Origins of DLBCL genes

Tier 1 DLBCL genes

124 total

Gene Summary First DLBCL study Other entities QC result
ACTB Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al wienandGenomicAnalysesFlowsorted2019b?
ACTG1 Tier 1 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al 1,spinaGeneticsNodalMarginal2016b?
ARID1A Tier 1 GE2, FE3 Zhang et al 4,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c?,wienandGenomicAnalysesFlowsorted2019b?
ATM Tier 1 GE5 Reddy et al 6,7
B2M Tier 1 GE8, FEchalla-malladiCombinedGeneticInactivationa? Morin et al 9,reichelFlowSortingExome2015a?
BCL10 Tier 1 GE8, FE10 Morin et al russler-germainMutationsAssociatedProgression2023b?,spinaGeneticsNodalMarginal2016b?
BCL2 Tier 1 GE11, FE12 Tanaka et al 8,burkhardtClinicalRelevanceMolecular2022b?,sarkozyMutationalLandscapeGray2021a?
BCL6 Tier 1 GE8, FE12 Morin et al 4
BCL7A Tier 1 GE8, FEbalinas-gaviraFrequentMutationsAminoterminal2020b? Morin et al 13,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
BIRC6 Tier 1 GE5 Reddy et al sarkozyMutationalLandscapeGray2021a?
BRAF Tier 1 GEtiacciBRAFMutationsHairycell2011a? Tiacci et al 4
BTG1 Tier 1 GE8, FEmlynarczykBTG1MutationYields2023b? Morin et al burkhardtClinicalRelevanceMolecular2022b?,sarkozyMutationalLandscapeGray2021a?
BTG2 Tier 1 GE8, CE14 Morin et al 4
BTK Tier 1 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al krysiakRecurrentSomaticMutations2017b?
CARD11 Tier 1 GE15, FE15, CEzhaoExpressionPrognosticValue2016? Lenz et al 8,16,yanBCRTLRSignaling2012a?
CCND3 Tier 1 GE8, FE17 Morin et al 1,18,richterRecurrentMutationID32012a?
CD58 Tier 1 GE8, FEchalla-malladiCombinedGeneticInactivationa? Morin et al schneiderAlterationsCD58Gene2015a?
CD70 Tier 1 GE8 Morin et al russler-germainMutationsAssociatedProgression2023b?
CD79B Tier 1 GE8, FE19 Morin et al 20
CD83 Tier 1 GE21 Morin et al 20,dunsCharacterizationDLBCLPMBL2021b?,russler-germainMutationsAssociatedProgression2023b?
CDKN2A Tier 1 GE21, CEjardinDiffuseLargeBcell2010a? Morin et al 13,spinaGeneticsNodalMarginal2016b?
CREBBP Tier 1 GEpasqualucciInactivatingMutationsAcetyltransferase2011a?, FEpasqualucciInactivatingMutationsAcetyltransferase2011a? Pasqualucci et al 4,22,dunsCharacterizationDLBCLPMBL2021b?
CXCR4 Tier 1 GE23 Khodabakhshi et al 20,krysiakRecurrentSomaticMutations2017b?
CXCR5 Tier 1 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al mottokIntegrativeGenomicAnalysis2019b?
DDX3X Tier 1 GE5, FE24, CEkizhakeyilDDX3XLossAdverse2021? Reddy et al 17,mottokIntegrativeGenomicAnalysis2019b?
DTX1 Tier 1 GE2, FE25, CEmerirantaDeltex1MutationsPredict2017b? Zhang et al 4,26,rossiCodingGenomeSplenic2012c?
DUSP2 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al dunsCharacterizationDLBCLPMBL2021b?
EBF1 Tier 1 GE27 Bohle et al 28,reichelFlowSortingExome2015a?
EEF1A1 Tier 1 GEhubschmannMutationalMechanismsShaping2021b?, CEgongExpressionClinicalValue2021? Hubschmann et al reichelFlowSortingExome2015a?
EP300 Tier 1 GEpasqualucciInactivatingMutationsAcetyltransferase2011a?, FEpasqualucciInactivatingMutationsAcetyltransferase2011a? Pasqualucci et al rossiCodingGenomeSplenic2012c?
ETS1 Tier 1 GE8 Morin et al 20
ETV6 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a?, CE29 Lohr et al
EZH2 Tier 1 GEmorinSomaticMutationsAltering2010a?, FEyapSomaticMutationsEZH22011b? Morin et al 4,mottokIntegrativeGenomicAnalysis2019b?
FAS Tier 1 GE30, FE31 Scholl et al spinaGeneticsNodalMarginal2016b?
FBXO11 Tier 1 GEhubschmannMutationalMechanismsShaping2021b?, FE32 Hubschmann et al 22,richterRecurrentMutationID32012a?
FBXW7 Tier 1 GE2, FE33 Zhang et al
FOXO1 Tier 1 GE8, FE34, CE34 Morin et al 17,dunsCharacterizationDLBCLPMBL2021b?
GNA13 Tier 1 GE8, FEmuppidiLossSignalingGa132014b? Morin et al 4,reichelFlowSortingExome2015a?
GNAI2 Tier 1 GE21 Morin et al 13
GRB2 Tier 1 GE35 Pasqualucci et al
GRHPR Tier 1 GE36 Arthur et al
HIST1H1B Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al krysiakRecurrentSomaticMutations2017b?,sarkozyMutationalLandscapeGray2021a?
HIST1H1C Tier 1 GE8 Morin et al 20
HIST1H1D Tier 1 GE21 Morin et al 18,krysiakRecurrentSomaticMutations2017b?
HIST1H1E Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al 13,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
HIST1H2AC Tier 1 GE21 Morin et al krysiakRecurrentSomaticMutations2017b?
HIST1H2AM Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 20,krysiakRecurrentSomaticMutations2017b?
HIST1H2BC Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al krysiakRecurrentSomaticMutations2017b?,mottokIntegrativeGenomicAnalysis2019b?
HIST1H2BK Tier 1 GE2 Zhang et al 20,rossiCodingGenomeSplenic2012c?
HIST1H3B Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al reichelFlowSortingExome2015a?
HIST2H2BE Tier 1 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
HLA-A Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al 1
HLA-B Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al wienandGenomicAnalysesFlowsorted2019b?
HLA-C Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 26
HLA-DMB Tier 1 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al
HNRNPU Tier 1 GE5 Reddy et al 20
HVCN1 Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al krysiakRecurrentSomaticMutations2017b?
IKZF3 Tier 1 GE8 Morin et al 20
IL4R Tier 1 GEdunsCharacterizationDLBCLPMBL2021b?, FEviganoSomaticIL4RMutations2018b? Duns et al viganoSomaticIL4RMutations2018b?
IRF4 Tier 1 GE8 Morin et al mottokIntegrativeGenomicAnalysis2019b?
IRF8 Tier 1 GE8, FE37 Morin et al 20,mottokIntegrativeGenomicAnalysis2019b?
ITPKB Tier 1 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al reichelFlowSortingExome2015a?
JUNB Tier 1 GE5 Reddy et al mottokIntegrativeGenomicAnalysis2019b? PASS
KLF2 Tier 1 GE35 Pasqualucci et al 1,18
KLHL14 Tier 1 GE2, FE38, CE39 Zhang et al
KLHL6 Tier 1 GE8, FE40 Morin et al 41
KMT2C Tier 1 GE2 Zhang et al 42,43,sarkozyMutationalLandscapeGray2021a?
