DLBCL genes
Origins of DLBCL genes
Tier 1 DLBCL genes
128 total
| Gene | Tier | Relevant references |
|---|---|---|
| ACTB | 1, aSHM | (wienandGenomicAnalysesFlowsorted2019b?; lohrDiscoveryPrioritizationSomatic2012a?) |
| ACTG1 | 1, aSHM | (spinaGeneticsNodalMarginal2016b?; Desch et al. 2020; hubschmannMutationalMechanismsShaping2021b?) |
| ARID1A | 1 | (rossiCodingGenomeSplenic2012c?; wienandGenomicAnalysesFlowsorted2019b?; Love et al. 2012; Zhang et al. 2013; krysiakRecurrentSomaticMutations2017b?) |
| ATM | 1 | (Braggio et al. 2012; Beà et al. 2013; Reddy et al. 2017) |
| B2M | 1 | (Pararajalingam et al. 2020; reichelFlowSortingExome2015a?; Morin et al. 2011) |
| BCL10 | 1 | (Morin et al. 2011; russler-germainMutationsAssociatedProgression2023b?; spinaGeneticsNodalMarginal2016b?) |
| BCL2 | 1, aSHM | (sarkozyMutationalLandscapeGray2021a?; Tanaka et al. 1992; burkhardtClinicalRelevanceMolecular2022b?; Morin et al. 2011) |
| BCL6 | 1, aSHM | (Morin et al. 2011; Love et al. 2012) |
| BCL7A | 1, aSHM | (reichelFlowSortingExome2015a?; krysiakRecurrentSomaticMutations2017b?; Arthur et al. 2018; Grande et al. 2019) |
| BIRC6 | 1 | (Reddy et al. 2017; sarkozyMutationalLandscapeGray2021a?) |
| BRAF | 1 | (Love et al. 2012; tiacciBRAFMutationsHairycell2011a?) |
| BTG1 | 1, aSHM | (Morin et al. 2011; burkhardtClinicalRelevanceMolecular2022b?; sarkozyMutationalLandscapeGray2021a?) |
| BTG2 | 1, aSHM | (Morin et al. 2011; Love et al. 2012) |
| BTK | 1 | (krysiakRecurrentSomaticMutations2017b?; albuquerqueEnhancingKnowledgeDiscovery2017a?) |
| CARD11 | 1 | (Wu et al. 2016; Panea et al. 2019; Lenz et al. 2008; yanBCRTLRSignaling2012a?; Morin et al. 2011) |
| CCND3 | 1 | (Jallades et al. 2017; richterRecurrentMutationID32012a?; Desch et al. 2020; Morin et al. 2011) |
| CD58 | 1 | (Morin et al. 2011; schneiderAlterationsCD58Gene2015a?) |
| CD70 | 1 | (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2011) |
| CD79B | 1 | (Morin et al. 2011; Panea et al. 2019) |
| CD83 | 1, aSHM | (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2013; dunsCharacterizationDLBCLPMBL2021b?; Panea et al. 2019) |
| CDKN2A | 1 | (Grande et al. 2019; spinaGeneticsNodalMarginal2016b?; Morin et al. 2013) |
| CIITA | 1, aSHM | (mottokGenomicAlterationsCIITA2015b?; Morin et al. 2011) |
| CREBBP | 1 | (dunsCharacterizationDLBCLPMBL2021b?; pasqualucciInactivatingMutationsAcetyltransferase2011a?; Love et al. 2012; Parry et al. 2013) |
| CXCR4 | 1, aSHM | (Khodabakhshi et al. 2012; Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?) |
| CXCR5 | 1 | (schmitzGeneticsPathogenesisDiffuse2018a?; mottokIntegrativeGenomicAnalysis2019b?) |
| DDX3X | 1 | (Schmitz et al. 2012; mottokIntegrativeGenomicAnalysis2019b?; schmitzGeneticsPathogenesisDiffuse2018a?) |
| DTX1 | 1, aSHM | (Panea et al. 2019; Gomez et al. 2023; schmitzGeneticsPathogenesisDiffuse2018a?; rossiCodingGenomeSplenic2012c?) |
