Origins of DLBCL genes

Tier 1 DLBCL genes

129 total

Gene Tier First DLBCL evidence Other entities
ACTB 1, aSHM lohrDiscoveryPrioritizationSomatic2012a? wienandGenomicAnalysesFlowsorted2019b?
ACTG1 1, aSHM hubschmannMutationalMechanismsShaping2021b? 1,spinaGeneticsNodalMarginal2016b?
ARID1A 1 2 3,wienandGenomicAnalysesFlowsorted2019b?,rossiCodingGenomeSplenic2012c?,krysiakRecurrentSomaticMutations2017b?
ATM 1 4 5,6
B2M 1 7 8,reichelFlowSortingExome2015a?
BCL10 1 7 spinaGeneticsNodalMarginal2016b?,russler-germainMutationsAssociatedProgression2023b?
BCL2 1, aSHM 9 7,sarkozyMutationalLandscapeGray2021a?,burkhardtClinicalRelevanceMolecular2022b?
BCL6 1, aSHM 7 3
BCL7A 1, aSHM 10 11,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
BIRC6 1 4 sarkozyMutationalLandscapeGray2021a?
BRAF 1 tiacciBRAFMutationsHairycell2011a? 3
BTG1 1, aSHM 7 sarkozyMutationalLandscapeGray2021a?,burkhardtClinicalRelevanceMolecular2022b?
BTG2 1, aSHM 7 3
BTK 1 albuquerqueEnhancingKnowledgeDiscovery2017a? krysiakRecurrentSomaticMutations2017b?
CARD11 1 12 7,13,14,yanBCRTLRSignaling2012a?
CASP8 2 4
CCND3 1 7 1,15,richterRecurrentMutationID32012a?
CD58 1 7 schneiderAlterationsCD58Gene2015a?
CD70 1 7 russler-germainMutationsAssociatedProgression2023b?
CD79B 1 7 14
CD83 1, aSHM 16 14,russler-germainMutationsAssociatedProgression2023b?,dunsCharacterizationDLBCLPMBL2021b?
CDKN2A 1 16 11,spinaGeneticsNodalMarginal2016b?
CIITA 1, aSHM 7 mottokGenomicAlterationsCIITA2015b?
CREBBP 1 pasqualucciInactivatingMutationsAcetyltransferase2011a? 3,17,dunsCharacterizationDLBCLPMBL2021b?
CXCR4 1, aSHM 18 14,krysiakRecurrentSomaticMutations2017b?
CXCR5 1 schmitzGeneticsPathogenesisDiffuse2018a? mottokIntegrativeGenomicAnalysis2019b?
DDX3X 1 schmitzGeneticsPathogenesisDiffuse2018a? 19,mottokIntegrativeGenomicAnalysis2019b?
DTX1 1, aSHM schmitzGeneticsPathogenesisDiffuse2018a? 14,20,rossiCodingGenomeSplenic2012c?
DUSP2 1, aSHM 16 dunsCharacterizationDLBCLPMBL2021b?
EBF1 1, aSHM 21 22,reichelFlowSortingExome2015a?
EEF1A1 1 hubschmannMutationalMechanismsShaping2021b? reichelFlowSortingExome2015a?
EP300 1 pasqualucciInactivatingMutationsAcetyltransferase2011a? 14,rossiCodingGenomeSplenic2012c?
ETS1 1, aSHM 7 14
ETV6 1, aSHM 10
EZH2 1 morinSomaticMutationsAltering2010a? 3,mottokIntegrativeGenomicAnalysis2019b?
FAS 1 23 spinaGeneticsNodalMarginal2016b?
FBXO11 1 hubschmannMutationalMechanismsShaping2021b? 17,richterRecurrentMutationID32012a?
FBXW7 1 2
FOXO1 1 7 19,dunsCharacterizationDLBCLPMBL2021b?
GNA13 1 7 3,reichelFlowSortingExome2015a?
GNAI2 1 16 11
GRB2 1 24 14
GRHPR 1, aSHM 10
HIST1H1B 1, aSHM chapuyMolecularSubtypesDiffuse2018b? sarkozyMutationalLandscapeGray2021a?,krysiakRecurrentSomaticMutations2017b?