KMT2D Tier 1 GE8, FE44, CE45 Morin et al 1,6,13,rossiCodingGenomeSplenic2012c?
KRAS Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
LCOR Tier 1 GE36 Arthur et al
LRRN3 Tier 1 GE2 Zhang et al sarkozyMutationalLandscapeGray2021a?
LTB Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 1
MEF2B Tier 1 GE8, FE46 Morin et al 6
MEF2C Tier 1 GE36, FE47 Arthur et al
MGA Tier 1 GE5, CE29 Reddy et al 18
MPEG1 Tier 1 GE21, CE29 Morin et al
MS4A1 Tier 1 GE45, FE45, CE45 Rushton et al mottokIntegrativeGenomicAnalysis2019b?
MTOR Tier 1 GE2 Zhang et al 20
MYC Tier 1 GEpasqualucciHypermutationMultipleProtooncogenes2001a?, FE48, CE49 Pasqualucci et al 18,50,dunsCharacterizationDLBCLPMBL2021b?
MYD88 Tier 1 GEngoOncogenicallyActiveMYD882011a?, FEngoOncogenicallyActiveMYD882011a?, CE29 Ngo et al yanBCRTLRSignaling2012a?
NFKBIA Tier 1 GE51 Thomas et al russler-germainMutationsAssociatedProgression2023b?,wienandGenomicAnalysesFlowsorted2019b?
NFKBIE Tier 1 GE52 Morin et al 9,53
NFKBIZ Tier 1 GE52, FE36 Morin et al
NOL9 Tier 1 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al spinaGeneticsNodalMarginal2016b?
NOTCH1 Tier 1 GE35, CE54 Pasqualucci et al 4,6,rossiCodingGenomeSplenic2012c?
NOTCH2 Tier 1 GE2, CEcampos-martinClinicalDiagnosticRelevance2017? Zhang et al 6,rossiCodingGenomeSplenic2012c?
OSBPL10 Tier 1 GE2, CEdobashiTP53OSBPL10Alterations2018b? Zhang et al
P2RY8 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a?, FEmuppidiLossSignalingGa132014b? Lohr et al muppidiLossSignalingGa132014b?
PIM1 Tier 1 GEpasqualucciHypermutationMultipleProtooncogenes2001a?, CE29 Pasqualucci et al burkhardtClinicalRelevanceMolecular2022b?,dunsCharacterizationDLBCLPMBL2021b?
PIM2 Tier 1 GE36 Arthur et al reichelFlowSortingExome2015a?
POU2AF1 Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al krysiakRecurrentSomaticMutations2017b?
POU2F2 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al krysiakRecurrentSomaticMutations2017b?
PRDM1 Tier 1 GEpasqualucciInactivationPRDM1BLIMP12006a? Pasqualucci et al
PTEN Tier 1 GE5 Reddy et al 4
RB1 Tier 1 GE21 Morin et al 42
RFX7 Tier 1 GE 13
RHOA Tier 1 GE2, FE55 Zhang et al richterRecurrentMutationID32012a?
RRAGC Tier 1 GEokosunRecurrentMTORC1activatingRRAGC2016a? Okosun et al
S1PR2 Tier 1 GE8 Morin et al muppidiLossSignalingGa132014b?
SETD1B Tier 1 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
SF3B1 Tier 1 GE5 Reddy et al 4
SGK1 Tier 1 GE8, FEhartmannHighlyRecurrentMutations2016b?, CE29 Morin et al dunsCharacterizationDLBCLPMBL2021b?
SIN3A Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 13,rossiCodingGenomeSplenic2012c?
SMARCA4 Tier 1 GE5, FE56 Reddy et al krysiakRecurrentSomaticMutations2017b?,nadeuGenomicEpigenomicInsights2020b?,richterRecurrentMutationID32012a?
SOCS1 Tier 1 GE8 Morin et al wenigerMutationsTumorSuppressor2006a?
SPEN Tier 1 GEalbuquerqueEnhancingKnowledgeDiscovery2017a?, CE29 Albuquerque et al rossiCodingGenomeSplenic2012c?,sarkozyMutationalLandscapeGray2021a?
STAT3 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
STAT6 Tier 1 GEyildizActivatingSTAT6Mutations2015c?, FEyildizActivatingSTAT6Mutations2015c? Yildiz et al ritzRecurrentMutationsSTAT62009a?
TAF1 Tier 1 GE21 Morin et al spinaGeneticsNodalMarginal2016b?
TBL1XR1 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al rossiCodingGenomeSplenic2012c?
TET2 Tier 1 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al 28
TMEM30A Tier 1 GE8, FEennishiTMEM30ALossoffunctionMutations2020b?, CEennishiTMEM30ALossoffunctionMutations2020b? Morin et al
TMSB4X Tier 1 GE2 Zhang et al
TNFAIP3 Tier 1 GEcompagnoMutationsMultipleGenes2009a? Compagno et al rossiAlterationBIRC3Multiple2011a?,schmitzTNFAIP3A20Tumor2009a?
TNFRSF14 Tier 1 GE8, CE29 Morin et al cheungAcquiredTNFRSF14Mutations2010a?,spinaGeneticsNodalMarginal2016b?
TOX Tier 1 GE5 Reddy et al
TP53 Tier 1 GElohrDiscoveryPrioritizationSomatic2012a?, FErowhTp53DeletionLineage2011? Lohr et al 6,8,57,rossiCodingGenomeSplenic2012c?,tiacciPervasiveMutationsJAKSTAT2018b?
UBE2A Tier 1 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al reichelFlowSortingExome2015a?
WEE1 Tier 1 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al reichelFlowSortingExome2015a?
XPO1 Tier 1 GE58 Mareschal et al jardinRecurrentMutationsExportin2016a?
ZC3H12A Tier 1 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al
ZFP36L1 Tier 1 GE8 Morin et al 20,reichelFlowSortingExome2015a?
ZNF292 Tier 1 GE5 Reddy et al
ZNF608 Tier 1 GE21 Morin et al krysiakRecurrentSomaticMutations2017b?

Tier 2 DLBCL genes

181 total

Gene Summary First DLBCL study Other entities QC result
ABI3BP Tier 2 GE21 Morin et al PASS
ADAMTS1 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
AICDA Tier 2 GE36 Arthur et al
ANKRD12 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
ANKRD17 Tier 2 GE2 Zhang et al
ARID5B Tier 2 GE5 Reddy et al 26 PASS
ASXL3 Tier 2 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
ATR Tier 2 GE5 Reddy et al PASS
BCL11A Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al
BCOR Tier 2 GE 18,nadeuGenomicEpigenomicInsights2020b?
BCR Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
BIRC3 Tier 2 GE36 Arthur et al 6,dunsCharacterizationDLBCLPMBL2021b?,rossiAlterationBIRC3Multiple2011a?
