienandGenomicAnalysesFlowsorted2019b?}
HLA-C	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	²⁸
HLA-DMB	Tier 1 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al
HNRNPU	Tier 1 GE⁶, aSHM	Reddy et al	²¹
HVCN1	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{krysiakRecurrentSomaticMutations2017b?}
IKZF3	Tier 1 GE⁹, aSHM	Morin et al	²¹
IL4R	Tier 1 GE^{dunsCharacterizationDLBCLPMBL2021b?}, FE^{viganoSomaticIL4RMutations2018b?}, aSHM	Duns et al	^{viganoSomaticIL4RMutations2018b?}
IRF4	Tier 1 GE⁹, aSHM	Morin et al	^{1,mottokIntegrativeGenomicAnalysis2019b?}
IRF8	Tier 1 GE⁹, FE³⁸, aSHM	Morin et al	^{21,mottokIntegrativeGenomicAnalysis2019b?}
ITPKB	Tier 1 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al	^{1,reichelFlowSortingExome2015a?}
JUNB	Tier 1 GE⁶, aSHM	Reddy et al	^{mottokIntegrativeGenomicAnalysis2019b?}	PASS
KLF2	Tier 1 GE³⁶, aSHM	Pasqualucci et al	^1,2,19
KLHL14	Tier 1 GE³, FE³⁹, CE⁴⁰, aSHM	Zhang et al
KLHL6	Tier 1 GE⁹, FE⁴¹, aSHM	Morin et al	⁴²
KMT2C	Tier 1 GE³, aSHM	Zhang et al	^{43,44,sarkozyMutationalLandscapeGray2021a?}
KMT2D	Tier 1 GE⁹, FE⁴⁵, CE⁴⁶, aSHM	Morin et al	^{2,7,14,rossiCodingGenomeSplenic2012c?}
KRAS	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
LCOR	Tier 1 GE³⁷, aSHM	Arthur et al
LRRN3	Tier 1 GE³, aSHM	Zhang et al	^{sarkozyMutationalLandscapeGray2021a?}
LTB	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^1,2
MEF2B	Tier 1 GE⁹, FE⁴⁷, aSHM	Morin et al	⁷
MEF2C	Tier 1 GE³⁷, FE⁴⁸, aSHM	Arthur et al
MGA	Tier 1 GE⁶, CE²³, aSHM	Reddy et al	¹⁹
MIR142	Tier 1 GE^{kwanhianMicroRNA142Mutated202012b?}, aSHM	Kwanhian et al	¹⁴
MPEG1	Tier 1 GE²², CE²³, aSHM	Morin et al
MS4A1	Tier 1 GE⁴⁶, FE⁴⁶, CE⁴⁶, aSHM	Rushton et al	^{mottokIntegrativeGenomicAnalysis2019b?}
MTOR	Tier 1 GE³, aSHM	Zhang et al	²¹
MYC	Tier 1 GE^{pasqualucciHypermutationMultipleProtooncogenes2001a?}, FE⁴⁹, CE⁵⁰, aSHM	Pasqualucci et al	^{19,51,dunsCharacterizationDLBCLPMBL2021b?}
MYD88	Tier 1 GE^{ngoOncogenicallyActiveMYD882011a?}, FE^{ngoOncogenicallyActiveMYD882011a?}, CE²³, aSHM	Ngo et al	^{1,yanBCRTLRSignaling2012a?}
NFKBIA	Tier 1 GE⁵², aSHM	Thomas et al	^{russler-germainMutationsAssociatedProgression2023b?,wienandGenomicAnalysesFlowsorted2019b?}
NFKBIE	Tier 1 GE⁵³, FE⁵⁴, aSHM	Morin et al	^10,54
NFKBIZ	Tier 1 GE⁵³, FE³⁷, aSHM	Morin et al
NOL9	Tier 1 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al	^{spinaGeneticsNodalMarginal2016b?}
NOTCH1	Tier 1 GE³⁶, CE⁵⁵, aSHM	Pasqualucci et al	^{5,7,rossiCodingGenomeSplenic2012c?}
NOTCH2	Tier 1 GE³, CE^{campos-martinClinicalDiagnosticRelevance2017?}, aSHM	Zhang et al	^{7,rossiCodingGenomeSplenic2012c?}
OSBPL10	Tier 1 GE³, CE^{dobashiTP53OSBPL10Alterations2018b?}, aSHM	Zhang et al
P2RY8	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, FE^{muppidiLossSignalingGa132014b?}, aSHM	Lohr et al	^{1,muppidiLossSignalingGa132014b?}
PIM1	Tier 1 GE^{pasqualucciHypermutationMultipleProtooncogenes2001a?}, CE²³, aSHM	Pasqualucci et al	^{1,burkhardtClinicalRelevanceMolecular2022b?,dunsCharacterizationDLBCLPMBL2021b?}
PIM2	Tier 1 GE³⁷, aSHM	Arthur et al	^{reichelFlowSortingExome2015a?}
POU2AF1	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{krysiakRecurrentSomaticMutations2017b?}
POU2F2	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, FE^{hodsonRegulationNormalBcell2016a?}, aSHM	Lohr et al	^{krysiakRecurrentSomaticMutations2017b?}
PRDM1	Tier 1 GE^{pasqualucciInactivationPRDM1BLIMP12006a?}, FE^{pasqualucciInactivationPRDM1BLIMP12006a?}, aSHM	Pasqualucci et al
PTEN	Tier 1 GE⁶, aSHM	Reddy et al	⁵
RB1	Tier 1 GE²², aSHM	Morin et al	⁴³
RFX7	Tier 1 GE³⁷, aSHM	Arthur et al	¹⁴
RHOA	Tier 1 GE³, FE⁵⁶, aSHM	Zhang et al	^{richterRecurrentMutationID32012a?}
RRAGC	Tier 1 GE^{okosunRecurrentMTORC1activatingRRAGC2016a?}, FE^{ortega-molinaOncogenicRagGTPase2019b?}, aSHM	Okosun et al
S1PR2	Tier 1 GE⁹, FE⁵⁷, aSHM	Morin et al	^{1,muppidiLossSignalingGa132014b?}
SETD1B	Tier 1 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
SF3B1	Tier 1 GE⁶, aSHM	Reddy et al	⁵
SGK1	Tier 1 GE⁹, FE^{hartmannHighlyRecurrentMutations2016b?}, CE²³, aSHM	Morin et al	^{dunsCharacterizationDLBCLPMBL2021b?}