HIST1H1C 1, aSHM 7 14
HIST1H1D 1, aSHM 16 15,krysiakRecurrentSomaticMutations2017b?
HIST1H1E 1, aSHM 16 11,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
HIST1H2AC 1, aSHM 16 krysiakRecurrentSomaticMutations2017b?
HIST1H2AM 1, aSHM 14,krysiakRecurrentSomaticMutations2017b?
HIST1H2BC 1, aSHM 4 krysiakRecurrentSomaticMutations2017b?,mottokIntegrativeGenomicAnalysis2019b?
HIST1H2BK 1, aSHM 14,rossiCodingGenomeSplenic2012c?
HIST1H3B 1, aSHM 2 reichelFlowSortingExome2015a?
HIST2H2BE 1, aSHM schmitzGeneticsPathogenesisDiffuse2018a?
HLA-A 1 1
HLA-B 1 wienandGenomicAnalysesFlowsorted2019b?
HLA-C 1 20
HLA-DMB 1
HNRNPU 1, aSHM 4 14
HVCN1 1 krysiakRecurrentSomaticMutations2017b?
IKZF3 1 16 14
IL4R 1, aSHM dunsCharacterizationDLBCLPMBL2021b? viganoSomaticIL4RMutations2018b?
IRF4 1, aSHM 7 mottokIntegrativeGenomicAnalysis2019b?
IRF8 1, aSHM 7 14,mottokIntegrativeGenomicAnalysis2019b?
ITPKB 1, aSHM schmitzGeneticsPathogenesisDiffuse2018a? reichelFlowSortingExome2015a?
KLF2 1, aSHM 24 1,15
KLHL14 1 2
KLHL6 1, aSHM 7 14,25
KMT2C 1 2 26,27,sarkozyMutationalLandscapeGray2021a?
KMT2D 1 7 1,6,11,rossiCodingGenomeSplenic2012c?
KRAS 1 lohrDiscoveryPrioritizationSomatic2012a?
LCOR 1 10
LTB 1, aSHM chapuyMolecularSubtypesDiffuse2018b? 1,14
MEF2B 1, aSHM 7 6
MEF2C 1, aSHM 10
MGA 1 2 15
MPEG1 1 16
MS4A1 1, aSHM 28 mottokIntegrativeGenomicAnalysis2019b?
MTOR 1 2 14
MYC 1, aSHM pasqualucciHypermutationMultipleProtooncogenes2001a? 15,29,dunsCharacterizationDLBCLPMBL2021b?
MYD88 1 ngoOncogenicallyActiveMYD882011a? yanBCRTLRSignaling2012a?
NFKBIA 1 30 russler-germainMutationsAssociatedProgression2023b?,wienandGenomicAnalysesFlowsorted2019b?
NFKBIE 1 31 8,32
NFKBIZ 1, noncoding 31
NOL9 1, aSHM schmitzGeneticsPathogenesisDiffuse2018a? spinaGeneticsNodalMarginal2016b?
NOTCH1 1 24 3,6,rossiCodingGenomeSplenic2012c?
NOTCH2 1 33 6,14,rossiCodingGenomeSplenic2012c?
OSBPL10 1, aSHM 10
P2RY8 1 lohrDiscoveryPrioritizationSomatic2012a? muppidiLossSignalingGa132014b?
PIM1 1, aSHM pasqualucciHypermutationMultipleProtooncogenes2001a? burkhardtClinicalRelevanceMolecular2022b?,dunsCharacterizationDLBCLPMBL2021b?
PIM2 1, aSHM 10 reichelFlowSortingExome2015a?
POU2AF1 1, aSHM krysiakRecurrentSomaticMutations2017b?
POU2F2 1 2 krysiakRecurrentSomaticMutations2017b?
PRDM1 1 pasqualucciInactivationPRDM1BLIMP12006a?
PTEN 1 3
PTPRD 1 spinaGeneticsNodalMarginal2016b?