| DUSP2 | 1, aSHM | (dunsCharacterizationDLBCLPMBL2021b?; Morin et al. 2013) |
| EBF1 | 1, aSHM | (reichelFlowSortingExome2015a?; Bohle et al. 2013; Thomas et al. 2023) |
| EEF1A1 | 1 | (hubschmannMutationalMechanismsShaping2021b?; reichelFlowSortingExome2015a?) |
| EP300 | 1 | (rossiCodingGenomeSplenic2012c?; Panea et al. 2019; pasqualucciInactivatingMutationsAcetyltransferase2011a?) |
| ETS1 | 1, aSHM | (Panea et al. 2019; Morin et al. 2011) |
| ETV6 | 1, aSHM | (Arthur et al. 2018) |
| EZH2 | 1 | (morinSomaticMutationsAltering2010a?; mottokIntegrativeGenomicAnalysis2019b?; Love et al. 2012) |
| FAS | 1 | (Scholl et al. 2007; spinaGeneticsNodalMarginal2016b?) |
| FBXO11 | 1 | (richterRecurrentMutationID32012a?; hubschmannMutationalMechanismsShaping2021b?; Parry et al. 2013) |
| FBXW7 | 1 | (Zhang et al. 2013) |
| FOXO1 | 1 | (Schmitz et al. 2012; Morin et al. 2011; dunsCharacterizationDLBCLPMBL2021b?) |
| GNA13 | 1 | (Love et al. 2012; Morin et al. 2011; reichelFlowSortingExome2015a?) |
| GNAI2 | 1 | (Grande et al. 2019; Morin et al. 2013) |
| GRB2 | 1 | (Panea et al. 2019; Pasqualucci et al. 2011) |
| GRHPR | 1, aSHM | (Arthur et al. 2018) |
| HIST1H1B | 1, aSHM | (krysiakRecurrentSomaticMutations2017b?; sarkozyMutationalLandscapeGray2021a?; chapuyMolecularSubtypesDiffuse2018b?) |
| HIST1H1C | 1, aSHM | (Morin et al. 2011; Panea et al. 2019) |
| HIST1H1D | 1, aSHM | (krysiakRecurrentSomaticMutations2017b?; Jallades et al. 2017; Morin et al. 2013) |
| HIST1H1E | 1, aSHM | (Morin et al. 2013; reichelFlowSortingExome2015a?; Grande et al. 2019; krysiakRecurrentSomaticMutations2017b?) |
| HIST1H2AC | 1, aSHM | (krysiakRecurrentSomaticMutations2017b?; Morin et al. 2013) |
| HIST1H2AM | 1, aSHM | (Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?) |
| HIST1H2BC | 1, aSHM | (krysiakRecurrentSomaticMutations2017b?; mottokIntegrativeGenomicAnalysis2019b?; Reddy et al. 2017) |
| HIST1H2BK | 1, aSHM | (Panea et al. 2019; rossiCodingGenomeSplenic2012c?) |
| HIST1H3B | 1, aSHM | (Zhang et al. 2013; reichelFlowSortingExome2015a?) |
| HIST2H2BE | 1, aSHM | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| HLA-A | 1 | (Desch et al. 2020) |
| HLA-B | 1 | (wienandGenomicAnalysesFlowsorted2019b?) |
| HLA-C | 1 | (Gomez et al. 2023) |
| HLA-DMB | 1 | |
| HNRNPU | 1, aSHM | (Panea et al. 2019; Reddy et al. 2017) |
| HVCN1 | 1 | (krysiakRecurrentSomaticMutations2017b?) |
| IKZF3 | 1 | (Morin et al. 2013; Panea et al. 2019) |
| IL4R | 1, aSHM | (dunsCharacterizationDLBCLPMBL2021b?; viganoSomaticIL4RMutations2018b?) |
| IRF4 | 1, aSHM | (mottokIntegrativeGenomicAnalysis2019b?; Morin et al. 2011) |
| IRF8 | 1, aSHM | (Panea et al. 2019; Morin et al. 2011; mottokIntegrativeGenomicAnalysis2019b?) |
| ITPKB | 1, aSHM | (schmitzGeneticsPathogenesisDiffuse2018a?; reichelFlowSortingExome2015a?) |
| KLF2 | 1, aSHM | (Desch et al. 2020; Jallades et al. 2017; Pasqualucci et al. 2011) |
| KLHL14 | 1 | (Zhang et al. 2013) |