BLK Tier 2 GE
BRINP3 Tier 2 GE5 Reddy et al PASS
BTBD3 Tier 2 GE2 Zhang et al
CADPS2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
CASP8 Tier 2 GE5 Reddy et al
CD22 Tier 2 GE5 Reddy et al PASS
CD274 Tier 2 GE8 Morin et al
CD36 Tier 2 GE35 Pasqualucci et al
CD44 Tier 2 GE36 Arthur et al
CD74 Tier 2 GE36 Arthur et al
CDH9 Tier 2 GE21 Morin et al PASS
CEP164 Tier 2 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
CIITA Tier 2 GE8, CE29 Morin et al mottokGenomicAlterationsCIITA2015b?
CNOT2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
CNTNAP5 Tier 2 GE21 Morin et al PASS
COQ7 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
CPS1 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
CRIP1 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
DAZAP1 Tier 2 GE9 Pararajalingam et al
DDX10 Tier 2 GE2 Zhang et al
DHX16 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
DNAH5 Tier 2 GE21 Morin et al 18 PASS
DNM2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
DNMT3B Tier 2 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
DOCK1 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
DSG4 Tier 2 GE21 Morin et al PASS
EIF2AK3 Tier 2 GE
ERAP2 Tier 2 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
EZR Tier 2 GE 1
FAM102A Tier 2 GE
FANK1 Tier 2 GE
FAT2 Tier 2 GE8 Morin et al
FAT4 Tier 2 GE21 Morin et al 22,42 PASS
FCRL3 Tier 2 GE
FNBP1 Tier 2 GE
FOXC1 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
FOXP1 Tier 2 GE5 Reddy et al PASS
FUBP1 Tier 2 GE5 Reddy et al PASS
GABRA1 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
GABRA2 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al
GOLGA5 Tier 2 GE5 Reddy et al PASS
GPC5 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
GSG2 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
H1FOO Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
HDAC7 Tier 2 GE21 Morin et al PASS
HIST1H2AG Tier 2 GE21 Morin et al 20,krysiakRecurrentSomaticMutations2017b?,rossiCodingGenomeSplenic2012c? PASS
HIST1H2AL Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
HIST1H2BO Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
HLA-DMA Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al
HNF1B Tier 2 GE35 Pasqualucci et al
HNRNPD Tier 2 GE5 Reddy et al
HNRNPH1 Tier 2 GE9, FE9, CE9 Pararajalingam et al
ID3 Tier 2 GE17, FErichterRecurrentMutationID32012a? Schmitz et al richterRecurrentMutationID32012a?,spinaGeneticsNodalMarginal2016b?
IFNGR1 Tier 2 GE21 Morin et al PASS
IGLL5 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 1,20,russler-germainMutationsAssociatedProgression2023b?
IKBKB Tier 2 GE5 Reddy et al rossiAlterationBIRC3Multiple2011a?,wienandGenomicAnalysesFlowsorted2019b? PASS
IKBKE Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
IL16 Tier 2 GE5 Reddy et al
IL6 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
INO80 Tier 2 GE2 Zhang et al
IRF1 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
JAK1 Tier 2 GE2 Zhang et al mottokIntegrativeGenomicAnalysis2019b?
JAK3 Tier 2 GE2 Zhang et al
KCMF1 Tier 2 GE5 Reddy et al PASS
KLHL21 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
KRTAP5-5 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
LAMA5 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
LAPTM5 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
LPP Tier 2 GE36 Arthur et al
LRP12 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
LYN Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
MAGT1 Tier 2 GE5 Reddy et al PASS
MALAT1 Tier 2 GE36 Arthur et al
MAP2K1 Tier 2 GE59 Shin et al louissaintPediatrictypeNodalFollicular2016a?
MCL1 Tier 2 GE5 Reddy et al 20,dunsCharacterizationDLBCLPMBL2021b? PASS
MECOM Tier 2 GE5 Reddy et al PASS
MET Tier 2 GE5 Reddy et al PASS
MIR142 Tier 2 GEkwanhianMicroRNA142Mutated202012b? Kwanhian et al 13
MIR155HG Tier 2 GE
MPDZ Tier 2 GE21 Morin et al reichelFlowSortingExome2015a? PASS
MSH6 Tier 2 GE5 Reddy et al PASS
MYBPC2 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
MYO1E Tier 2 GE
MYOM2 Tier 2 GE35 Pasqualucci et al
NAV1 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al
NCOA3 Tier 2 GE
NCOR2 Tier 2 GE 17,sarkozyMutationalLandscapeGray2021a?,spinaGeneticsNodalMarginal2016b?
NEAT1 Tier 2 GE36 Arthur et al
NF1 Tier 2 GE2 Zhang et al
NFKB1 Tier 2 GE
NLRC5 Tier 2 GE
NLRP5 Tier 2 GE21 Morin et al PASS
ODZ3 Tier 2 GE21 Morin et al PASS
OR6K3 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
P2RX5 Tier 2 GE21 Morin et al PASS
PAPOLG Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
PASD1 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
PASK Tier 2 GE21 Morin et al PASS
PAX5 Tier 2 GEpasqualucciHypermutationMultipleProtooncogenes2001a? Pasqualucci et al
PCBP1 Tier 2 GE 17
PCDHB11 Tier 2 GE21 Morin et al PASS
PCDHB6 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
PCLO Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
PDGFC Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
PDS5B Tier 2 GE21 Morin et al hubschmannMutationalMechanismsShaping2021b? PASS
PIK3CD Tier 2 GE2 Zhang et al
PIK3R1 Tier 2 GE2 Zhang et al 20
PNPO Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
PPP1R9B Tier 2 GE
PRKCB Tier 2 GE21 Morin et al PASS
PRKDC Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al hubschmannMutationalMechanismsShaping2021b?
PRPS1 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS
PTMA Tier 2 GE
PTPN1 Tier 2 GE gunawardanaRecurrentSomaticMutations2014c?
PTPN6 Tier 2 GE5 Reddy et al PASS
PTPRD Tier 2 GE spinaGeneticsNodalMarginal2016b?
RAC2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
RAPGEF1 Tier 2 GE8 Morin et al
RCC Tier 2 GE
RFTN1 Tier 2 GE36 Arthur et al dunsCharacterizationDLBCLPMBL2021b?
RFXAP Tier 2 GE
RHEX Tier 2 GE
RHOH Tier 2 GEpasqualucciHypermutationMultipleProtooncogenes2001a? Pasqualucci et al
RUBCNL Tier 2 GE
S1PR1 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al 9
SAMD9L Tier 2 GE21 Morin et al PASS
SEL1L3 Tier 2 GE
SEPTIN9 Tier 2 GE
SERPINA9 Tier 2 GE36 Arthur et al
SETD2 Tier 2 GE2 Zhang et al
SETD5 Tier 2 GE5 Reddy et al tiacciPervasiveMutationsJAKSTAT2018b? PASS
SIAH2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al reichelFlowSortingExome2015a? PASS
SLC34A2 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
SLC38A8 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
SLITRK6 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
SMEK1 Tier 2 GE2 Zhang et al
SRPX Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
SRRM2 Tier 2 GE21 Morin et al russler-germainMutationsAssociatedProgression2023b? PASS
ST6GAL1 Tier 2 GE36 Arthur et al
STAT5B Tier 2 GE2 Zhang et al tiacciPervasiveMutationsJAKSTAT2018b?