RB1 1 16 27
RFX7 1 11
RHOA 1 richterRecurrentMutationID32012a?
RRAGC 1 okosunRecurrentMTORC1activatingRRAGC2016a?
S1PR2 1, aSHM 7 muppidiLossSignalingGa132014b?
SETD1B 1 4
SF3B1 1 3
SGK1 1, aSHM 7 dunsCharacterizationDLBCLPMBL2021b?
SIN3A 1 11,rossiCodingGenomeSplenic2012c?
SMARCA4 1 2 nadeuGenomicEpigenomicInsights2020b?,krysiakRecurrentSomaticMutations2017b?,richterRecurrentMutationID32012a?
SOCS1 1, aSHM 7 wenigerMutationsTumorSuppressor2006a?
SPEN 1 rossiCodingGenomeSplenic2012c? sarkozyMutationalLandscapeGray2021a?
STAT3 1 34
STAT6 1 yildizActivatingSTAT6Mutations2015c? ritzRecurrentMutationsSTAT62009a?
TAF1 1 16 spinaGeneticsNodalMarginal2016b?
TBL1XR1 1 35 rossiCodingGenomeSplenic2012c?
TET2 1 albuquerqueEnhancingKnowledgeDiscovery2017a? 14
TMEM30A 1 7
TMSB4X 1, aSHM albuquerqueEnhancingKnowledgeDiscovery2017a?
TNFAIP3 1 compagnoMutationsMultipleGenes2009a? schmitzTNFAIP3A20Tumor2009a?,rossiAlterationBIRC3Multiple2011a?
TNFRSF14 1 cheungAcquiredTNFRSF14Mutations2010a? spinaGeneticsNodalMarginal2016b?
TOX 1 4
TP53 1 6,7,36,tiacciPervasiveMutationsJAKSTAT2018b?,rossiCodingGenomeSplenic2012c?
TRRAP 1 17 rossiCodingGenomeSplenic2012c?
UBE2A 1 4 reichelFlowSortingExome2015a?
UNC5C 1
USP7 1 11
VPS13B 1
WEE1 1 schmitzGeneticsPathogenesisDiffuse2018a? reichelFlowSortingExome2015a?
XPO1 1 35 jardinRecurrentMutationsExportin2016a?
ZC3H12A 1 10
ZFP36L1 1, aSHM 7 14,reichelFlowSortingExome2015a?
ZNF292 1 2
ZNF608 1, aSHM 2 krysiakRecurrentSomaticMutations2017b?

Tier 2 DLBCL genes

196 total

Gene Tier First DLBCL evidence Other entities
ABI3BP 2 16
ADAMTS1 2 hubschmannMutationalMechanismsShaping2021b?
AICDA 2, aSHM 10
ANKRD12 2 hubschmannMutationalMechanismsShaping2021b?
ANKRD17 2 4
ARID1B 2 4
ARID5B 2 4 20
ATR 2 4
BCL11A 2, aSHM
BCOR 2 15,nadeuGenomicEpigenomicInsights2020b?
BCR 2, aSHM
BIRC3 2, aSHM 10 6,rossiAlterationBIRC3Multiple2011a?,dunsCharacterizationDLBCLPMBL2021b?
BLK 2, aSHM
BRINP3 2 4
BTBD3 2 4
CADPS2 2 hubschmannMutationalMechanismsShaping2021b?
CBLB 2 4
CCL4 2 chapuyMolecularSubtypesDiffuse2018b?
CD22 2 4
CD274 2 7
CD36 2 24
CD44 2, aSHM 10
CD74 2, aSHM 10
CDC73 2 4 3
CDH9 2 16
CHD1 2 4
CHD8 2 4 11
CHST2 2 4
CNOT2 2 hubschmannMutationalMechanismsShaping2021b?
CNTNAP5 2 16
COQ7 2 chapuyMolecularSubtypesDiffuse2018b?
CRIP1 2 chapuyMolecularSubtypesDiffuse2018b?
DAZAP1 2 8
DCAF6 2 4
DDX10 2 4
DHX16 2 hubschmannMutationalMechanismsShaping2021b?