SIN3A	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{14,rossiCodingGenomeSplenic2012c?}
SMARCA4	Tier 1 GE⁶, FE⁵⁸, aSHM	Reddy et al	^{krysiakRecurrentSomaticMutations2017b?,nadeuGenomicEpigenomicInsights2020b?,richterRecurrentMutationID32012a?}
SOCS1	Tier 1 GE⁹, FE^{melznerBiallelicMutationSOCS12005a?}, aSHM	Morin et al	^{1,wenigerMutationsTumorSuppressor2006a?}
SPEN	Tier 1 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, CE²³, aSHM	Albuquerque et al	^{rossiCodingGenomeSplenic2012c?,sarkozyMutationalLandscapeGray2021a?}
STAT3	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, FE^{huNovelMissenseM206K2013b?}, aSHM	Lohr et al
STAT6	Tier 1 GE^{yildizActivatingSTAT6Mutations2015c?}, FE^{yildizActivatingSTAT6Mutations2015c?}, aSHM	Yildiz et al	^{ritzRecurrentMutationsSTAT62009a?}
TAF1	Tier 1 GE²², aSHM	Morin et al	^{spinaGeneticsNodalMarginal2016b?}
TBL1XR1	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, FE^{venturuttiTBL1XR1MutationsDrive2020b?}, aSHM	Lohr et al	^{rossiCodingGenomeSplenic2012c?}
TET2	Tier 1 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al	³⁰
TMEM30A	Tier 1 GE⁹, FE^{ennishiTMEM30ALossoffunctionMutations2020b?}, CE^{ennishiTMEM30ALossoffunctionMutations2020b?}, aSHM	Morin et al
TMSB4X	Tier 1 GE³, aSHM	Zhang et al
TNFAIP3	Tier 1 GE^{compagnoMutationsMultipleGenes2009a?}, FE^{compagnoMutationsMultipleGenes2009a?}, aSHM	Compagno et al	^{rossiAlterationBIRC3Multiple2011a?,schmitzTNFAIP3A20Tumor2009a?}
TNFRSF14	Tier 1 GE⁹, CE²³, aSHM	Morin et al	^{cheungAcquiredTNFRSF14Mutations2010a?,spinaGeneticsNodalMarginal2016b?}
TOX	Tier 1 GE⁶, aSHM	Reddy et al
TP53	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, FE^{rowhTp53DeletionLineage2011?}, aSHM	Lohr et al	^{7,9,59,rossiCodingGenomeSplenic2012c?,tiacciPervasiveMutationsJAKSTAT2018b?}
UBE2A	Tier 1 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	^{reichelFlowSortingExome2015a?}
WEE1	Tier 1 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al	^{reichelFlowSortingExome2015a?}
XPO1	Tier 1 GE⁶⁰, aSHM	Mareschal et al	^{jardinRecurrentMutationsExportin2016a?}
ZC3H12A	Tier 1 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al
ZFP36L1	Tier 1 GE⁹, aSHM	Morin et al	^{21,reichelFlowSortingExome2015a?}
ZNF292	Tier 1 GE⁶, aSHM	Reddy et al
ZNF608	Tier 1 GE²², aSHM	Morin et al	^{krysiakRecurrentSomaticMutations2017b?}

Tier 2 DLBCL genes

179 total

Gene	Summary	First DLBCL study	Other entities	QC result
ABI3BP	Tier 2 GE²², aSHM	Morin et al		PASS
ADAMTS1	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
AICDA	Tier 2 GE³⁷, aSHM	Arthur et al
ANKRD12	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
ANKRD17	Tier 2 GE³, aSHM	Zhang et al
ARID5B	Tier 2 GE⁶, aSHM	Reddy et al	²⁸	PASS
ASXL3	Tier 2 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
ATR	Tier 2 GE⁶, aSHM	Reddy et al		PASS
BCL11A	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al
BCOR	Tier 2 GE, aSHM		^{19,nadeuGenomicEpigenomicInsights2020b?}
BCR	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
BIRC3	Tier 2 GE³⁷, aSHM	Arthur et al	^{7,dunsCharacterizationDLBCLPMBL2021b?,rossiAlterationBIRC3Multiple2011a?}
BLK	Tier 2 GE, aSHM
BRINP3	Tier 2 GE⁶, aSHM	Reddy et al		PASS
BTBD3	Tier 2 GE³, aSHM	Zhang et al
CADPS2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
CASP8	Tier 2 GE⁶, FE⁶¹, aSHM	Reddy et al
CD22	Tier 2 GE⁶, aSHM	Reddy et al		PASS
CD274	Tier 2 GE⁹, aSHM	Morin et al
CD36	Tier 2 GE³⁶, aSHM	Pasqualucci et al
CD44	Tier 2 GE³⁷, aSHM	Arthur et al
CD74	Tier 2 GE³⁷, aSHM	Arthur et al
CDH9	Tier 2 GE²², aSHM	Morin et al		PASS
CEP164	Tier 2 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
CNOT2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
CNTNAP5	Tier 2 GE²², aSHM	Morin et al		PASS
COQ7	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
CPS1	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
CRIP1	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
DAZAP1	Tier 2 GE¹⁰, aSHM	Pararajalingam et al
DDX10	Tier 2 GE³, aSHM	Zhang et al
DHX16	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
DNAH5	Tier 2 GE²², aSHM	Morin et al	¹⁹	PASS