SYN2 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
SYPL1 Tier 2 GE21 Morin et al PASS
TAP1 Tier 2 GEschmitzGeneticsPathogenesisDiffuse2018a? Schmitz et al
TBC1D4 Tier 2 GE36 Arthur et al
TCL1A Tier 2 GE5 Reddy et al 13
TGFBR2 Tier 2 GE5 Reddy et al PASS
TIPARP Tier 2 GE5 Reddy et al PASS
TLR2 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al 6 PASS
TMSL3 Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
TNF Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
TRAF3 Tier 2 GE35 Pasqualucci et al ottoGeneticLesionsTRAF32012a?,rossiAlterationBIRC3Multiple2011a?
TRAF6 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
TRIP12 Tier 2 GE
UBE2J1 Tier 2 GE
UBR5 Tier 2 GE2 Zhang et al 9
UHRF1BP1 Tier 2 GEalbuquerqueEnhancingKnowledgeDiscovery2017a? Albuquerque et al
UNC5B Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al PASS
UNC5C Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
UNC5D Tier 2 GElohrDiscoveryPrioritizationSomatic2012a? Lohr et al
USP7 Tier 2 GE36 Arthur et al 13
WDFY3 Tier 2 GE21 Morin et al PASS
WNK1 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al 18,28 PASS
XBP1 Tier 2 GE
YY1 Tier 2 GE5 Reddy et al PASS
ZCCHC7 Tier 2 GE36 Arthur et al
ZEB2 Tier 2 GE2 Zhang et al
ZFX Tier 2 GE5 Reddy et al PASS
ZNF217 Tier 2 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al reichelFlowSortingExome2015a? PASS
ZNF423 Tier 2 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al PASS

Tier 3 DLBCL genes

386 total

Gene Summary First DLBCL study Other entities QC result
ABCA3 Tier 3 GE2 Zhang et al 6
ABCA4 Tier 3 GE2 Zhang et al
ABCB1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ACE Tier 3 GE2 Zhang et al 4
ACSM3 Tier 3 GE2 Zhang et al
ACSS2 Tier 3 GE2 Zhang et al
ACSS3 Tier 3 GE2 Zhang et al
ACTN1 Tier 3 GE2 Zhang et al
ADAM2 Tier 3 GE2 Zhang et al
ADAMTS15 Tier 3 GE2 Zhang et al
ADH7 Tier 3 GE2 Zhang et al
AFAP1L2 Tier 3 GE2 Zhang et al
AGA Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
AHR Tier 3 GE2 Zhang et al
AKAP9 Tier 3 GE2 Zhang et al
ALAS1 Tier 3 GE2 Zhang et al
ALDH1L2 Tier 3 GE2 Zhang et al
AMAC1 Tier 3 GE2 Zhang et al
AMIGO3 Tier 3 GE2 Zhang et al
AMPH Tier 3 GE2 Zhang et al
ANK2 Tier 3 GE2 Zhang et al 42
ANKRD44 Tier 3 GE2 Zhang et al
ANTXR1 Tier 3 GE2 Zhang et al
AP1G2 Tier 3 GE2 Zhang et al
APBB1 Tier 3 GE2 Zhang et al
APC Tier 3 GE2 Zhang et al
APMAP Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
APOA5 Tier 3 GE2 Zhang et al
APP Tier 3 GE2 Zhang et al
ARID1B Tier 3 GE5 Reddy et al FAIL
ATIC Tier 3 GE2 Zhang et al
ATP10A Tier 3 GE2 Zhang et al
ATP1A2 Tier 3 GE2 Zhang et al
ATP2A3 Tier 3 GE2 Zhang et al
ATP6V0A1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
B4GALNT2 Tier 3 GE2 Zhang et al
BAZ1A Tier 3 GE2 Zhang et al
BCAT2 Tier 3 GE2 Zhang et al
BLM Tier 3 GE2 Zhang et al
BMPR1A Tier 3 GE2 Zhang et al
BRCA1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
BRCA2 Tier 3 GE2 Zhang et al
BRD4 Tier 3 GE2 Zhang et al 4
BSCL2 Tier 3 GE2 Zhang et al
BTAF1 Tier 3 GE2 Zhang et al
C9 Tier 3 GE2 Zhang et al
CAD Tier 3 GE2 Zhang et al 4
CAPN5 Tier 3 GE2 Zhang et al
CAPN7 Tier 3 GE2 Zhang et al
CBLB Tier 3 GE5 Reddy et al FAIL
CBX3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CCDC132 Tier 3 GE2 Zhang et al
CCDC46 Tier 3 GE2 Zhang et al
CCDC97 Tier 3 GE2 Zhang et al
CCL4 Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
CCNF Tier 3 GE2 Zhang et al abateDistinctViralMutational2015a?
CDC123 Tier 3 GE2 Zhang et al
CDC73 Tier 3 GE5 Reddy et al 4 FAIL
CDH10 Tier 3 GE2 Zhang et al
CDH7 Tier 3 GE2 Zhang et al
CDH8 Tier 3 GE5 Reddy et al 42 FAIL
CDK3 Tier 3 GE2 Zhang et al
CDKN1A Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CECR1 Tier 3 GE2 Zhang et al
CELSR2 Tier 3 GE2 Zhang et al
CGN Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CHD1 Tier 3 GE5 Reddy et al FAIL
CHD3 Tier 3 GE2 Zhang et al
CHEK2 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CHRM5 Tier 3 GE2 Zhang et al
CHST2 Tier 3 GE5 Reddy et al FAIL
CIC Tier 3 GE2 Zhang et al
CNGA4 Tier 3 GE2 Zhang et al
CNOT6 Tier 3 GE2 Zhang et al
CNP Tier 3 GE2 Zhang et al
CNTN6 Tier 3 GE2 Zhang et al
COL5A2 Tier 3 GE2 Zhang et al
CORO2A Tier 3 GE2 Zhang et al
CORO7 Tier 3 GE2 Zhang et al
CRELD2 Tier 3 GE2 Zhang et al
CRTC3 Tier 3 GE2 Zhang et al
CSNK1A1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CSNK2A1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
CST7 Tier 3 GE2 Zhang et al
CTNNA3 Tier 3 GE2 Zhang et al
CYP24A1 Tier 3 GE2 Zhang et al
CYP2C18 Tier 3 GE2 Zhang et al
CYYR1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
DCAF6 Tier 3 GE5 Reddy et al FAIL
DDB1 Tier 3 GE2 Zhang et al
DGCR8 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
DHX33 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
DIAPH3 Tier 3 GE2 Zhang et al
DICER1 Tier 3 GE5 Reddy et al FAIL
DIP2B Tier 3 GE2 Zhang et al
DLGAP1 Tier 3 GE2 Zhang et al 4
DMXL1 Tier 3 GE2 Zhang et al
DNMT3A Tier 3 GE5 Reddy et al FAIL
DOCK2 Tier 3 GE2 Zhang et al
DOCK5 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
DOLK Tier 3 GE2 Zhang et al
DSC2 Tier 3 GE2 Zhang et al
DSCAML1 Tier 3 GE2 Zhang et al
DSG2 Tier 3 GE2 Zhang et al
DSP Tier 3 GE2 Zhang et al
DUOXA2 Tier 3 GE2 Zhang et al
DUPD1 Tier 3 GE2 Zhang et al
DYNC1H1 Tier 3 GE2 Zhang et al
DYNC1I1 Tier 3 GE2 Zhang et al
ECGF1 Tier 3 GE2 Zhang et al
ECT2L Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
EGFR Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
EPHA3 Tier 3 GE2 Zhang et al
EPHA5 Tier 3 GE2 Zhang et al
EPHA7 Tier 3 GE2 Zhang et al mottokIntegrativeGenomicAnalysis2019b?