DICER1 2 4
DNAH5 2 16 15
DNM2 2 hubschmannMutationalMechanismsShaping2021b?
DNMT3A 2 4
DOCK1 2 chapuyMolecularSubtypesDiffuse2018b?
DSG4 2 16
EIF2AK3 2, aSHM
EZR 2, aSHM 1
FAM102A 2, aSHM
FAM38B 2 16
FANK1 2, aSHM
FAT4 2 16 17,27
FCRL3 2, aSHM
FNBP1 2, aSHM
FNDC1 2 16
FOXC1 2 schmitzGeneticsPathogenesisDiffuse2018a?
FOXP1 2, aSHM 4
FUBP1 2 4
FUT5 2 chapuyMolecularSubtypesDiffuse2018b?
GABRA2 2 chapuyMolecularSubtypesDiffuse2018b?
GAK 2 hubschmannMutationalMechanismsShaping2021b?
GNAS 2 4
GOLGA5 2 4
GPC5 2 schmitzGeneticsPathogenesisDiffuse2018a?
GSG2 2 schmitzGeneticsPathogenesisDiffuse2018a?
HDAC7 2 16
HIST1H2AG 2, aSHM 16 14,rossiCodingGenomeSplenic2012c?,krysiakRecurrentSomaticMutations2017b?
HLA-DMA 2
HLA-DQA1 2 hubschmannMutationalMechanismsShaping2021b?
HNF1B 2 24
HNRNPD 2
HNRNPH1 2, noncoding 8
HRAS 2 4 15
ID3 2 19 spinaGeneticsNodalMarginal2016b?,richterRecurrentMutationID32012a?
IER2 2 16
IFNGR1 2 16
IGLL5 2, aSHM 1,14,russler-germainMutationsAssociatedProgression2023b?
IKBKB 2 4 rossiAlterationBIRC3Multiple2011a?,wienandGenomicAnalysesFlowsorted2019b?
IKBKE 2 hubschmannMutationalMechanismsShaping2021b?
IL16 2
IL6 2 chapuyMolecularSubtypesDiffuse2018b?
INO80 2 2
IRAG2 2, aSHM
IRF1 2, aSHM hubschmannMutationalMechanismsShaping2021b?
JAK1 2 2 mottokIntegrativeGenomicAnalysis2019b?
JAK3 2 2
JUNB 2 4 mottokIntegrativeGenomicAnalysis2019b?
KCMF1 2 4
KLHL21 2 schmitzGeneticsPathogenesisDiffuse2018a?
LAMA5 2 schmitzGeneticsPathogenesisDiffuse2018a?
LAPTM5 2, aSHM hubschmannMutationalMechanismsShaping2021b?
LIN54 2 4
LPP 2, aSHM 10
LRP12 2 hubschmannMutationalMechanismsShaping2021b?
LRRN3 2 16 sarkozyMutationalLandscapeGray2021a?
LYN 2 chapuyMolecularSubtypesDiffuse2018b?
MAGT1 2 4
MALAT1 2, aSHM 10
MAP2K1 2 37 louissaintPediatrictypeNodalFollicular2016a?
MAP4K4 2 4
MARK1 2 4
MCL1 2 4 14,dunsCharacterizationDLBCLPMBL2021b?
MECOM 2 4
MET 2 4
MIR142 2, aSHM kwanhianMicroRNA142Mutated202012b? 11
MIR155HG 2, aSHM
MPDZ 2 16 reichelFlowSortingExome2015a?
MSH2 2 4
MSH6 2 4
MYB 2 4 1
MYBPC2 2 schmitzGeneticsPathogenesisDiffuse2018a?
MYO1E 2, aSHM
MYOM2 2 24
NR2F2 2 hubschmannMutationalMechanismsShaping2021b?
NANOG 2 chapuyMolecularSubtypesDiffuse2018b?
NAV1 2 chapuyMolecularSubtypesDiffuse2018b?
NCOA3 2, aSHM
NCOR1 2 4
NCOR2 2 19,spinaGeneticsNodalMarginal2016b?,sarkozyMutationalLandscapeGray2021a?