DNM2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
DNMT3B	Tier 2 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
DOCK1	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
DSG4	Tier 2 GE²², aSHM	Morin et al		PASS
EIF2AK3	Tier 2 GE, aSHM
ERAP2	Tier 2 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
EZR	Tier 2 GE, aSHM		²
FAM102A	Tier 2 GE, aSHM
FANK1	Tier 2 GE, aSHM
FAT2	Tier 2 GE⁹, aSHM	Morin et al
FAT4	Tier 2 GE²², aSHM	Morin et al	^24,43	PASS
FCRL3	Tier 2 GE, aSHM
FNBP1	Tier 2 GE, aSHM
FOXC1	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
FOXP1	Tier 2 GE⁶, aSHM	Reddy et al		PASS
FUBP1	Tier 2 GE⁶, aSHM	Reddy et al		PASS
GABRA1	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
GABRA2	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al
GOLGA5	Tier 2 GE⁶, aSHM	Reddy et al		PASS
GPC5	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
GSG2	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
H1FOO	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
HDAC7	Tier 2 GE²², aSHM	Morin et al		PASS
HIST1H2AG	Tier 2 GE²², aSHM	Morin et al	^{21,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c?}	PASS
HIST1H2AL	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
HIST1H2BO	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
HLA-DMA	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al
HNF1B	Tier 2 GE³⁶, aSHM	Pasqualucci et al
HNRNPD	Tier 2 GE⁶, aSHM	Reddy et al
HNRNPH1	Tier 2 GE¹⁰, FE¹⁰, CE¹⁰, aSHM	Pararajalingam et al
ID3	Tier 2 GE¹⁸, FE^{richterRecurrentMutationID32012a?}, aSHM	Schmitz et al	^{richterRecurrentMutationID32012a?,spinaGeneticsNodalMarginal2016b?}
IFNGR1	Tier 2 GE²², aSHM	Morin et al		PASS
IGLL5	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	^{2,21,russler-germainMutationsAssociatedProgression2023b?}
IKBKB	Tier 2 GE⁶, aSHM	Reddy et al	^{rossiAlterationBIRC3Multiple2011a?,wienandGenomicAnalysesFlowsorted2019b?}	PASS
IKBKE	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
IL16	Tier 2 GE⁶, aSHM	Reddy et al
IL6	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
INO80	Tier 2 GE³, aSHM	Zhang et al
IRF1	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
JAK1	Tier 2 GE³, aSHM	Zhang et al	^{mottokIntegrativeGenomicAnalysis2019b?}
JAK3	Tier 2 GE³, aSHM	Zhang et al
KCMF1	Tier 2 GE⁶, aSHM	Reddy et al		PASS
KLHL21	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
KRTAP5-5	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
LAMA5	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
LAPTM5	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
LPP	Tier 2 GE³⁷, aSHM	Arthur et al
LRP12	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
LYN	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
MAGT1	Tier 2 GE⁶, aSHM	Reddy et al		PASS
MALAT1	Tier 2 GE³⁷, aSHM	Arthur et al
MAP2K1	Tier 2 GE⁶², aSHM	Shin et al	^{louissaintPediatrictypeNodalFollicular2016a?}
MCL1	Tier 2 GE⁶, aSHM	Reddy et al	^{21,dunsCharacterizationDLBCLPMBL2021b?}	PASS
MECOM	Tier 2 GE⁶, aSHM	Reddy et al		PASS
MET	Tier 2 GE⁶, aSHM	Reddy et al		PASS
MIR155HG	Tier 2 GE, aSHM
MPDZ	Tier 2 GE²², aSHM	Morin et al	^{reichelFlowSortingExome2015a?}	PASS
MSH6	Tier 2 GE⁶, aSHM	Reddy et al		PASS
MYBPC2	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
MYO1E	Tier 2 GE, aSHM
MYOM2	Tier 2 GE³⁶, aSHM	Pasqualucci et al
NAV1	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al
NCOA3	Tier 2 GE, aSHM
NCOR2	Tier 2 GE, aSHM		^{18,sarkozyMutationalLandscapeGray2021a?,spinaGeneticsNodalMarginal2016b?}
NEAT1	Tier 2 GE³⁷, aSHM	Arthur et al
NF1	Tier 2 GE³, aSHM	Zhang et al
NFKB1	Tier 2 GE, aSHM
NLRC5	Tier 2 GE, aSHM
NLRP5	Tier 2 GE²², aSHM	Morin et al		PASS
ODZ3	Tier 2 GE²², aSHM	Morin et al		PASS
OR6K3	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
P2RX5	Tier 2 GE²², aSHM	Morin et al		PASS
PAPOLG	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
PASD1	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
PASK	Tier 2 GE²², aSHM	Morin et al		PASS
PAX5	Tier 2 GE^{pasqualucciHypermutationMultipleProtooncogenes2001a?}, aSHM	Pasqualucci et al
PCBP1	Tier 2 GE, aSHM		¹⁸
