DLBCL genes

Origins of DLBCL genessankey

Tier 1 DLBCL genes

128 total

Gene Tier Relevant references
ACTB 1, aSHM (wienandGenomicAnalysesFlowsorted2019b?; lohrDiscoveryPrioritizationSomatic2012a?)
ACTG1 1, aSHM (spinaGeneticsNodalMarginal2016b?; Desch et al. 2020; hubschmannMutationalMechanismsShaping2021b?)
ARID1A 1 (rossiCodingGenomeSplenic2012c?; wienandGenomicAnalysesFlowsorted2019b?; Love et al. 2012; Zhang et al. 2013; krysiakRecurrentSomaticMutations2017b?)
ATM 1 (Braggio et al. 2012; Beà et al. 2013; Reddy et al. 2017)
B2M 1 (Pararajalingam et al. 2020; reichelFlowSortingExome2015a?; Morin et al. 2011)
BCL10 1 (Morin et al. 2011; russler-germainMutationsAssociatedProgression2023b?; spinaGeneticsNodalMarginal2016b?)
BCL2 1, aSHM (sarkozyMutationalLandscapeGray2021a?; Tanaka et al. 1992; burkhardtClinicalRelevanceMolecular2022b?; Morin et al. 2011)
BCL6 1, aSHM (Morin et al. 2011; Love et al. 2012)
BCL7A 1, aSHM (reichelFlowSortingExome2015a?; krysiakRecurrentSomaticMutations2017b?; Arthur et al. 2018; Grande et al. 2019)
BIRC6 1 (Reddy et al. 2017; sarkozyMutationalLandscapeGray2021a?)
BRAF 1 (Love et al. 2012; tiacciBRAFMutationsHairycell2011a?)
BTG1 1, aSHM (Morin et al. 2011; burkhardtClinicalRelevanceMolecular2022b?; sarkozyMutationalLandscapeGray2021a?)
BTG2 1, aSHM (Morin et al. 2011; Love et al. 2012)
BTK 1 (krysiakRecurrentSomaticMutations2017b?; albuquerqueEnhancingKnowledgeDiscovery2017a?)
CARD11 1 (Wu et al. 2016; Panea et al. 2019; Lenz et al. 2008; yanBCRTLRSignaling2012a?; Morin et al. 2011)
CCND3 1 (Jallades et al. 2017; richterRecurrentMutationID32012a?; Desch et al. 2020; Morin et al. 2011)
CD58 1 (Morin et al. 2011; schneiderAlterationsCD58Gene2015a?)
CD70 1 (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2011)
CD79B 1 (Morin et al. 2011; Panea et al. 2019)
CD83 1, aSHM (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2013; dunsCharacterizationDLBCLPMBL2021b?; Panea et al. 2019)
CDKN2A 1 (Grande et al. 2019; spinaGeneticsNodalMarginal2016b?; Morin et al. 2013)
CIITA 1, aSHM (mottokGenomicAlterationsCIITA2015b?; Morin et al. 2011)
CREBBP 1 (dunsCharacterizationDLBCLPMBL2021b?; pasqualucciInactivatingMutationsAcetyltransferase2011a?; Love et al. 2012; Parry et al. 2013)
CXCR4 1, aSHM (Khodabakhshi et al. 2012; Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?)
CXCR5 1 (schmitzGeneticsPathogenesisDiffuse2018a?; mottokIntegrativeGenomicAnalysis2019b?)
DDX3X 1 (Schmitz et al. 2012; mottokIntegrativeGenomicAnalysis2019b?; schmitzGeneticsPathogenesisDiffuse2018a?)
DTX1 1, aSHM (Panea et al. 2019; Gomez et al. 2023; schmitzGeneticsPathogenesisDiffuse2018a?; rossiCodingGenomeSplenic2012c?)
DUSP2 1, aSHM (dunsCharacterizationDLBCLPMBL2021b?; Morin et al. 2013)
EBF1 1, aSHM (reichelFlowSortingExome2015a?; Bohle et al. 2013; Thomas et al. 2023)
EEF1A1 1 (hubschmannMutationalMechanismsShaping2021b?; reichelFlowSortingExome2015a?)