ERBB3 Tier 3 GE2 Zhang et al
ERN2 Tier 3 GE2 Zhang et al
ETNPPL Tier 3 GE2 Zhang et al
EXTL3 Tier 3 GE2 Zhang et al
FAIM Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
FAM161A Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
FAM38B Tier 3 GE21 Morin et al FAIL
FAM62C Tier 3 GE2 Zhang et al
FANCD2 Tier 3 GE2 Zhang et al
FGD3 Tier 3 GE2 Zhang et al
FGFR1 Tier 3 GE2 Zhang et al
FIGN Tier 3 GE2 Zhang et al
FLNA Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
FLNC Tier 3 GE2 Zhang et al
FLT1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
FMO2 Tier 3 GE2 Zhang et al
FN1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
FNDC1 Tier 3 GE21 Morin et al FAIL
FRMPD1 Tier 3 GE2 Zhang et al
FUT5 Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
FZD1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
GABRG1 Tier 3 GE2 Zhang et al
GAK Tier 3 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al FAIL
GATA2 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
GATA3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
GCN1L1 Tier 3 GE2 Zhang et al
GJA8 Tier 3 GE2 Zhang et al
GJB4 Tier 3 GE2 Zhang et al
GNAS Tier 3 GE5 Reddy et al FAIL
GOPC Tier 3 GE2 Zhang et al
GPD2 Tier 3 GE2 Zhang et al
GPR133 Tier 3 GE2 Zhang et al
GPR15 Tier 3 GE2 Zhang et al
GREM2 Tier 3 GE2 Zhang et al
GRIA2 Tier 3 GE2 Zhang et al
GRM5 Tier 3 GE2 Zhang et al
H6PD Tier 3 GE2 Zhang et al
HACE1 Tier 3 GE2 Zhang et al
HCK Tier 3 GE2 Zhang et al
HFE Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
HIPK3 Tier 3 GE2 Zhang et al
HIST1H4I Tier 3 GE2 Zhang et al
HK3 Tier 3 GE2 Zhang et al
HLA-DQA1 Tier 3 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al FAIL
HLA-DRB1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
HNRNPR Tier 3 GE2 Zhang et al
HRAS Tier 3 GE5 Reddy et al 18 FAIL
HSF2 Tier 3 GE2 Zhang et al
IDH1 Tier 3 GE2 Zhang et al
IER2 Tier 3 GE21 Morin et al FAIL
IL6ST Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
INSC Tier 3 GE2 Zhang et al
INTS6 Tier 3 GE2 Zhang et al
IQGAP1 Tier 3 GE2 Zhang et al
IQUB Tier 3 GE2 Zhang et al
ITGA2 Tier 3 GE2 Zhang et al
ITGA8 Tier 3 GE2 Zhang et al
ITGB3 Tier 3 GE2 Zhang et al
ITGB4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ITPR1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
JAG1 Tier 3 GE2 Zhang et al
JAKMIP2 Tier 3 GE2 Zhang et al
KCNA3 Tier 3 GE2 Zhang et al
KCNAB3 Tier 3 GE2 Zhang et al
KCNJ6 Tier 3 GE2 Zhang et al
KCNT2 Tier 3 GE2 Zhang et al
KDR Tier 3 GE2 Zhang et al
KIF21B Tier 3 GE2 Zhang et al
KIT Tier 3 GE2 Zhang et al
KITLG Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
KLB Tier 3 GE2 Zhang et al
KLC3 Tier 3 GE2 Zhang et al
KLF4 Tier 3 GE2 Zhang et al
KLRC4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
KRT6A Tier 3 GE2 Zhang et al
LEPR Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
LEPREL1 Tier 3 GE2 Zhang et al
LIFR Tier 3 GE2 Zhang et al
LILRA2 Tier 3 GE2 Zhang et al
LIN54 Tier 3 GE5 Reddy et al FAIL
LIN7C Tier 3 GE2 Zhang et al
LPHN2 Tier 3 GE2 Zhang et al
LRAP Tier 3 GE2 Zhang et al
LRIG3 Tier 3 GE2 Zhang et al
LRP1 Tier 3 GE2 Zhang et al
LRP10 Tier 3 GE2 Zhang et al
LRP1B Tier 3 GE2 Zhang et al spinaGeneticsNodalMarginal2016b?
LRP3 Tier 3 GE2 Zhang et al
LYST Tier 3 GE2 Zhang et al
MAP2K3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
MAP4K4 Tier 3 GE5 Reddy et al FAIL
MARCHF7 Tier 3 GE2 Zhang et al
MARK1 Tier 3 GE5 Reddy et al FAIL
MBL2 Tier 3 GE2 Zhang et al
MCM8 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
MED13L Tier 3 GE2 Zhang et al
MIB1 Tier 3 GE2 Zhang et al
MLH1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
MMEL1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
MN1 Tier 3 GE2 Zhang et al
MORC2 Tier 3 GE2 Zhang et al
MPL Tier 3 GE2 Zhang et al
MSH2 Tier 3 GE5 Reddy et al FAIL
MSN Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
MTMR3 Tier 3 GE2 Zhang et al
MYB Tier 3 GE5 Reddy et al 1 FAIL
MYL7 Tier 3 GE2 Zhang et al
MYO5C Tier 3 GE2 Zhang et al
MYRIP Tier 3 GE2 Zhang et al
NANOG Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
NCOR1 Tier 3 GE5 Reddy et al FAIL
NDUFS1 Tier 3 GE2 Zhang et al
NELL2 Tier 3 GE2 Zhang et al
NFIB Tier 3 GE2 Zhang et al
NFKB2 Tier 3 GE5 Reddy et al mottokIntegrativeGenomicAnalysis2019b? FAIL
NFX1 Tier 3 GE2 Zhang et al
NGFR Tier 3 GE2 Zhang et al
NIPBL Tier 3 GE2 Zhang et al
NLGN2 Tier 3 GE2 Zhang et al
NLRP7 Tier 3 GE2 Zhang et al
NLRP8 Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
NOTCH3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
NPHP1 Tier 3 GE2 Zhang et al
NPY2R Tier 3 GE2 Zhang et al
NR2F2 Tier 3 GEhubschmannMutationalMechanismsShaping2021b? Hubschmann et al FAIL
NRXN2 Tier 3 GE2 Zhang et al 4
NSD1 Tier 3 GE2 Zhang et al
NSD2 Tier 3 GE2 Zhang et al 6
NUP153 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ONECUT1 Tier 3 GE2 Zhang et al
PABPC1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PADI1 Tier 3 GE2 Zhang et al
PAPPA2 Tier 3 GE2 Zhang et al
PBX1 Tier 3 GE2 Zhang et al
PCCB Tier 3 GE2 Zhang et al
PCDE1C Tier 3 GE2 Zhang et al
PCDH7 Tier 3 GE2 Zhang et al
PCDHB1 Tier 3 GE2 Zhang et al
PCDHB15 Tier 3 GE2 Zhang et al
PCDHB3 Tier 3 GE2 Zhang et al
PCDHB5 Tier 3 GE2 Zhang et al
PCDHGA2 Tier 3 GE2 Zhang et al
PDE1C Tier 3 GE2 Zhang et al
PDE4DIP Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
PDGFRA Tier 3 GE2 Zhang et al
PDGFRB Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PDIA2 Tier 3 GE2 Zhang et al
PDZRN3 Tier 3 GE2 Zhang et al 20
PDZRN4 Tier 3 GE2 Zhang et al
PFN1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PGR Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PHF6 Tier 3 GE5 Reddy et al 28 FAIL