PCDHB11	Tier 2 GE²², aSHM	Morin et al		PASS
PCDHB6	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
PCLO	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
PDGFC	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
PDS5B	Tier 2 GE²², aSHM	Morin et al	^{hubschmannMutationalMechanismsShaping2021b?}	PASS
PIK3CD	Tier 2 GE³, aSHM	Zhang et al
PIK3R1	Tier 2 GE³, aSHM	Zhang et al	²¹
PNPO	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
PPP1R9B	Tier 2 GE, aSHM
PRKCB	Tier 2 GE²², aSHM	Morin et al		PASS
PRKDC	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al	^{hubschmannMutationalMechanismsShaping2021b?}
PRPS1	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS
PTMA	Tier 2 GE, aSHM
PTPN1	Tier 2 GE, aSHM		^{gunawardanaRecurrentSomaticMutations2014c?}
PTPN6	Tier 2 GE⁶, aSHM	Reddy et al		PASS
PTPRD	Tier 2 GE, aSHM		^{1,spinaGeneticsNodalMarginal2016b?}
RAC2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
RAPGEF1	Tier 2 GE⁹, aSHM	Morin et al
RCC	Tier 2 GE, aSHM
RFTN1	Tier 2 GE³⁷, aSHM	Arthur et al	^{dunsCharacterizationDLBCLPMBL2021b?}
RFXAP	Tier 2 GE, aSHM
RHEX	Tier 2 GE, aSHM
RHOH	Tier 2 GE^{pasqualucciHypermutationMultipleProtooncogenes2001a?}, aSHM	Pasqualucci et al
RUBCNL	Tier 2 GE, aSHM
S1PR1	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al	¹⁰
SAMD9L	Tier 2 GE²², aSHM	Morin et al		PASS
SEL1L3	Tier 2 GE, aSHM
SEPTIN9	Tier 2 GE, aSHM
SERPINA9	Tier 2 GE³⁷, aSHM	Arthur et al
SETD2	Tier 2 GE³, aSHM	Zhang et al
SETD5	Tier 2 GE⁶, aSHM	Reddy et al	^{tiacciPervasiveMutationsJAKSTAT2018b?}	PASS
SIAH2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al	^{reichelFlowSortingExome2015a?}	PASS
SLC34A2	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
SLC38A8	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
SLITRK6	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
SMEK1	Tier 2 GE³, aSHM	Zhang et al
SRPX	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
SRRM2	Tier 2 GE²², aSHM	Morin et al	^{russler-germainMutationsAssociatedProgression2023b?}	PASS
ST6GAL1	Tier 2 GE³⁷, aSHM	Arthur et al
STAT5B	Tier 2 GE³, aSHM	Zhang et al	^{tiacciPervasiveMutationsJAKSTAT2018b?}
SYN2	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
SYPL1	Tier 2 GE²², aSHM	Morin et al		PASS
TAP1	Tier 2 GE^{schmitzGeneticsPathogenesisDiffuse2018a?}, aSHM	Schmitz et al
TBC1D4	Tier 2 GE³⁷, aSHM	Arthur et al
TCL1A	Tier 2 GE⁶, aSHM	Reddy et al	¹⁴
TGFBR2	Tier 2 GE⁶, aSHM	Reddy et al		PASS
TIPARP	Tier 2 GE⁶, aSHM	Reddy et al		PASS
TLR2	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al	⁷	PASS
TMSL3	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
TNF	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
TRAF3	Tier 2 GE³⁶, aSHM	Pasqualucci et al	^{ottoGeneticLesionsTRAF32012a?,rossiAlterationBIRC3Multiple2011a?}
TRAF6	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
TRIP12	Tier 2 GE, aSHM
UBE2J1	Tier 2 GE, aSHM
UBR5	Tier 2 GE³, aSHM	Zhang et al	¹⁰
UHRF1BP1	Tier 2 GE^{albuquerqueEnhancingKnowledgeDiscovery2017a?}, aSHM	Albuquerque et al
UNC5B	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		PASS
UNC5C	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
UNC5D	Tier 2 GE^{lohrDiscoveryPrioritizationSomatic2012a?}, aSHM	Lohr et al
USP7	Tier 2 GE³⁷, aSHM	Arthur et al	¹⁴
WDFY3	Tier 2 GE²², aSHM	Morin et al		PASS
WNK1	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al	^19,30	PASS
XBP1	Tier 2 GE, aSHM
YY1	Tier 2 GE⁶, aSHM	Reddy et al		PASS
ZCCHC7	Tier 2 GE³⁷, aSHM	Arthur et al
ZEB2	Tier 2 GE³, aSHM	Zhang et al
ZFX	Tier 2 GE⁶, aSHM	Reddy et al		PASS
ZNF217	Tier 2 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al	^{reichelFlowSortingExome2015a?}	PASS
ZNF423	Tier 2 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		PASS

Tier 3 DLBCL genes

386 total

Gene	Summary	First DLBCL study	Other entities	QC result
ABCA3	Tier 3 GE³, aSHM	Zhang et al	⁷
ABCA4	Tier 3 GE³, aSHM	Zhang et al
ABCB1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ACE	Tier 3 GE³, aSHM	Zhang et al	⁵
ACSM3	Tier 3 GE³, aSHM	Zhang et al
ACSS2	Tier 3 GE³, aSHM	Zhang et al
ACSS3	Tier 3 GE³, aSHM	Zhang et al
ACTN1	Tier 3 GE³, aSHM	Zhang et al