EP300 1 (rossiCodingGenomeSplenic2012c?; Panea et al. 2019; pasqualucciInactivatingMutationsAcetyltransferase2011a?)
ETS1 1, aSHM (Panea et al. 2019; Morin et al. 2011)
ETV6 1, aSHM (Arthur et al. 2018)
EZH2 1 (morinSomaticMutationsAltering2010a?; mottokIntegrativeGenomicAnalysis2019b?; Love et al. 2012)
FAS 1 (Scholl et al. 2007; spinaGeneticsNodalMarginal2016b?)
FBXO11 1 (richterRecurrentMutationID32012a?; hubschmannMutationalMechanismsShaping2021b?; Parry et al. 2013)
FBXW7 1 (Zhang et al. 2013)
FOXO1 1 (Schmitz et al. 2012; Morin et al. 2011; dunsCharacterizationDLBCLPMBL2021b?)
GNA13 1 (Love et al. 2012; Morin et al. 2011; reichelFlowSortingExome2015a?)
GNAI2 1 (Grande et al. 2019; Morin et al. 2013)
GRB2 1 (Panea et al. 2019; Pasqualucci et al. 2011)
GRHPR 1, aSHM (Arthur et al. 2018)
HIST1H1B 1, aSHM (krysiakRecurrentSomaticMutations2017b?; sarkozyMutationalLandscapeGray2021a?; chapuyMolecularSubtypesDiffuse2018b?)
HIST1H1C 1, aSHM (Morin et al. 2011; Panea et al. 2019)
HIST1H1D 1, aSHM (krysiakRecurrentSomaticMutations2017b?; Jallades et al. 2017; Morin et al. 2013)
HIST1H1E 1, aSHM (Morin et al. 2013; reichelFlowSortingExome2015a?; Grande et al. 2019; krysiakRecurrentSomaticMutations2017b?)
HIST1H2AC 1, aSHM (krysiakRecurrentSomaticMutations2017b?; Morin et al. 2013)
HIST1H2AM 1, aSHM (Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?)
HIST1H2BC 1, aSHM (krysiakRecurrentSomaticMutations2017b?; mottokIntegrativeGenomicAnalysis2019b?; Reddy et al. 2017)
HIST1H2BK 1, aSHM (Panea et al. 2019; rossiCodingGenomeSplenic2012c?)
HIST1H3B 1, aSHM (Zhang et al. 2013; reichelFlowSortingExome2015a?)
HIST2H2BE 1, aSHM (schmitzGeneticsPathogenesisDiffuse2018a?)
HLA-A 1 (Desch et al. 2020)
HLA-B 1 (wienandGenomicAnalysesFlowsorted2019b?)
HLA-C 1 (Gomez et al. 2023)
HLA-DMB 1
HNRNPU 1, aSHM (Panea et al. 2019; Reddy et al. 2017)
HVCN1 1 (krysiakRecurrentSomaticMutations2017b?)
IKZF3 1 (Morin et al. 2013; Panea et al. 2019)
IL4R 1, aSHM (dunsCharacterizationDLBCLPMBL2021b?; viganoSomaticIL4RMutations2018b?)
IRF4 1, aSHM (mottokIntegrativeGenomicAnalysis2019b?; Morin et al. 2011)
IRF8 1, aSHM (Panea et al. 2019; Morin et al. 2011; mottokIntegrativeGenomicAnalysis2019b?)
ITPKB 1, aSHM (schmitzGeneticsPathogenesisDiffuse2018a?; reichelFlowSortingExome2015a?)
KLF2 1, aSHM (Desch et al. 2020; Jallades et al. 2017; Pasqualucci et al. 2011)
KLHL14 1 (Zhang et al. 2013)
KLHL6 1, aSHM (Panea et al. 2019; Ganapathi et al. 2016; Morin et al. 2011)
KMT2C 1 (Zhang et al. 2014; sarkozyMutationalLandscapeGray2021a?; Zhou et al. 2019; Zhang et al. 2013)
KMT2D 1 (Desch et al. 2020; rossiCodingGenomeSplenic2012c?; Grande et al. 2019; Morin et al. 2011; Beà et al. 2013)
KRAS 1 (lohrDiscoveryPrioritizationSomatic2012a?)