PKD1 Tier 3 GE21 Morin et al FAIL
PLA2G4B Tier 3 GE2 Zhang et al
PLCB4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PLCG2 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al 20
PLEKHA7 Tier 3 GE2 Zhang et al
PNLIPRP1 Tier 3 GE2 Zhang et al
PNPT1 Tier 3 GE2 Zhang et al
POGZ Tier 3 GE21 Morin et al FAIL
POLD3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
POLE Tier 3 GE2 Zhang et al
POLQ Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PPARGC1A Tier 3 GE2 Zhang et al
PPP2R2B Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PPWD1 Tier 3 GE2 Zhang et al
PRDM16 Tier 3 GE2 Zhang et al
PRKCB1 Tier 3 GE2 Zhang et al
PRKCQ Tier 3 GE2 Zhang et al
PROS1 Tier 3 GE2 Zhang et al
PRSS7 Tier 3 GE2 Zhang et al
PTCH1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
PTPN14 Tier 3 GE2 Zhang et al
PTPN23 Tier 3 GE21 Morin et al FAIL
PTPRF Tier 3 GE2 Zhang et al
PTPRK Tier 3 GE5 Reddy et al FAIL
PTPRT Tier 3 GE2 Zhang et al
PXK Tier 3 GE2 Zhang et al
RAB3GAP1 Tier 3 GE2 Zhang et al
RAD9A Tier 3 GEchapuyMolecularSubtypesDiffuse2018b? Chapuy et al FAIL
RAF1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al 18
RAPGEF2 Tier 3 GE2 Zhang et al
RAPGEF3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
RARA Tier 3 GE5 Reddy et al FAIL
RBM15B Tier 3 GE2 Zhang et al
RECQL4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
RELN Tier 3 GE2 Zhang et al sarkozyMutationalLandscapeGray2021a?
RET Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al 4
RFC1 Tier 3 GE2 Zhang et al
RGS1 Tier 3 GE2 Zhang et al mottokIntegrativeGenomicAnalysis2019b?
RHPN2 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
RIF1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
RIMS4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ROR2 Tier 3 GE2 Zhang et al
RPTOR Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
RSL1D1 Tier 3 GE2 Zhang et al
RUNDC1 Tier 3 GE2 Zhang et al
RUNX1 Tier 3 GE5 Reddy et al FAIL
RYR1 Tier 3 GE2 Zhang et al
SAPS3 Tier 3 GE2 Zhang et al
SARM1 Tier 3 GE21 Morin et al FAIL
SCYL1 Tier 3 GE2 Zhang et al
SEMA3A Tier 3 GE2 Zhang et al
SEMA3D Tier 3 GE2 Zhang et al
SEMA5A Tier 3 GE2 Zhang et al
SERINC2 Tier 3 GE2 Zhang et al
SH3PXD2B Tier 3 GE2 Zhang et al
SHMT2 Tier 3 GE2 Zhang et al
SIGLEC10 Tier 3 GE2 Zhang et al
SLC16A7 Tier 3 GE2 Zhang et al
SLC16A8 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
SLC4A8 Tier 3 GE2 Zhang et al
SLC5A1 Tier 3 GE2 Zhang et al
SLC9A5 Tier 3 GE2 Zhang et al
SMO Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
SOS2 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
SOX6 Tier 3 GE2 Zhang et al
SPEG Tier 3 GE2 Zhang et al
SPTBN1 Tier 3 GE2 Zhang et al
ST8SIA3 Tier 3 GE2 Zhang et al
SULF2 Tier 3 GE2 Zhang et al
SYK Tier 3 GE5 Reddy et al FAIL
TAF1L Tier 3 GE2 Zhang et al
TAF4B Tier 3 GE2 Zhang et al
TECRL Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
THBS4 Tier 3 GE2 Zhang et al
TIMM50 Tier 3 GE2 Zhang et al
TLN1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
TLN2 Tier 3 GE2 Zhang et al
TLR4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
TMC1 Tier 3 GE2 Zhang et al
TMEM161A Tier 3 GE2 Zhang et al
TMEM16E Tier 3 GE2 Zhang et al
TMEM63A Tier 3 GE2 Zhang et al
TNPO1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
TPR Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
TPRKB Tier 3 GE2 Zhang et al
TRIM37 Tier 3 GE2 Zhang et al
TRIP11 Tier 3 GE2 Zhang et al reichelFlowSortingExome2015a?
TRRAP Tier 3 GE2 Zhang et al rossiCodingGenomeSplenic2012c?
TSC2 Tier 3 GE2 Zhang et al
TSHZ2 Tier 3 GE2 Zhang et al
TYRO3 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
UBXN11 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
UBXN2B Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
UHRF1BP1L Tier 3 GE2 Zhang et al
UNC13B Tier 3 GE2 Zhang et al
UQCRC1 Tier 3 GE2 Zhang et al
VANGL1 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
VPS13A Tier 3 GE2 Zhang et al
WAC Tier 3 GE5 Reddy et al rossiCodingGenomeSplenic2012c? FAIL
WDR65 Tier 3 GE2 Zhang et al
WDR66 Tier 3 GE2 Zhang et al
WDR67 Tier 3 GE2 Zhang et al
WIF1 Tier 3 GE2 Zhang et al
WNK4 Tier 3 GE2 Zhang et al
WT1 Tier 3 GE2 Zhang et al
XDH Tier 3 GE2 Zhang et al
ZBTB7A Tier 3 GE5 Reddy et al burkhardtClinicalRelevanceMolecular2022b? FAIL
ZFAT Tier 3 GE5 Reddy et al FAIL
ZIC4 Tier 3 GE2 Zhang et al
ZMYM4 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ZNF354A Tier 3 GE2 Zhang et al
ZNF366 Tier 3 GE2 Zhang et al
ZNF439 Tier 3 GE2 Zhang et al
ZNF474 Tier 3 GE2 Zhang et al
ZNF700 Tier 3 GE2 Zhang et al
ZNF790 Tier 3 GE2 Zhang et al
ZNF814 Tier 3 GEfanComprehensiveCharacterizationDriver2020b? Fan et al
ZNF91 Tier 3 GE2 Zhang et al
ZP1 Tier 3 GE2 Zhang et al

References

1.
Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R, Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A. Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma. Leukemia. 2020 Jan;34(1):151–166.
2.
Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI, Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL, Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 2013;110:1398–1403. PMCID: PMC3557051
3.
Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A. ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Cancer Cell. 2024 Apr 8;42(4):583–604.e11.
4.
Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561
5.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841
6.
Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Croce LD, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. PNAS. 2013;110(45):18250–18255.
7.