ADAM2	Tier 3 GE³, aSHM	Zhang et al
ADAMTS15	Tier 3 GE³, aSHM	Zhang et al
ADH7	Tier 3 GE³, aSHM	Zhang et al
AFAP1L2	Tier 3 GE³, aSHM	Zhang et al
AGA	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
AHR	Tier 3 GE³, aSHM	Zhang et al
AKAP9	Tier 3 GE³, aSHM	Zhang et al
ALAS1	Tier 3 GE³, aSHM	Zhang et al
ALDH1L2	Tier 3 GE³, aSHM	Zhang et al
AMAC1	Tier 3 GE³, aSHM	Zhang et al
AMIGO3	Tier 3 GE³, aSHM	Zhang et al
AMPH	Tier 3 GE³, aSHM	Zhang et al
ANK2	Tier 3 GE³, aSHM	Zhang et al	⁴³
ANKRD44	Tier 3 GE³, aSHM	Zhang et al
ANTXR1	Tier 3 GE³, aSHM	Zhang et al
AP1G2	Tier 3 GE³, aSHM	Zhang et al
APBB1	Tier 3 GE³, aSHM	Zhang et al
APC	Tier 3 GE³, aSHM	Zhang et al
APMAP	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
APOA5	Tier 3 GE³, aSHM	Zhang et al
APP	Tier 3 GE³, aSHM	Zhang et al
ARID1B	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
ATIC	Tier 3 GE³, aSHM	Zhang et al
ATP10A	Tier 3 GE³, aSHM	Zhang et al
ATP1A2	Tier 3 GE³, aSHM	Zhang et al
ATP2A3	Tier 3 GE³, aSHM	Zhang et al
ATP6V0A1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
B4GALNT2	Tier 3 GE³, aSHM	Zhang et al
BAZ1A	Tier 3 GE³, aSHM	Zhang et al
BCAT2	Tier 3 GE³, aSHM	Zhang et al
BLM	Tier 3 GE³, aSHM	Zhang et al
BMPR1A	Tier 3 GE³, aSHM	Zhang et al
BRCA1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
BRCA2	Tier 3 GE³, aSHM	Zhang et al
BRD4	Tier 3 GE³, aSHM	Zhang et al	⁵
BSCL2	Tier 3 GE³, aSHM	Zhang et al
BTAF1	Tier 3 GE³, aSHM	Zhang et al
C9	Tier 3 GE³, aSHM	Zhang et al
CAD	Tier 3 GE³, aSHM	Zhang et al	⁵
CAPN5	Tier 3 GE³, aSHM	Zhang et al
CAPN7	Tier 3 GE³, aSHM	Zhang et al
CBLB	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
CBX3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CCDC132	Tier 3 GE³, aSHM	Zhang et al
CCDC46	Tier 3 GE³, aSHM	Zhang et al
CCDC97	Tier 3 GE³, aSHM	Zhang et al
CCL4	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
CCNF	Tier 3 GE³, aSHM	Zhang et al	^{abateDistinctViralMutational2015a?}
CDC123	Tier 3 GE³, aSHM	Zhang et al
CDC73	Tier 3 GE⁶, aSHM	Reddy et al	⁵	FAIL
CDH10	Tier 3 GE³, aSHM	Zhang et al
CDH7	Tier 3 GE³, aSHM	Zhang et al
CDH8	Tier 3 GE⁶, aSHM	Reddy et al	⁴³	FAIL
CDK3	Tier 3 GE³, aSHM	Zhang et al
CDKN1A	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CECR1	Tier 3 GE³, aSHM	Zhang et al
CELSR2	Tier 3 GE³, aSHM	Zhang et al
CGN	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CHD1	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
CHD3	Tier 3 GE³, aSHM	Zhang et al
CHEK2	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CHRM5	Tier 3 GE³, aSHM	Zhang et al
CHST2	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
CIC	Tier 3 GE³, aSHM	Zhang et al
CNGA4	Tier 3 GE³, aSHM	Zhang et al
CNOT6	Tier 3 GE³, aSHM	Zhang et al
CNP	Tier 3 GE³, aSHM	Zhang et al
CNTN6	Tier 3 GE³, aSHM	Zhang et al
COL5A2	Tier 3 GE³, aSHM	Zhang et al
CORO2A	Tier 3 GE³, aSHM	Zhang et al
CORO7	Tier 3 GE³, aSHM	Zhang et al
CRELD2	Tier 3 GE³, aSHM	Zhang et al
CRTC3	Tier 3 GE³, aSHM	Zhang et al
CSNK1A1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CSNK2A1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
CST7	Tier 3 GE³, aSHM	Zhang et al
CTNNA3	Tier 3 GE³, aSHM	Zhang et al
CYP24A1	Tier 3 GE³, aSHM	Zhang et al
CYP2C18	Tier 3 GE³, aSHM	Zhang et al
CYYR1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
DCAF6	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
DDB1	Tier 3 GE³, aSHM	Zhang et al
DGCR8	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
DHX33	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
DIAPH3	Tier 3 GE³, aSHM	Zhang et al
DICER1	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
DIP2B	Tier 3 GE³, aSHM	Zhang et al
DLGAP1	Tier 3 GE³, aSHM	Zhang et al	⁵
DMXL1	Tier 3 GE³, aSHM	Zhang et al
DNMT3A	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
DOCK2	Tier 3 GE³, aSHM	Zhang et al
DOCK5	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
DOLK	Tier 3 GE³, aSHM	Zhang et al
DSC2	Tier 3 GE³, aSHM	Zhang et al
DSCAML1	Tier 3 GE³, aSHM	Zhang et al
DSG2	Tier 3 GE³, aSHM	Zhang et al
DSP	Tier 3 GE³, aSHM	Zhang et al
DUOXA2	Tier 3 GE³, aSHM	Zhang et al
DUPD1	Tier 3 GE³, aSHM	Zhang et al