NEAT1 2, aSHM 10
NF1 2 4
NFKB1 2
NFKB2 2 4 mottokIntegrativeGenomicAnalysis2019b?
NLRC5 2
NLRP5 2 16
NLRP8 2 chapuyMolecularSubtypesDiffuse2018b?
ODZ3 2 16
P2RX5 2, aSHM 16
PAPOLG 2 schmitzGeneticsPathogenesisDiffuse2018a?
PASK 2 16
PAX5 2, aSHM pasqualucciHypermutationMultipleProtooncogenes2001a?
PCBP1 2 19
PCDHB11 2 16
PCLO 2 lohrDiscoveryPrioritizationSomatic2012a?
PDE4DIP 2 chapuyMolecularSubtypesDiffuse2018b?
PDS5B 2 16 hubschmannMutationalMechanismsShaping2021b?
PHF6 2 4 22
PIK3CD 2 4
PIK3R1 2 2 14
PKD1 2 16
PNPO 2 hubschmannMutationalMechanismsShaping2021b?
POGZ 2 16
PPP1R9B 2
PRKCB 2 16
PRKDC 2 schmitzGeneticsPathogenesisDiffuse2018a? hubschmannMutationalMechanismsShaping2021b?
PRPS1 2 chapuyMolecularSubtypesDiffuse2018b?
PTMA 2, aSHM
PTPN1 2, aSHM gunawardanaRecurrentSomaticMutations2014c?
PTPN23 2 16
PTPN6 2 4
PTPRK 2 4
RAC2 2 hubschmannMutationalMechanismsShaping2021b? 14
RAD9A 2 chapuyMolecularSubtypesDiffuse2018b?
RARA 2 4
RCC 2, aSHM
RFTN1 2, aSHM 10 dunsCharacterizationDLBCLPMBL2021b?
RFXAP 2
RHEX 2, aSHM
RHOH 2, aSHM pasqualucciHypermutationMultipleProtooncogenes2001a?
RUBCNL 2, aSHM
RUNX1 2 4
SAMD9L 2 16
SARM1 2 16
SEL1L3 2, aSHM
SEPTIN9 2, aSHM
SERPINA9 2, aSHM 10
SETD2 2 2
SETD5 2 4 tiacciPervasiveMutationsJAKSTAT2018b?
SIAH2 2 hubschmannMutationalMechanismsShaping2021b? reichelFlowSortingExome2015a?
SLC34A2 2 hubschmannMutationalMechanismsShaping2021b?
SMEK1 2 chapuyMolecularSubtypesDiffuse2018b?
SRRM2 2 16 russler-germainMutationsAssociatedProgression2023b?
ST6GAL1 2, aSHM 10
STAT5B 2 2 tiacciPervasiveMutationsJAKSTAT2018b?
SYK 2 4
SYPL1 2 16
TAP1 2 schmitzGeneticsPathogenesisDiffuse2018a?
TBC1D4 2, aSHM 10
TCL1A 2, aSHM 11
TGFBR2 2 4
TIPARP 2 4
TLR2 2 chapuyMolecularSubtypesDiffuse2018b? 6
TRAF3 2 24 rossiAlterationBIRC3Multiple2011a?,ottoGeneticLesionsTRAF32012a?
TRAF6 2 hubschmannMutationalMechanismsShaping2021b?
TRIP12 2
UBE2J1 2, aSHM
UBR5 2 2 8
UNC5B 2 hubschmannMutationalMechanismsShaping2021b?
UNC5D 2
WAC 2 4 rossiCodingGenomeSplenic2012c?
WDFY3 2 16
WNK1 2 hubschmannMutationalMechanismsShaping2021b? 15,22
YY1 2 4
ZBTB7A 2 4 burkhardtClinicalRelevanceMolecular2022b?
ZCCHC7 2, aSHM 10
ZEB2 2 2
ZFAT 2 4
ZFX 2 4
ZNF217 2 hubschmannMutationalMechanismsShaping2021b? reichelFlowSortingExome2015a?
ZNF423 2 chapuyMolecularSubtypesDiffuse2018b?

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