Braggio E, Dogan A, Keats JJ, Chng WJ, Huang G, Matthews JM, Maurer MJ, Law ME, Bosler DS, Barrett M, Lossos IS, Witzig TE, Fonseca R. Genomic analysis of marginal zone and lymphoplasmacytic lymphomas identified common and disease-specific abnormalities. Mod Pathol. 2012 May;25(5):651–660. PMCID: PMC3341516
8.
Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554
9.
Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M, Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne RD, Steidl C, Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott DW, Morin RD. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Blood. 2020 Jul 30;136(5):572–584. PMCID: PMC7440974
10.
Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM. BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer Discov. 2022 Aug 5;12(8):1922–1941. PMCID: PMC9357155
11.
Tanaka S, Louie DC, Kant JA, Reed JC. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin’s lymphomas. Blood. 1992 Jan 1;79(1):229–237.
12.
Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L, Dalla-Favera R. Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature. 2022 Jul;607(7920):808–815. PMCID: PMC9583699
13.
Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019;133(12):1313–1324. PMCID: PMC6428665
14.
Guo D, Hong L, Ji H, Jiang Y, Lu L, Wang X, Huang H. The Mutation of BTG2 Gene Predicts a Poor Outcome in Primary Testicular Diffuse Large B-Cell Lymphoma. J Inflamm Res. 2022;15:1757–1769. PMCID: PMC8923029
15.
Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008 Mar;319(5870):1676–1679.
16.
Wu C, de Miranda NF, Chen L, Wasik AM, Mansouri L, Jurczak W, Galazka K, Dlugosz-Danecka M, Machaczka M, Zhang H, Peng R, Morin RD, Rosenquist R, Sander B, Pan-Hammarström Q. Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget. 2016 Jun 21;7(25):38180–38190. PMCID: PMC5122381
17.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867
18.
Jallades L, Baseggio L, Sujobert P, Huet S, Chabane K, Callet-Bauchu E, Verney A, Hayette S, Desvignes JP, Salgado D, Levy N, Béroud C, Felman P, Berger F, Magaud JP, Genestier L, Salles G, Traverse-Glehen A. Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. Haematologica. 2017 Oct;102(10):1758–1766. PMCID: PMC5622860
19.
Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Müller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010 Jan;463(7277):88–92. PMCID: PMC2845535
20.
Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;
21.
Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992
22.
Parry M, Rose-Zerilli MJJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC. Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma. PLoS One. 2013;8(12):e83244. PMCID: PMC3862727
23.
Khodabakhshi AH, Morin RD, Fejes AP, Mungall AJ, Mungall KL, Bolger-Munro M, Johnson NA, Connors JM, Gascoyne RD, Marra MA, Birol I, Jones SJM. Recurrent targets of aberrant somatic hypermutation in lymphoma. Oncotarget. 2012;3(11):1308–1319. PMCID: PMC3717795
24.
Gong C, Krupka JA, Gao J, Grigoropoulos NF, Giotopoulos G, Asby R, Screen M, Usheva Z, Cucco F, Barrans S, Painter D, Zaini NBM, Haupl B, Bornelöv S, Ruiz De Los Mozos I, Meng W, Zhou P, Blain AE, Forde S, Matthews J, Khim Tan MG, Burke GAA, Sze SK, Beer P, Burton C, Campbell P, Rand V, Turner SD, Ule J, Roman E, Tooze R, Oellerich T, Huntly BJ, Turner M, Du MQ, Samarajiwa SA, Hodson DJ. Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis. Molecular Cell. 2021;
25.
de Miranda NFCC, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, Lisboa S, Enblad G, Teixeira MR, Zeng Y, Peng R, Pan-Hammarström Q. Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients. Blood. 2014 Oct 16;124(16):2544–2553. PMCID: PMC4199956
26.
Gomez F, Fisk B, McMichael JF, Mosior M, Foltz JA, Skidmore ZL, Duncavage EJ, Miller CA, Abel H, Li YS, Russler-Germain DA, Krysiak K, Watkins MP, Ramirez CA, Schmidt A, Martins Rodrigues F, Trani L, Khanna A, Wagner JA, Fulton RS, Fronick CC, O’Laughlin MD, Schappe T, Cashen AF, Mehta-Shah N, Kahl BS, Walker J, Bartlett NL, Griffith M, Fehniger TA, Griffith OL. Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma. Cancer Res Commun. 2023 Nov 15;3(11):2312–2330. PMCID: PMC10648575
27.
Bohle V, Döring C, Hansmann M-L, Küppers R. Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Leukemia. 2013 Mar;27(3):671–679.
28.
Thomas N, Dreval K, Gerhard DS, Hilton LK, Abramson JS, Ambinder RF, Barta S, Bartlett NL, Bethony J, Bhatia K, Bowen J, Bryan AC, Cesarman E, Casper C, Chadburn A, Cruz M, Dittmer DP, Dyer MA, Farinha P, Gastier-Foster JM, Gerrie AS, Grande BM, Greiner T, Griner NB, Gross TG, Harris NL, Irvin JD, Jaffe ES, Henry D, Huppi R, Leal FE, Lee MS, Martin JP, Martin MR, Mbulaiteye SM, Mitsuyasu R, Morris V, Mullighan CG, Mungall AJ, Mungall K, Mutyaba I, Nokta M, Namirembe C, Noy A, Ogwang MD, Omoding A, Orem J, Ott G, Petrello H, Pittaluga S, Phelan JD, Ramos JC, Ratner L, Reynolds SJ, Rubinstein PG, Sissolak G, Slack G, Soudi S, Swerdlow SH, Traverse-Glehen A, Wilson WH, Wong J, Yarchoan R, ZenKlusen JC, Marra MA, Staudt LM, Scott DW, Morin RD. Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma. Blood. 2023 Feb 23;141(8):904–916. PMCID: PMC10023728
29.
Guo B, Huang Y, Duan Y, Liao C, Cen H. SGK1 mutation status can further stratify patients with germinal center B-cell-like diffuse large B-cell lymphoma into different prognostic subgroups. Cancer Med. 2022 Mar;11(5):1281–1291. PMCID: PMC8894717
30.
Scholl V, Stefanoff CG, Hassan R, Spector N, Renault IZ. Mutations within the 5’ region of FAS/CD95 gene in nodal diffuse large B-cell lymphoma. Leuk Lymphoma. 2007 May;48(5):957–963.
31.
Seeberger H, Starostik P, Schwarz S, Knörr C, Kalla J, Ott G, Müller-Hermelink HK, Greiner A. Loss of Fas (CD95/APO-1) regulatory function is an important step in early MALT-type lymphoma development. Lab Invest. 2001 Jul;81(7):977–986.
32.
Schneider C, Kon N, Amadori L, Shen Q, Schwartz FH, Tischler B, Bossennec M, Dominguez-Sola D, Bhagat G, Gu W, Basso K, Dalla-Favera R. FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease. Blood. 2016 Aug 4;128(5):660–666. PMCID: PMC9709922
33.
Saffie R, Zhou N, Rolland D, Önder Ö, Basrur V, Campbell S, Wellen KE, Elenitoba-Johnson KSJ, Capell BC, Busino L. FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells. Cancer Res. 2020 Jun 15;80(12):2498–2511. PMCID: PMC7417195
34.