LCOR 1 (Arthur et al. 2018)
LTB 1, aSHM (Desch et al. 2020; chapuyMolecularSubtypesDiffuse2018b?; Panea et al. 2019)
MEF2B 1, aSHM (Beà et al. 2013; Morin et al. 2011)
MEF2C 1, aSHM (Arthur et al. 2018)
MGA 1 (Jallades et al. 2017; Zhang et al. 2013)
MPEG1 1 (Morin et al. 2013)
MS4A1 1, aSHM (Rushton et al. 2020; mottokIntegrativeGenomicAnalysis2019b?)
MTOR 1 (Zhang et al. 2013; Panea et al. 2019)
MYC 1, aSHM (pasqualucciHypermutationMultipleProtooncogenes2001a?; Jallades et al. 2017; dunsCharacterizationDLBCLPMBL2021b?; Johnston and Carroll 1992)
MYD88 1 (yanBCRTLRSignaling2012a?; ngoOncogenicallyActiveMYD882011a?)
NFKBIA 1 (Lake et al. 2009; wienandGenomicAnalysesFlowsorted2019b?; russler-germainMutationsAssociatedProgression2023b?)
NFKBIE 1 (Morin et al. 2016; Pararajalingam et al. 2020; Mansouri et al. 2016)
NFKBIZ 1, noncoding (Morin et al. 2016)
NOL9 1, aSHM (spinaGeneticsNodalMarginal2016b?; schmitzGeneticsPathogenesisDiffuse2018a?)
NOTCH1 1 (Beà et al. 2013; Pasqualucci et al. 2011; Love et al. 2012; rossiCodingGenomeSplenic2012c?)
NOTCH2 1 (rossiCodingGenomeSplenic2012c?; Panea et al. 2019; Beà et al. 2013; Trøen et al. 2008)
OSBPL10 1, aSHM (Arthur et al. 2018)
P2RY8 1 (muppidiLossSignalingGa132014b?; lohrDiscoveryPrioritizationSomatic2012a?)
PIM1 1, aSHM (pasqualucciHypermutationMultipleProtooncogenes2001a?; dunsCharacterizationDLBCLPMBL2021b?; burkhardtClinicalRelevanceMolecular2022b?)
PIM2 1, aSHM (Arthur et al. 2018; reichelFlowSortingExome2015a?)
POU2AF1 1, aSHM (krysiakRecurrentSomaticMutations2017b?)
POU2F2 1 (krysiakRecurrentSomaticMutations2017b?; Zhang et al. 2013)
PRDM1 1 (pasqualucciInactivationPRDM1BLIMP12006a?)
PTEN 1 (Love et al. 2012)
PTPRD 1 (spinaGeneticsNodalMarginal2016b?)
RB1 1 (Zhang et al. 2014; Morin et al. 2013)
RFX7 1 (Grande et al. 2019)
RHOA 1 (richterRecurrentMutationID32012a?)
RRAGC 1 (okosunRecurrentMTORC1activatingRRAGC2016a?)
S1PR2 1, aSHM (Morin et al. 2011; muppidiLossSignalingGa132014b?)
SETD1B 1 (Reddy et al. 2017)
SF3B1 1 (Love et al. 2012)
SGK1 1, aSHM (dunsCharacterizationDLBCLPMBL2021b?; Morin et al. 2011)
SIN3A 1 (Grande et al. 2019; rossiCodingGenomeSplenic2012c?)
SMARCA4 1 (Zhang et al. 2013; nadeuGenomicEpigenomicInsights2020b?; krysiakRecurrentSomaticMutations2017b?; richterRecurrentMutationID32012a?)
SOCS1 1, aSHM (wenigerMutationsTumorSuppressor2006a?; Morin et al. 2011)
SPEN 1 (sarkozyMutationalLandscapeGray2021a?; rossiCodingGenomeSplenic2012c?)
STAT3 1 (Ohgami et al. 2014)
STAT6 1 (yildizActivatingSTAT6Mutations2015c?; ritzRecurrentMutationsSTAT62009a?)
TAF1 1 (spinaGeneticsNodalMarginal2016b?; Morin et al. 2013)
TBL1XR1 1 (rossiCodingGenomeSplenic2012c?; Mareschal et al. 2016)
TET2 1 (albuquerqueEnhancingKnowledgeDiscovery2017a?; Panea et al. 2019)
TMEM30A 1 (Morin et al. 2011)
TMSB4X 1, aSHM (albuquerqueEnhancingKnowledgeDiscovery2017a?)