DYNC1H1	Tier 3 GE³, aSHM	Zhang et al
DYNC1I1	Tier 3 GE³, aSHM	Zhang et al
ECGF1	Tier 3 GE³, aSHM	Zhang et al
ECT2L	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
EGFR	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
EPHA3	Tier 3 GE³, aSHM	Zhang et al
EPHA5	Tier 3 GE³, aSHM	Zhang et al
EPHA7	Tier 3 GE³, aSHM	Zhang et al	^{mottokIntegrativeGenomicAnalysis2019b?}
ERBB3	Tier 3 GE³, aSHM	Zhang et al
ERN2	Tier 3 GE³, aSHM	Zhang et al
ETNPPL	Tier 3 GE³, aSHM	Zhang et al
EXTL3	Tier 3 GE³, aSHM	Zhang et al
FAIM	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
FAM161A	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
FAM38B	Tier 3 GE²², aSHM	Morin et al		FAIL
FAM62C	Tier 3 GE³, aSHM	Zhang et al
FANCD2	Tier 3 GE³, aSHM	Zhang et al
FGD3	Tier 3 GE³, aSHM	Zhang et al
FGFR1	Tier 3 GE³, aSHM	Zhang et al
FIGN	Tier 3 GE³, aSHM	Zhang et al
FLNA	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
FLNC	Tier 3 GE³, aSHM	Zhang et al
FLT1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
FMO2	Tier 3 GE³, aSHM	Zhang et al
FN1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
FNDC1	Tier 3 GE²², aSHM	Morin et al		FAIL
FRMPD1	Tier 3 GE³, aSHM	Zhang et al
FUT5	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
FZD1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
GABRG1	Tier 3 GE³, aSHM	Zhang et al
GAK	Tier 3 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		FAIL
GATA2	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
GATA3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
GCN1L1	Tier 3 GE³, aSHM	Zhang et al
GJA8	Tier 3 GE³, aSHM	Zhang et al
GJB4	Tier 3 GE³, aSHM	Zhang et al
GNAS	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
GOPC	Tier 3 GE³, aSHM	Zhang et al
GPD2	Tier 3 GE³, aSHM	Zhang et al
GPR133	Tier 3 GE³, aSHM	Zhang et al
GPR15	Tier 3 GE³, aSHM	Zhang et al
GREM2	Tier 3 GE³, aSHM	Zhang et al
GRIA2	Tier 3 GE³, aSHM	Zhang et al
GRM5	Tier 3 GE³, aSHM	Zhang et al
H6PD	Tier 3 GE³, aSHM	Zhang et al
HACE1	Tier 3 GE³, aSHM	Zhang et al
HCK	Tier 3 GE³, aSHM	Zhang et al
HFE	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
HIPK3	Tier 3 GE³, aSHM	Zhang et al
HIST1H4I	Tier 3 GE³, aSHM	Zhang et al
HK3	Tier 3 GE³, aSHM	Zhang et al
HLA-DQA1	Tier 3 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		FAIL
HLA-DRB1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
HNRNPR	Tier 3 GE³, aSHM	Zhang et al
HRAS	Tier 3 GE⁶, aSHM	Reddy et al	¹⁹	FAIL
HSF2	Tier 3 GE³, aSHM	Zhang et al
IDH1	Tier 3 GE³, aSHM	Zhang et al
IER2	Tier 3 GE²², aSHM	Morin et al		FAIL
IL6ST	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
INSC	Tier 3 GE³, aSHM	Zhang et al
INTS6	Tier 3 GE³, aSHM	Zhang et al
IQGAP1	Tier 3 GE³, aSHM	Zhang et al
IQUB	Tier 3 GE³, aSHM	Zhang et al
ITGA2	Tier 3 GE³, aSHM	Zhang et al
ITGA8	Tier 3 GE³, aSHM	Zhang et al
ITGB3	Tier 3 GE³, aSHM	Zhang et al
ITGB4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ITPR1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
JAG1	Tier 3 GE³, aSHM	Zhang et al
JAKMIP2	Tier 3 GE³, aSHM	Zhang et al
KCNA3	Tier 3 GE³, aSHM	Zhang et al
KCNAB3	Tier 3 GE³, aSHM	Zhang et al
KCNJ6	Tier 3 GE³, aSHM	Zhang et al
KCNT2	Tier 3 GE³, aSHM	Zhang et al
KDR	Tier 3 GE³, aSHM	Zhang et al
KIF21B	Tier 3 GE³, aSHM	Zhang et al
KIT	Tier 3 GE³, aSHM	Zhang et al
KITLG	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
KLB	Tier 3 GE³, aSHM	Zhang et al
KLC3	Tier 3 GE³, aSHM	Zhang et al
KLF4	Tier 3 GE³, aSHM	Zhang et al
KLRC4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
KRT6A	Tier 3 GE³, aSHM	Zhang et al
LEPR	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
LEPREL1	Tier 3 GE³, aSHM	Zhang et al
LIFR	Tier 3 GE³, aSHM	Zhang et al
LILRA2	Tier 3 GE³, aSHM	Zhang et al
LIN54	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
LIN7C	Tier 3 GE³, aSHM	Zhang et al
LPHN2	Tier 3 GE³, aSHM	Zhang et al
LRAP	Tier 3 GE³, aSHM	Zhang et al
LRIG3	Tier 3 GE³, aSHM	Zhang et al
LRP1	Tier 3 GE³, aSHM	Zhang et al
LRP10	Tier 3 GE³, aSHM	Zhang et al
LRP1B	Tier 3 GE³, aSHM	Zhang et al	^{spinaGeneticsNodalMarginal2016b?}
LRP3	Tier 3 GE³, aSHM	Zhang et al
LYST	Tier 3 GE³, aSHM	Zhang et al