Trinh DL, Scott DW, Morin RD, Mendez-Lago M, An J, Jones SJM, Mungall AJ, Zhao Y, Schein J, Steidl C, Connors JM, Gascoyne RD, Marra MA. Analysis of FOXO1 mutations in diffuse large B-cell lymphoma. Blood. 2013;121(18):3666–3674. PMCID: PMC3643765
35.
Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011 Jul 31;43(9):830–837. PMCID: PMC3297422
36.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379
37.
Qiu Z, Khalife J, Ethiraj P, Jaafar C, Lin AP, Holder KN, Ritter JP, Chiou L, Huelgas-Morales G, Aslam S, Zhang Z, Liu Z, Arya S, Gupta YK, Dahia PLM, Aguiar RCT. IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHCII complexes. Sci Adv. 2024 Jul 12;10(28):eadk2091. PMCID: PMC11244530
38.
Choi J, Phelan JD, Wright GW, Häupl B, Huang DW, Shaffer AL, Young RM, Wang Z, Zhao H, Yu X, Oellerich T, Staudt LM. Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6092–6102. PMCID: PMC7084139
39.
Hodkinson BP, Schaffer M, Brody JD, Jurczak W, Carpio C, Ben-Yehuda D, Avivi I, Forslund A, Özcan M, Alvarez J, Ceulemans R, Fourneau N, Younes A, Balasubramanian S. Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter’s transformation. Transl Oncol. 2021 Jan;14(1):100977. PMCID: PMC7723809
40.
Meriranta L, Sorri S, Huse K, Liu X, Spasevska I, Zafar S, Chowdhury I, Dufva O, Sahlberg E, Tandaric L, Karjalainen-Lindsberg ML, Hyytiainen M, Varjosalo M, Myklebust JH, Leppa S. Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma. Blood Cancer Discov. 2024 Apr 17;
41.
Ganapathi KA, Jobanputra V, Iwamoto F, Jain P, Chen J, Cascione L, Nahum O, Levy B, Xie Y, Khattar P, Hoehn D, Bertoni F, Murty VV, Pittaluga S, Jaffe ES, Alobeid B, Mansukhani MM, Bhagat G. The genetic landscape of dural marginal zone lymphomas. Oncotarget. Impact Journals; 2016 May 27;7(28):43052–43061.
42.
Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.
43.
Zhou P, Blain AE, Newman AM, Zaka M, Chagaluka G, Adlar FR, Offor UT, Broadbent C, Chaytor L, Whitehead A, Hall A, O’Connor H, Van Noorden S, Lampert I, Bailey S, Molyneux E, Bacon CM, Bomken S, Rand V. Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif. Blood Adv. 2019 Jul 23;3(14):2118–2127. PMCID: PMC6650741
44.
Li J, Chin CR, Ying HY, Meydan C, Teater MR, Xia M, Farinha P, Takata K, Chu CS, Jiang Y, Eagles J, Passerini V, Tang Z, Rivas MA, Weigert O, Pugh TJ, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason CE, Zappasodi R, Béguelin W, Melnick AM. Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nat Commun. 2024 Apr 3;15(1):2879. PMCID: PMC10991284
45.
Rushton CK, Arthur SE, Alcaide M, Cheung M, Jiang A, Coyle KM, Cleary KLS, Thomas N, Hilton LK, Michaud N, Daigle S, Davidson J, Bushell K, Yu S, Rys RN, Jain M, Shepherd L, Marra MA, Kuruvilla J, Crump M, Mann K, Assouline S, Connors JM, Steidl C, Cragg MS, Scott DW, Johnson NA, Morin RD. Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma. Blood Adv. 2020 Jul 14;4(13):2886–2898. PMCID: PMC7362366
46.
Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R. MEF2B Mutations Lead to De-Regulated Expression of the BCL6 Oncogene in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma. Blood. 120.
47.
Jingjing Z, Lei M, Jie Z, Sha C, Yapeng H, Weimin Z, Chunluan Y. A novel MEF2C mutation in lymphoid neoplasm diffuse large B-cell lymphoma promotes tumorigenesis by increasing c-JUN expression. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393(8):1549–1558.
48.
Giallongo A, Appella E, Ricciardi R, Rovera G, Croce CM. Identification of the c-myc oncogene product in normal and malignant B cells. Science. 1983 Oct 28;222(4622):430–432.
49.
Christie L, Kernohan N, Levison D, Sales M, Cunningham J, Gillespie K, Batstone P, Meiklejohn D, Goodlad J. C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: An adverse prognostic indicator? Leuk Lymphoma. 2008 Mar;49(3):470–476.
50.
Johnston JM, Carroll WL. C-myc hypermutation in Burkitt’s lymphoma. Leuk Lymphoma. 1992 Dec;8(6):431–439.
51.
Thomas RK, Wickenhauser C, Tawadros S, Diehl V, Küppers R, Wolf J, Schmitz R. Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma. Br J Haematol. 2004 Jul;126(1):50–54.
52.
Morin RD, Assouline S, Alcaide M, Mohajeri A, Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH, Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D, Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y, Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E, Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA. Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas. Clin Cancer Res. 2016 May 1;22(9):2290–2300.
53.
Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N, Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG, Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann ML, Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M, Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A, Ogawa S, Küppers R, Stamatopoulos K, Stavroyianni N, Kanellis G, Rosenwald A, Campo E, Amini RM, Ott G, Vassilakopoulos TP, Hummel M, Rosenquist R, Damm F. Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood. 2016 Dec 8;128(23):2666–2670.
54.
Kridel R, Meissner B, Rogic S, Boyle M, Telenius A, Woolcock B, Gunawardana J, Jenkins C, Cochrane C, Ben-Neriah S, Tan K, Morin RD, Opat S, Sehn LH, Connors JM, Marra MA, Weng AP, Steidl C, Gascoyne RD. Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma. Blood. 2012 Mar 1;119(9):1963–1971.
55.
O’Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS. Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: A tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016 Jul 21;35(29):3771–3780. PMCID: PMC4885800
56.
Deng Q, Lakra P, Gou P, Yang H, Meydan C, Teater M, Chin C, Zhang W, Dinh T, Hussein U, Li X, Rojas E, Liu W, Reville PK, Kizhakeyil A, Barisic D, Parsons S, Wilson A, Henderson J, Scull B, Gurumurthy C, Vega F, Chadburn A, Cuglievan B, El-Mallawany NK, Allen C, Mason C, Melnick A, Green MR. SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer Cell. 2024 Apr 8;42(4):605–622.e11. PMCID: PMC11003852
57.
Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A, Woessmann W. Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt’s lymphoma in children. Leukemia. 2004 Mar;18(3):584–588.
58.
Mareschal S, Dubois S, Viailly PJ, Bertrand P, Bohers E, Maingonnat C, Jaïs JP, Tesson B, Ruminy P, Peyrouze P, Copie-Bergman C, Fest T, Jo Molina T, Haioun C, Salles G, Tilly H, Lecroq T, Leroy K, Jardin F. Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma. Genes Chromosomes Cancer. 2016 Mar;55(3):251–267.
59.
Shin SY, Lee ST, Kim HJ, Ki CS, Jung CW, Kim JW, Kim SH. BRAF V600E and MAP2K1 mutations in hairy cell leukemia and splenic marginal zone lymphoma cases. Ann Lab Med. 2015 Mar;35(2):257–259. PMCID: PMC4330180

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.