TNFAIP3 1 (schmitzTNFAIP3A20Tumor2009a?; rossiAlterationBIRC3Multiple2011a?; compagnoMutationsMultipleGenes2009a?)
TNFRSF14 1 (cheungAcquiredTNFRSF14Mutations2010a?; spinaGeneticsNodalMarginal2016b?)
TOX 1 (Reddy et al. 2017)
TP53 1 (Wilda et al. 2004; rossiCodingGenomeSplenic2012c?; tiacciPervasiveMutationsJAKSTAT2018b?; Beà et al. 2013; Morin et al. 2011)
TRRAP 1 (rossiCodingGenomeSplenic2012c?; Parry et al. 2013)
UBE2A 1 (Reddy et al. 2017; reichelFlowSortingExome2015a?)
UNC5C 1
USP7 1 (Grande et al. 2019)
VPS13B 1
WEE1 1 (schmitzGeneticsPathogenesisDiffuse2018a?; reichelFlowSortingExome2015a?)
XPO1 1 (jardinRecurrentMutationsExportin2016a?; Mareschal et al. 2016)
ZC3H12A 1 (Arthur et al. 2018)
ZFP36L1 1, aSHM (Morin et al. 2011; reichelFlowSortingExome2015a?; Panea et al. 2019)
ZNF292 1 (Zhang et al. 2013)
ZNF608 1, aSHM (Zhang et al. 2013; krysiakRecurrentSomaticMutations2017b?)

Tier 2 DLBCL genes

198 total

Gene Tier Relevant references
ABI3BP 2 (Morin et al. 2013)
ADAMTS1 2 (hubschmannMutationalMechanismsShaping2021b?)
AICDA 2, aSHM (Arthur et al. 2018)
ANKRD12 2 (hubschmannMutationalMechanismsShaping2021b?)
ANKRD17 2 (Reddy et al. 2017)
ARID1B 2 (Reddy et al. 2017)
ARID5B 2 (Reddy et al. 2017; Gomez et al. 2023)
ATR 2 (Reddy et al. 2017)
BCL11A 2, aSHM
BCOR 2 (nadeuGenomicEpigenomicInsights2020b?; Jallades et al. 2017)
BCR 2, aSHM
BIRC3 2, aSHM (dunsCharacterizationDLBCLPMBL2021b?; rossiAlterationBIRC3Multiple2011a?; Arthur et al. 2018; Beà et al. 2013)
BLK 2, aSHM
BRINP3 2 (Reddy et al. 2017)
BTBD3 2 (Reddy et al. 2017)
CADPS2 2 (hubschmannMutationalMechanismsShaping2021b?)
CASP8 2 (Reddy et al. 2017)
CBLB 2 (Reddy et al. 2017)
CCL4 2 (chapuyMolecularSubtypesDiffuse2018b?)
CD22 2 (Reddy et al. 2017)
CD274 2 (Morin et al. 2011)
CD36 2 (Pasqualucci et al. 2011)
CD44 2, aSHM (Arthur et al. 2018)
CD74 2, aSHM (Arthur et al. 2018)
CDC73 2 (Reddy et al. 2017; Love et al. 2012)
CDH9 2 (Morin et al. 2013)
CHD1 2 (Reddy et al. 2017)
CHD8 2 (Grande et al. 2019; Reddy et al. 2017)
CHST2 2 (Reddy et al. 2017)
CNOT2 2 (hubschmannMutationalMechanismsShaping2021b?)
CNTNAP5 2 (Morin et al. 2013)
COQ7 2 (chapuyMolecularSubtypesDiffuse2018b?)
CRIP1 2 (chapuyMolecularSubtypesDiffuse2018b?)
DAZAP1 2 (Pararajalingam et al. 2020)
DCAF6 2 (Reddy et al. 2017)
DDX10 2 (Reddy et al. 2017)
DHX16 2 (hubschmannMutationalMechanismsShaping2021b?)