| KLHL6 | 1, aSHM | (Panea et al. 2019; Ganapathi et al. 2016; Morin et al. 2011) |
| KMT2C | 1 | (Zhang et al. 2014; sarkozyMutationalLandscapeGray2021a?; Zhou et al. 2019; Zhang et al. 2013) |
| KMT2D | 1 | (Desch et al. 2020; rossiCodingGenomeSplenic2012c?; Grande et al. 2019; Morin et al. 2011; Beà et al. 2013) |
| KRAS | 1 | (lohrDiscoveryPrioritizationSomatic2012a?) |
| LCOR | 1 | (Arthur et al. 2018) |
| LTB | 1, aSHM | (Desch et al. 2020; chapuyMolecularSubtypesDiffuse2018b?; Panea et al. 2019) |
| MEF2B | 1, aSHM | (Beà et al. 2013; Morin et al. 2011) |
| MEF2C | 1, aSHM | (Arthur et al. 2018) |
| MGA | 1 | (Jallades et al. 2017; Zhang et al. 2013) |
| MPEG1 | 1 | (Morin et al. 2013) |
| MS4A1 | 1, aSHM | (Rushton et al. 2020; mottokIntegrativeGenomicAnalysis2019b?) |
| MTOR | 1 | (Zhang et al. 2013; Panea et al. 2019) |
| MYC | 1, aSHM | (pasqualucciHypermutationMultipleProtooncogenes2001a?; Jallades et al. 2017; dunsCharacterizationDLBCLPMBL2021b?; Johnston and Carroll 1992) |
| MYD88 | 1 | (yanBCRTLRSignaling2012a?; ngoOncogenicallyActiveMYD882011a?) |
| NFKBIA | 1 | (Lake et al. 2009; wienandGenomicAnalysesFlowsorted2019b?; russler-germainMutationsAssociatedProgression2023b?) |
| NFKBIE | 1 | (Morin et al. 2016; Pararajalingam et al. 2020; Mansouri et al. 2016) |
| NFKBIZ | 1, noncoding | (Morin et al. 2016) |
| NOL9 | 1, aSHM | (spinaGeneticsNodalMarginal2016b?; schmitzGeneticsPathogenesisDiffuse2018a?) |
| NOTCH1 | 1 | (Beà et al. 2013; Pasqualucci et al. 2011; Love et al. 2012; rossiCodingGenomeSplenic2012c?) |
| NOTCH2 | 1 | (rossiCodingGenomeSplenic2012c?; Panea et al. 2019; Beà et al. 2013; Trøen et al. 2008) |
| OSBPL10 | 1, aSHM | (Arthur et al. 2018) |
| P2RY8 | 1 | (muppidiLossSignalingGa132014b?; lohrDiscoveryPrioritizationSomatic2012a?) |
| PIM1 | 1, aSHM | (pasqualucciHypermutationMultipleProtooncogenes2001a?; dunsCharacterizationDLBCLPMBL2021b?; burkhardtClinicalRelevanceMolecular2022b?) |
| PIM2 | 1, aSHM | (Arthur et al. 2018; reichelFlowSortingExome2015a?) |
| POU2AF1 | 1, aSHM | (krysiakRecurrentSomaticMutations2017b?) |
| POU2F2 | 1 | (krysiakRecurrentSomaticMutations2017b?; Zhang et al. 2013) |
| PRDM1 | 1 | (pasqualucciInactivationPRDM1BLIMP12006a?) |
| PTEN | 1 | (Love et al. 2012) |
| PTPRD | 1 | (spinaGeneticsNodalMarginal2016b?) |
| RB1 | 1 | (Zhang et al. 2014; Morin et al. 2013) |
| RFX7 | 1 | (Grande et al. 2019) |
| RHOA | 1 | (richterRecurrentMutationID32012a?) |
| RRAGC | 1 | (okosunRecurrentMTORC1activatingRRAGC2016a?) |
| S1PR2 | 1, aSHM | (Morin et al. 2011; muppidiLossSignalingGa132014b?) |
| SETD1B | 1 | (Reddy et al. 2017) |
| SF3B1 | 1 | (Love et al. 2012) |
| SGK1 | 1, aSHM | (dunsCharacterizationDLBCLPMBL2021b?; Morin et al. 2011) |
| SIN3A | 1 | (Grande et al. 2019; rossiCodingGenomeSplenic2012c?) |
| SMARCA4 | 1 | (Zhang et al. 2013; nadeuGenomicEpigenomicInsights2020b?; krysiakRecurrentSomaticMutations2017b?; richterRecurrentMutationID32012a?) |