MAP2K3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
MAP4K4	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
MARCHF7	Tier 3 GE³, aSHM	Zhang et al
MARK1	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
MBL2	Tier 3 GE³, aSHM	Zhang et al
MCM8	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
MED13L	Tier 3 GE³, aSHM	Zhang et al
MIB1	Tier 3 GE³, aSHM	Zhang et al
MLH1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
MMEL1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
MN1	Tier 3 GE³, aSHM	Zhang et al
MORC2	Tier 3 GE³, aSHM	Zhang et al
MPL	Tier 3 GE³, aSHM	Zhang et al
MSH2	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
MSN	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
MTMR3	Tier 3 GE³, aSHM	Zhang et al
MYB	Tier 3 GE⁶, aSHM	Reddy et al	²	FAIL
MYL7	Tier 3 GE³, aSHM	Zhang et al
MYO5C	Tier 3 GE³, aSHM	Zhang et al
MYRIP	Tier 3 GE³, aSHM	Zhang et al
NANOG	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
NCOR1	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
NDUFS1	Tier 3 GE³, aSHM	Zhang et al
NELL2	Tier 3 GE³, aSHM	Zhang et al
NFIB	Tier 3 GE³, aSHM	Zhang et al
NFKB2	Tier 3 GE⁶, aSHM	Reddy et al	^{mottokIntegrativeGenomicAnalysis2019b?}	FAIL
NFX1	Tier 3 GE³, aSHM	Zhang et al
NGFR	Tier 3 GE³, aSHM	Zhang et al
NIPBL	Tier 3 GE³, aSHM	Zhang et al
NLGN2	Tier 3 GE³, aSHM	Zhang et al
NLRP7	Tier 3 GE³, aSHM	Zhang et al
NLRP8	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
NOTCH3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
NPHP1	Tier 3 GE³, aSHM	Zhang et al
NPY2R	Tier 3 GE³, aSHM	Zhang et al
NR2F2	Tier 3 GE^{hubschmannMutationalMechanismsShaping2021b?}, aSHM	Hubschmann et al		FAIL
NRXN2	Tier 3 GE³, aSHM	Zhang et al	⁵
NSD1	Tier 3 GE³, aSHM	Zhang et al
NSD2	Tier 3 GE³, aSHM	Zhang et al	⁷
NUP153	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ONECUT1	Tier 3 GE³, aSHM	Zhang et al
PABPC1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PADI1	Tier 3 GE³, aSHM	Zhang et al
PAPPA2	Tier 3 GE³, aSHM	Zhang et al
PBX1	Tier 3 GE³, aSHM	Zhang et al
PCCB	Tier 3 GE³, aSHM	Zhang et al
PCDE1C	Tier 3 GE³, aSHM	Zhang et al
PCDH7	Tier 3 GE³, aSHM	Zhang et al
PCDHB1	Tier 3 GE³, aSHM	Zhang et al
PCDHB15	Tier 3 GE³, aSHM	Zhang et al
PCDHB3	Tier 3 GE³, aSHM	Zhang et al
PCDHB5	Tier 3 GE³, aSHM	Zhang et al
PCDHGA2	Tier 3 GE³, aSHM	Zhang et al
PDE1C	Tier 3 GE³, aSHM	Zhang et al
PDE4DIP	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
PDGFRA	Tier 3 GE³, aSHM	Zhang et al
PDGFRB	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PDIA2	Tier 3 GE³, aSHM	Zhang et al
PDZRN3	Tier 3 GE³, aSHM	Zhang et al	²¹
PDZRN4	Tier 3 GE³, aSHM	Zhang et al
PFN1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PGR	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PHF6	Tier 3 GE⁶, aSHM	Reddy et al	³⁰	FAIL
PKD1	Tier 3 GE²², aSHM	Morin et al		FAIL
PLA2G4B	Tier 3 GE³, aSHM	Zhang et al
PLCB4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PLCG2	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al	²¹
PLEKHA7	Tier 3 GE³, aSHM	Zhang et al
PNLIPRP1	Tier 3 GE³, aSHM	Zhang et al
PNPT1	Tier 3 GE³, aSHM	Zhang et al
POGZ	Tier 3 GE²², aSHM	Morin et al		FAIL
POLD3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
POLE	Tier 3 GE³, aSHM	Zhang et al
POLQ	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PPARGC1A	Tier 3 GE³, aSHM	Zhang et al
PPP2R2B	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PPWD1	Tier 3 GE³, aSHM	Zhang et al
PRDM16	Tier 3 GE³, aSHM	Zhang et al
PRKCB1	Tier 3 GE³, aSHM	Zhang et al
PRKCQ	Tier 3 GE³, aSHM	Zhang et al
PROS1	Tier 3 GE³, aSHM	Zhang et al
PRSS7	Tier 3 GE³, aSHM	Zhang et al
PTCH1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
PTPN14	Tier 3 GE³, aSHM	Zhang et al
PTPN23	Tier 3 GE²², aSHM	Morin et al		FAIL
PTPRF	Tier 3 GE³, aSHM	Zhang et al
PTPRK	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
PTPRT	Tier 3 GE³, aSHM	Zhang et al
PXK	Tier 3 GE³, aSHM	Zhang et al
RAB3GAP1	Tier 3 GE³, aSHM	Zhang et al
RAD9A	Tier 3 GE^{chapuyMolecularSubtypesDiffuse2018b?}, aSHM	Chapuy et al		FAIL
RAF1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al	¹⁹