DICER1 2 (Reddy et al. 2017)
DNAH5 2 (Morin et al. 2013; Jallades et al. 2017)
DNM2 2 (hubschmannMutationalMechanismsShaping2021b?)
DNMT3A 2 (Reddy et al. 2017)
DOCK1 2 (chapuyMolecularSubtypesDiffuse2018b?)
DSG4 2 (Morin et al. 2013)
EIF2AK3 2, aSHM
EZR 2, aSHM (Desch et al. 2020)
FAM102A 2, aSHM
FAM38B 2 (Morin et al. 2013)
FANK1 2, aSHM
FAT4 2 (Parry et al. 2013; Morin et al. 2013; Zhang et al. 2014)
FCRL3 2, aSHM
FNBP1 2, aSHM
FNDC1 2 (Morin et al. 2013)
FOXC1 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
FOXP1 2, aSHM (Reddy et al. 2017)
FUBP1 2 (Reddy et al. 2017)
FUT5 2 (chapuyMolecularSubtypesDiffuse2018b?)
GABRA2 2 (chapuyMolecularSubtypesDiffuse2018b?)
GAK 2 (hubschmannMutationalMechanismsShaping2021b?)
GNAS 2 (Reddy et al. 2017)
GOLGA5 2 (Reddy et al. 2017)
GPC5 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
GSG2 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
HDAC7 2 (Morin et al. 2013)
HIST1H2AG 2, aSHM (Morin et al. 2013; rossiCodingGenomeSplenic2012c?; Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?)
HLA-DMA 2
HLA-DQA1 2 (hubschmannMutationalMechanismsShaping2021b?)
HNF1B 2 (Pasqualucci et al. 2011)
HNRNPD 2
HNRNPH1 2, noncoding (Pararajalingam et al. 2020)
HRAS 2 (Jallades et al. 2017; Reddy et al. 2017)
ID3 2 (richterRecurrentMutationID32012a?; spinaGeneticsNodalMarginal2016b?; Schmitz et al. 2012)
IER2 2 (Morin et al. 2013)
IFNGR1 2 (Morin et al. 2013)
IGLL5 2, aSHM (russler-germainMutationsAssociatedProgression2023b?; Desch et al. 2020; Panea et al. 2019)
IKBKB 2 (Reddy et al. 2017; rossiAlterationBIRC3Multiple2011a?; wienandGenomicAnalysesFlowsorted2019b?)
IKBKE 2 (hubschmannMutationalMechanismsShaping2021b?)
IL16 2
IL6 2 (chapuyMolecularSubtypesDiffuse2018b?)
INO80 2 (Zhang et al. 2013)
IRAG2 2, aSHM
IRF1 2, aSHM (hubschmannMutationalMechanismsShaping2021b?)
JAK1 2 (Zhang et al. 2013; mottokIntegrativeGenomicAnalysis2019b?)
JAK3 2 (Zhang et al. 2013)
JUNB 2 (Reddy et al. 2017; mottokIntegrativeGenomicAnalysis2019b?)
KCMF1 2 (Reddy et al. 2017)
KLHL21 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
LAMA5 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
LAPTM5 2, aSHM (hubschmannMutationalMechanismsShaping2021b?)
LIN54 2 (Reddy et al. 2017)
LPP 2, aSHM (Arthur et al. 2018)
LRP12 2 (hubschmannMutationalMechanismsShaping2021b?)
LRRN3 2 (sarkozyMutationalLandscapeGray2021a?; Morin et al. 2013)
LYN 2 (chapuyMolecularSubtypesDiffuse2018b?)
MAGT1 2 (Reddy et al. 2017)
MALAT1 2, aSHM (Arthur et al. 2018)
MAP2K1 2 (Shin et al. 2015; louissaintPediatrictypeNodalFollicular2016a?)
MAP4K4 2 (Reddy et al. 2017)
MARK1 2 (Reddy et al. 2017)
MCL1 2 (Panea et al. 2019; Reddy et al. 2017; dunsCharacterizationDLBCLPMBL2021b?)
MECOM 2 (Reddy et al. 2017)
MET 2 (Reddy et al. 2017)
MIR142 2, aSHM (Grande et al. 2019; kwanhianMicroRNA142Mutated202012b?)