| SOCS1 | 1, aSHM | (wenigerMutationsTumorSuppressor2006a?; Morin et al. 2011) |
| SPEN | 1 | (sarkozyMutationalLandscapeGray2021a?; rossiCodingGenomeSplenic2012c?) |
| STAT3 | 1 | (Ohgami et al. 2014) |
| STAT6 | 1 | (yildizActivatingSTAT6Mutations2015c?; ritzRecurrentMutationsSTAT62009a?) |
| TAF1 | 1 | (spinaGeneticsNodalMarginal2016b?; Morin et al. 2013) |
| TBL1XR1 | 1 | (rossiCodingGenomeSplenic2012c?; Mareschal et al. 2016) |
| TET2 | 1 | (albuquerqueEnhancingKnowledgeDiscovery2017a?; Panea et al. 2019) |
| TMEM30A | 1 | (Morin et al. 2011) |
| TMSB4X | 1, aSHM | (albuquerqueEnhancingKnowledgeDiscovery2017a?) |
| TNFAIP3 | 1 | (schmitzTNFAIP3A20Tumor2009a?; rossiAlterationBIRC3Multiple2011a?; compagnoMutationsMultipleGenes2009a?) |
| TNFRSF14 | 1 | (cheungAcquiredTNFRSF14Mutations2010a?; spinaGeneticsNodalMarginal2016b?) |
| TOX | 1 | (Reddy et al. 2017) |
| TP53 | 1 | (Wilda et al. 2004; rossiCodingGenomeSplenic2012c?; tiacciPervasiveMutationsJAKSTAT2018b?; Beà et al. 2013; Morin et al. 2011) |
| TRRAP | 1 | (rossiCodingGenomeSplenic2012c?; Parry et al. 2013) |
| UBE2A | 1 | (Reddy et al. 2017; reichelFlowSortingExome2015a?) |
| UNC5C | 1 | |
| USP7 | 1 | (Grande et al. 2019) |
| VPS13B | 1 | |
| WEE1 | 1 | (schmitzGeneticsPathogenesisDiffuse2018a?; reichelFlowSortingExome2015a?) |
| XPO1 | 1 | (jardinRecurrentMutationsExportin2016a?; Mareschal et al. 2016) |
| ZC3H12A | 1 | (Arthur et al. 2018) |
| ZFP36L1 | 1, aSHM | (Morin et al. 2011; reichelFlowSortingExome2015a?; Panea et al. 2019) |
| ZNF292 | 1 | (Zhang et al. 2013) |
| ZNF608 | 1, aSHM | (Zhang et al. 2013; krysiakRecurrentSomaticMutations2017b?) |
Tier 2 DLBCL genes
198 total
| Gene | Tier | Relevant references |
|---|---|---|
| ABI3BP | 2 | (Morin et al. 2013) |
| ADAMTS1 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| AICDA | 2, aSHM | (Arthur et al. 2018) |
| ANKRD12 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| ANKRD17 | 2 | (Reddy et al. 2017) |
| ARID1B | 2 | (Reddy et al. 2017) |
| ARID5B | 2 | (Reddy et al. 2017; Gomez et al. 2023) |
| ATR | 2 | (Reddy et al. 2017) |
| BCL11A | 2, aSHM | |
| BCOR | 2 | (nadeuGenomicEpigenomicInsights2020b?; Jallades et al. 2017) |
| BCR | 2, aSHM | |
| BIRC3 | 2, aSHM | (dunsCharacterizationDLBCLPMBL2021b?; rossiAlterationBIRC3Multiple2011a?; Arthur et al. 2018; Beà et al. 2013) |
| BLK | 2, aSHM | |
| BRINP3 | 2 | (Reddy et al. 2017) |
| BTBD3 | 2 | (Reddy et al. 2017) |
| CADPS2 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| CASP8 | 2 | (Reddy et al. 2017) |
| CBLB | 2 | (Reddy et al. 2017) |
| CCL4 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| CD22 | 2 | (Reddy et al. 2017) |
| CD274 | 2 | (Morin et al. 2011) |
| CD36 | 2 | (Pasqualucci et al. 2011) |
| CD44 | 2, aSHM | (Arthur et al. 2018) |
| CD74 | 2, aSHM | (Arthur et al. 2018) |
| CDC73 | 2 | (Reddy et al. 2017; Love et al. 2012) |
| CDH9 | 2 | (Morin et al. 2013) |