RAPGEF2	Tier 3 GE³, aSHM	Zhang et al
RAPGEF3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
RARA	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
RBM15B	Tier 3 GE³, aSHM	Zhang et al
RECQL4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
RELN	Tier 3 GE³, aSHM	Zhang et al	^{sarkozyMutationalLandscapeGray2021a?}
RET	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al	⁵
RFC1	Tier 3 GE³, aSHM	Zhang et al
RGS1	Tier 3 GE³, aSHM	Zhang et al	^{mottokIntegrativeGenomicAnalysis2019b?}
RHPN2	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
RIF1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
RIMS4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ROR2	Tier 3 GE³, aSHM	Zhang et al
RPTOR	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
RSL1D1	Tier 3 GE³, aSHM	Zhang et al
RUNDC1	Tier 3 GE³, aSHM	Zhang et al
RUNX1	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
RYR1	Tier 3 GE³, aSHM	Zhang et al
SAPS3	Tier 3 GE³, aSHM	Zhang et al
SARM1	Tier 3 GE²², aSHM	Morin et al		FAIL
SCYL1	Tier 3 GE³, aSHM	Zhang et al
SEMA3A	Tier 3 GE³, aSHM	Zhang et al
SEMA3D	Tier 3 GE³, aSHM	Zhang et al
SEMA5A	Tier 3 GE³, aSHM	Zhang et al
SERINC2	Tier 3 GE³, aSHM	Zhang et al
SH3PXD2B	Tier 3 GE³, aSHM	Zhang et al
SHMT2	Tier 3 GE³, aSHM	Zhang et al
SIGLEC10	Tier 3 GE³, aSHM	Zhang et al
SLC16A7	Tier 3 GE³, aSHM	Zhang et al
SLC16A8	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
SLC4A8	Tier 3 GE³, aSHM	Zhang et al
SLC5A1	Tier 3 GE³, aSHM	Zhang et al
SLC9A5	Tier 3 GE³, aSHM	Zhang et al
SMO	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
SOS2	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
SOX6	Tier 3 GE³, aSHM	Zhang et al
SPEG	Tier 3 GE³, aSHM	Zhang et al
SPTBN1	Tier 3 GE³, aSHM	Zhang et al
ST8SIA3	Tier 3 GE³, aSHM	Zhang et al
SULF2	Tier 3 GE³, aSHM	Zhang et al
SYK	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
TAF1L	Tier 3 GE³, aSHM	Zhang et al
TAF4B	Tier 3 GE³, aSHM	Zhang et al
TECRL	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
THBS4	Tier 3 GE³, aSHM	Zhang et al
TIMM50	Tier 3 GE³, aSHM	Zhang et al
TLN1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
TLN2	Tier 3 GE³, aSHM	Zhang et al
TLR4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
TMC1	Tier 3 GE³, aSHM	Zhang et al
TMEM161A	Tier 3 GE³, aSHM	Zhang et al
TMEM16E	Tier 3 GE³, aSHM	Zhang et al
TMEM63A	Tier 3 GE³, aSHM	Zhang et al
TNPO1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
TPR	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
TPRKB	Tier 3 GE³, aSHM	Zhang et al
TRIM37	Tier 3 GE³, aSHM	Zhang et al
TRIP11	Tier 3 GE³, aSHM	Zhang et al	^{reichelFlowSortingExome2015a?}
TRRAP	Tier 3 GE³, aSHM	Zhang et al	^{rossiCodingGenomeSplenic2012c?}
TSC2	Tier 3 GE³, aSHM	Zhang et al
TSHZ2	Tier 3 GE³, aSHM	Zhang et al
TYRO3	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
UBXN11	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
UBXN2B	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
UHRF1BP1L	Tier 3 GE³, aSHM	Zhang et al
UNC13B	Tier 3 GE³, aSHM	Zhang et al
UQCRC1	Tier 3 GE³, aSHM	Zhang et al
VANGL1	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
VPS13A	Tier 3 GE³, aSHM	Zhang et al
WAC	Tier 3 GE⁶, aSHM	Reddy et al	^{rossiCodingGenomeSplenic2012c?}	FAIL
WDR65	Tier 3 GE³, aSHM	Zhang et al
WDR66	Tier 3 GE³, aSHM	Zhang et al
WDR67	Tier 3 GE³, aSHM	Zhang et al
WIF1	Tier 3 GE³, aSHM	Zhang et al
WNK4	Tier 3 GE³, aSHM	Zhang et al
WT1	Tier 3 GE³, aSHM	Zhang et al
XDH	Tier 3 GE³, aSHM	Zhang et al
ZBTB7A	Tier 3 GE⁶, aSHM	Reddy et al	^{burkhardtClinicalRelevanceMolecular2022b?}	FAIL
ZFAT	Tier 3 GE⁶, aSHM	Reddy et al		FAIL
ZIC4	Tier 3 GE³, aSHM	Zhang et al
ZMYM4	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ZNF354A	Tier 3 GE³, aSHM	Zhang et al
ZNF366	Tier 3 GE³, aSHM	Zhang et al
ZNF439	Tier 3 GE³, aSHM	Zhang et al
ZNF474	Tier 3 GE³, aSHM	Zhang et al
ZNF700	Tier 3 GE³, aSHM	Zhang et al
ZNF790	Tier 3 GE³, aSHM	Zhang et al
ZNF814	Tier 3 GE^{fanComprehensiveCharacterizationDriver2020b?}, aSHM	Fan et al
ZNF91	Tier 3 GE³, aSHM	Zhang et al
ZP1	Tier 3 GE³, aSHM	Zhang et al

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