MIR155HG 2, aSHM
MPDZ 2 (reichelFlowSortingExome2015a?; Morin et al. 2013)
MSH2 2 (Reddy et al. 2017)
MSH6 2 (Reddy et al. 2017)
MYB 2 (Reddy et al. 2017; Desch et al. 2020)
MYBPC2 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
MYO1E 2, aSHM
MYOM2 2 (Pasqualucci et al. 2011)
N2RF2 2 (hubschmannMutationalMechanismsShaping2021b?)
NANOG 2 (chapuyMolecularSubtypesDiffuse2018b?)
NAV1 2 (chapuyMolecularSubtypesDiffuse2018b?)
NCOA3 2, aSHM
NCOR1 2 (Reddy et al. 2017)
NCOR2 2 (Schmitz et al. 2012; spinaGeneticsNodalMarginal2016b?; sarkozyMutationalLandscapeGray2021a?)
NEAT1 2, aSHM (Arthur et al. 2018)
NF1 2 (Reddy et al. 2017)
NFKB1 2
NFKB2 2 (Reddy et al. 2017; mottokIntegrativeGenomicAnalysis2019b?)
NLRC5 2
NLRP5 2 (Morin et al. 2013)
NLRP8 2 (chapuyMolecularSubtypesDiffuse2018b?)
ODZ3 2 (Morin et al. 2013)
P2RX5 2, aSHM (Morin et al. 2013)
PAPOLG 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
PASK 2 (Morin et al. 2013)
PAX5 2, aSHM (pasqualucciHypermutationMultipleProtooncogenes2001a?)
PCBP1 2 (Schmitz et al. 2012)
PCDHB11 2 (Morin et al. 2013)
PCLO 2 (lohrDiscoveryPrioritizationSomatic2012a?)
PDE4DIP 2 (chapuyMolecularSubtypesDiffuse2018b?)
PDS5B 2 (hubschmannMutationalMechanismsShaping2021b?; Morin et al. 2013)
PHF6 2 (Reddy et al. 2017; Thomas et al. 2023)
PIK3CD 2 (Reddy et al. 2017)
PIK3R1 2 (Zhang et al. 2013; Panea et al. 2019)
PKD1 2 (Morin et al. 2013)
PNPO 2 (hubschmannMutationalMechanismsShaping2021b?)
POGZ 2 (Morin et al. 2013)
PPP1R9B 2
PRKCB 2 (Morin et al. 2013)
PRKDC 2 (hubschmannMutationalMechanismsShaping2021b?; schmitzGeneticsPathogenesisDiffuse2018a?)
PRPS1 2 (chapuyMolecularSubtypesDiffuse2018b?)
PTMA 2, aSHM
PTPN1 2, aSHM (gunawardanaRecurrentSomaticMutations2014c?)
PTPN23 2 (Morin et al. 2013)
PTPN6 2 (Reddy et al. 2017)
PTPRK 2 (Reddy et al. 2017)
RAC2 2 (hubschmannMutationalMechanismsShaping2021b?; Panea et al. 2019)
RAD9A 2 (chapuyMolecularSubtypesDiffuse2018b?)
RARA 2 (Reddy et al. 2017)
RCC 2, aSHM
RFTN1 2, aSHM (dunsCharacterizationDLBCLPMBL2021b?; Arthur et al. 2018)
RFXAP 2
RHEX 2, aSHM
RHOH 2, aSHM (pasqualucciHypermutationMultipleProtooncogenes2001a?)
RUBCNL 2, aSHM
RUNX1 2 (Reddy et al. 2017)
SAMD9L 2 (Morin et al. 2013)
SARM1 2 (Morin et al. 2013)
SEL1L3 2, aSHM
SEPTIN9 2, aSHM
SERPINA9 2, aSHM (Arthur et al. 2018)
SETD2 2 (Zhang et al. 2013)
SETD5 2 (Reddy et al. 2017; tiacciPervasiveMutationsJAKSTAT2018b?)
SIAH2 2 (reichelFlowSortingExome2015a?; hubschmannMutationalMechanismsShaping2021b?)
SLC34A2 2 (hubschmannMutationalMechanismsShaping2021b?)
SMEK1 2 (chapuyMolecularSubtypesDiffuse2018b?)