| CHD1 | 2 | (Reddy et al. 2017) |
| CHD8 | 2 | (Grande et al. 2019; Reddy et al. 2017) |
| CHST2 | 2 | (Reddy et al. 2017) |
| CNOT2 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| CNTNAP5 | 2 | (Morin et al. 2013) |
| COQ7 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| CRIP1 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| DAZAP1 | 2 | (Pararajalingam et al. 2020) |
| DCAF6 | 2 | (Reddy et al. 2017) |
| DDX10 | 2 | (Reddy et al. 2017) |
| DHX16 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| DICER1 | 2 | (Reddy et al. 2017) |
| DNAH5 | 2 | (Morin et al. 2013; Jallades et al. 2017) |
| DNM2 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| DNMT3A | 2 | (Reddy et al. 2017) |
| DOCK1 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| DSG4 | 2 | (Morin et al. 2013) |
| EIF2AK3 | 2, aSHM | |
| EZR | 2, aSHM | (Desch et al. 2020) |
| FAM102A | 2, aSHM | |
| FAM38B | 2 | (Morin et al. 2013) |
| FANK1 | 2, aSHM | |
| FAT4 | 2 | (Parry et al. 2013; Morin et al. 2013; Zhang et al. 2014) |
| FCRL3 | 2, aSHM | |
| FNBP1 | 2, aSHM | |
| FNDC1 | 2 | (Morin et al. 2013) |
| FOXC1 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| FOXP1 | 2, aSHM | (Reddy et al. 2017) |
| FUBP1 | 2 | (Reddy et al. 2017) |
| FUT5 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| GABRA2 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| GAK | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| GNAS | 2 | (Reddy et al. 2017) |
| GOLGA5 | 2 | (Reddy et al. 2017) |
| GPC5 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| GSG2 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| HDAC7 | 2 | (Morin et al. 2013) |
| HIST1H2AG | 2, aSHM | (Morin et al. 2013; rossiCodingGenomeSplenic2012c?; Panea et al. 2019; krysiakRecurrentSomaticMutations2017b?) |
| HLA-DMA | 2 | |
| HLA-DQA1 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| HNF1B | 2 | (Pasqualucci et al. 2011) |
| HNRNPD | 2 | |
| HNRNPH1 | 2, noncoding | (Pararajalingam et al. 2020) |
| HRAS | 2 | (Jallades et al. 2017; Reddy et al. 2017) |
| ID3 | 2 | (richterRecurrentMutationID32012a?; spinaGeneticsNodalMarginal2016b?; Schmitz et al. 2012) |
| IER2 | 2 | (Morin et al. 2013) |
| IFNGR1 | 2 | (Morin et al. 2013) |
| IGLL5 | 2, aSHM | (russler-germainMutationsAssociatedProgression2023b?; Desch et al. 2020; Panea et al. 2019) |
| IKBKB | 2 | (Reddy et al. 2017; rossiAlterationBIRC3Multiple2011a?; wienandGenomicAnalysesFlowsorted2019b?) |
| IKBKE | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| IL16 | 2 | |
| IL6 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| INO80 | 2 | (Zhang et al. 2013) |
| IRAG2 | 2, aSHM | |
| IRF1 | 2, aSHM | (hubschmannMutationalMechanismsShaping2021b?) |
| JAK1 | 2 | (Zhang et al. 2013; mottokIntegrativeGenomicAnalysis2019b?) |
| JAK3 | 2 | (Zhang et al. 2013) |
| JUNB | 2 | (Reddy et al. 2017; mottokIntegrativeGenomicAnalysis2019b?) |
| KCMF1 | 2 | (Reddy et al. 2017) |