SRRM2 2 (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2013)
ST6GAL1 2, aSHM (Arthur et al. 2018)
STAT5B 2 (Zhang et al. 2013; tiacciPervasiveMutationsJAKSTAT2018b?)
SYK 2 (Reddy et al. 2017)
SYPL1 2 (Morin et al. 2013)
TAP1 2 (schmitzGeneticsPathogenesisDiffuse2018a?)
TBC1D4 2, aSHM (Arthur et al. 2018)
TCL1A 2, aSHM (Grande et al. 2019)
TGFBR2 2 (Reddy et al. 2017)
TIPARP 2 (Reddy et al. 2017)
TLR2 2 (chapuyMolecularSubtypesDiffuse2018b?; Beà et al. 2013)
TRAF3 2 (rossiAlterationBIRC3Multiple2011a?; ottoGeneticLesionsTRAF32012a?; Pasqualucci et al. 2011)
TRAF6 2 (hubschmannMutationalMechanismsShaping2021b?)
TRIP12 2
UBE2J1 2, aSHM
UBR5 2 (Pararajalingam et al. 2020; Zhang et al. 2013)
UNC5B 2 (hubschmannMutationalMechanismsShaping2021b?)
UNC5D 2
WAC 2 (rossiCodingGenomeSplenic2012c?; Reddy et al. 2017)
WDFY3 2 (Morin et al. 2013)
WNK1 2 (hubschmannMutationalMechanismsShaping2021b?; Thomas et al. 2023; Jallades et al. 2017)
XBP1 2, aSHM
YY1 2 (Reddy et al. 2017)
ZBTB7A 2 (burkhardtClinicalRelevanceMolecular2022b?; Reddy et al. 2017)
ZCCHC7 2, aSHM (Arthur et al. 2018)
ZEB2 2 (Zhang et al. 2013)
ZFAT 2 (Reddy et al. 2017)
ZFX 2 (Reddy et al. 2017)
ZNF217 2 (hubschmannMutationalMechanismsShaping2021b?; reichelFlowSortingExome2015a?)
ZNF423 2 (chapuyMolecularSubtypesDiffuse2018b?)

References

Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 (45): 18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (Ebf1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified Common and Disease-Specific Abnormalities.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 25 (5): 651–60. https://doi.org/10.1038/modpathol.2011.213.
Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020. “Genotyping Circulating Tumor DNA of Pediatric Hodgkin Lymphoma.” Leukemia 34 (1): 151–66. https://doi.org/10.1038/s41375-019-0541-6.
Ganapathi, Karthik A., Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain, Jinli Chen, Luciano Cascione, Odelia Nahum, et al. 2016. “The Genetic Landscape of Dural Marginal Zone Lymphomas.” Oncotarget 7 (28): 43052–61. https://doi.org/10.18632/oncotarget.9678.
Gomez, Felicia, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, et al. 2023. “Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.” Cancer Research Communications 3 (11): 2312–30. https://doi.org/10.1158/2767-9764.CRC-23-0140.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017. “Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of Klf2, Tnfaip3 and Myd88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica 102 (10): 1758–66. https://doi.org/10.3324/haematol.2016.160192.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic Card11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79. https://doi.org/10.1126/science.1153629.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent NFKBIE Deletions Are Associated with Poor Outcome in Primary Mediastinal B-cell Lymphoma.” Blood 128 (23): 2666–70. https://doi.org/10.1182/blood-2016-03-704528.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel A. Arber. 2014. Stat3 Mutations Are Present in Aggressive B-cell Lymphomas Including a Subset of Diffuse Large B-cell Lymphomas with Cd30 Expression.” Haematologica 99 (7): e105–107. https://doi.org/10.3324/haematol.2013.101543.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 (5): 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 (12): e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell 171 (2): 481–494.e15.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/Cd95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. BRAF V600e and Map2k1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated Bcl2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37. https://doi.org/10.1182/blood.V79.1.229.229.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 (8): 904–16. https://doi.org/10.1182/blood.2022016534.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. Notch2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 (7): 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent Card11 Mutations.” Oncotarget 7 (25): 38180–90. https://doi.org/10.18632/oncotarget.9500.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110: 1398–1403. https://doi.org/10.1073/pnas.1205299110.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 (19): 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent Foxo1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 (14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.