| KLHL21 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| LAMA5 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| LAPTM5 | 2, aSHM | (hubschmannMutationalMechanismsShaping2021b?) |
| LIN54 | 2 | (Reddy et al. 2017) |
| LPP | 2, aSHM | (Arthur et al. 2018) |
| LRP12 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| LRRN3 | 2 | (sarkozyMutationalLandscapeGray2021a?; Morin et al. 2013) |
| LYN | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| MAGT1 | 2 | (Reddy et al. 2017) |
| MALAT1 | 2, aSHM | (Arthur et al. 2018) |
| MAP2K1 | 2 | (Shin et al. 2015; louissaintPediatrictypeNodalFollicular2016a?) |
| MAP4K4 | 2 | (Reddy et al. 2017) |
| MARK1 | 2 | (Reddy et al. 2017) |
| MCL1 | 2 | (Panea et al. 2019; Reddy et al. 2017; dunsCharacterizationDLBCLPMBL2021b?) |
| MECOM | 2 | (Reddy et al. 2017) |
| MET | 2 | (Reddy et al. 2017) |
| MIR142 | 2, aSHM | (Grande et al. 2019; kwanhianMicroRNA142Mutated202012b?) |
| MIR155HG | 2, aSHM | |
| MPDZ | 2 | (reichelFlowSortingExome2015a?; Morin et al. 2013) |
| MSH2 | 2 | (Reddy et al. 2017) |
| MSH6 | 2 | (Reddy et al. 2017) |
| MYB | 2 | (Reddy et al. 2017; Desch et al. 2020) |
| MYBPC2 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| MYO1E | 2, aSHM | |
| MYOM2 | 2 | (Pasqualucci et al. 2011) |
| N2RF2 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| NANOG | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| NAV1 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| NCOA3 | 2, aSHM | |
| NCOR1 | 2 | (Reddy et al. 2017) |
| NCOR2 | 2 | (Schmitz et al. 2012; spinaGeneticsNodalMarginal2016b?; sarkozyMutationalLandscapeGray2021a?) |
| NEAT1 | 2, aSHM | (Arthur et al. 2018) |
| NF1 | 2 | (Reddy et al. 2017) |
| NFKB1 | 2 | |
| NFKB2 | 2 | (Reddy et al. 2017; mottokIntegrativeGenomicAnalysis2019b?) |
| NLRC5 | 2 | |
| NLRP5 | 2 | (Morin et al. 2013) |
| NLRP8 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| ODZ3 | 2 | (Morin et al. 2013) |
| P2RX5 | 2, aSHM | (Morin et al. 2013) |
| PAPOLG | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| PASK | 2 | (Morin et al. 2013) |
| PAX5 | 2, aSHM | (pasqualucciHypermutationMultipleProtooncogenes2001a?) |
| PCBP1 | 2 | (Schmitz et al. 2012) |
| PCDHB11 | 2 | (Morin et al. 2013) |
| PCLO | 2 | (lohrDiscoveryPrioritizationSomatic2012a?) |
| PDE4DIP | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| PDS5B | 2 | (hubschmannMutationalMechanismsShaping2021b?; Morin et al. 2013) |
| PHF6 | 2 | (Reddy et al. 2017; Thomas et al. 2023) |
| PIK3CD | 2 | (Reddy et al. 2017) |
| PIK3R1 | 2 | (Zhang et al. 2013; Panea et al. 2019) |
| PKD1 | 2 | (Morin et al. 2013) |
| PNPO | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| POGZ | 2 | (Morin et al. 2013) |
| PPP1R9B | 2 | |
| PRKCB | 2 | (Morin et al. 2013) |
| PRKDC | 2 | (hubschmannMutationalMechanismsShaping2021b?; schmitzGeneticsPathogenesisDiffuse2018a?) |
| PRPS1 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| PTMA | 2, aSHM | |
| PTPN1 | 2, aSHM | (gunawardanaRecurrentSomaticMutations2014c?) |
| PTPN23 | 2 | (Morin et al. 2013) |
| PTPN6 | 2 | (Reddy et al. 2017) |
| PTPRK | 2 | (Reddy et al. 2017) |
| RAC2 | 2 | (hubschmannMutationalMechanismsShaping2021b?; Panea et al. 2019) |
| RAD9A | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| RARA | 2 | (Reddy et al. 2017) |
| RCC | 2, aSHM | |
| RFTN1 | 2, aSHM | (dunsCharacterizationDLBCLPMBL2021b?; Arthur et al. 2018) |
| RFXAP | 2 | |
| RHEX | 2, aSHM | |
| RHOH | 2, aSHM | (pasqualucciHypermutationMultipleProtooncogenes2001a?) |
| RUBCNL | 2, aSHM | |
| RUNX1 | 2 | (Reddy et al. 2017) |
| SAMD9L | 2 | (Morin et al. 2013) |
| SARM1 | 2 | (Morin et al. 2013) |
| SEL1L3 | 2, aSHM | |
| SEPTIN9 | 2, aSHM | |
| SERPINA9 | 2, aSHM | (Arthur et al. 2018) |
| SETD2 | 2 | (Zhang et al. 2013) |
| SETD5 | 2 | (Reddy et al. 2017; tiacciPervasiveMutationsJAKSTAT2018b?) |
| SIAH2 | 2 | (reichelFlowSortingExome2015a?; hubschmannMutationalMechanismsShaping2021b?) |
| SLC34A2 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| SMEK1 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
| SRRM2 | 2 | (russler-germainMutationsAssociatedProgression2023b?; Morin et al. 2013) |
| ST6GAL1 | 2, aSHM | (Arthur et al. 2018) |
| STAT5B | 2 | (Zhang et al. 2013; tiacciPervasiveMutationsJAKSTAT2018b?) |
| SYK | 2 | (Reddy et al. 2017) |
| SYPL1 | 2 | (Morin et al. 2013) |
| TAP1 | 2 | (schmitzGeneticsPathogenesisDiffuse2018a?) |
| TBC1D4 | 2, aSHM | (Arthur et al. 2018) |
| TCL1A | 2, aSHM | (Grande et al. 2019) |
| TGFBR2 | 2 | (Reddy et al. 2017) |
| TIPARP | 2 | (Reddy et al. 2017) |
| TLR2 | 2 | (chapuyMolecularSubtypesDiffuse2018b?; Beà et al. 2013) |
| TRAF3 | 2 | (rossiAlterationBIRC3Multiple2011a?; ottoGeneticLesionsTRAF32012a?; Pasqualucci et al. 2011) |
| TRAF6 | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| TRIP12 | 2 | |
| UBE2J1 | 2, aSHM | |
| UBR5 | 2 | (Pararajalingam et al. 2020; Zhang et al. 2013) |
| UNC5B | 2 | (hubschmannMutationalMechanismsShaping2021b?) |
| UNC5D | 2 | |
| WAC | 2 | (rossiCodingGenomeSplenic2012c?; Reddy et al. 2017) |
| WDFY3 | 2 | (Morin et al. 2013) |
| WNK1 | 2 | (hubschmannMutationalMechanismsShaping2021b?; Thomas et al. 2023; Jallades et al. 2017) |
| XBP1 | 2, aSHM | |
| YY1 | 2 | (Reddy et al. 2017) |
| ZBTB7A | 2 | (burkhardtClinicalRelevanceMolecular2022b?; Reddy et al. 2017) |
| ZCCHC7 | 2, aSHM | (Arthur et al. 2018) |
| ZEB2 | 2 | (Zhang et al. 2013) |
| ZFAT | 2 | (Reddy et al. 2017) |
| ZFX | 2 | (Reddy et al. 2017) |
| ZNF217 | 2 | (hubschmannMutationalMechanismsShaping2021b?; reichelFlowSortingExome2015a?) |
| ZNF423 | 2 | (chapuyMolecularSubtypesDiffuse2018b?) |
References
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan
Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018.
“Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse
Large B-cell Lymphoma.” Nature
Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David
Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of
Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.”
Proceedings of the National Academy of Sciences 110 (45):
18250–55. https://doi.org/10.1073/pnas.1314608110.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role
of Early B-cell Factor 1 (Ebf1)
in Hodgkin Lymphoma.” Leukemia 27 (3):
671–79. https://doi.org/10.1038/leu.2012.280.
Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng
Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic
Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified
Common and Disease-Specific Abnormalities.” Modern Pathology:
An Official Journal of the United States and Canadian Academy of
Pathology, Inc 25 (5): 651–60. https://doi.org/10.1038/modpathol.2011.213.
Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil,
Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020.
“Genotyping Circulating Tumor DNA of Pediatric
Hodgkin Lymphoma.” Leukemia 34 (1): 151–66.
https://doi.org/10.1038/s41375-019-0541-6.
Ganapathi, Karthik A., Vaidehi Jobanputra, Fabio Iwamoto, Preti Jain,
Jinli Chen, Luciano Cascione, Odelia Nahum, et al. 2016. “The
Genetic Landscape of Dural Marginal Zone Lymphomas.”
Oncotarget 7 (28): 43052–61. https://doi.org/10.18632/oncotarget.9678.
Gomez, Felicia, Bryan Fisk, Joshua F. McMichael, Matthew Mosior,
Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, et al. 2023.
“Ultra-Deep Sequencing Reveals the Mutational
Landscape of Classical Hodgkin Lymphoma.”
Cancer Research Communications 3 (11): 2312–30. https://doi.org/10.1158/2767-9764.CRC-23-0140.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner,
Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019.
“Genome-Wide Discovery of Somatic Coding and Noncoding Mutations
in Pediatric Endemic and Sporadic Burkitt Lymphoma.”
Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour
Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017.
“Exome Sequencing Identifies Recurrent BCOR
Alterations and the Absence of Klf2, Tnfaip3
and Myd88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica
102 (10): 1758–66. https://doi.org/10.3324/haematol.2016.160192.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in
Burkitt’s Lymphoma.” Leukemia &
Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J.
Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et
al. 2012. “Recurrent
Targets of Aberrant Somatic Hypermutation in Lymphoma.”
Oncotarget 3 (11): 1308–19.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie
Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations
of NFKBIA, Encoding IkappaB Alpha, Are a
Recurrent Finding in Classical Hodgkin Lymphoma but Are Not
a Unifying Feature of Non-EBV-associated
Cases.” International Journal of Cancer 125 (6):
1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George,
George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic
Card11 Mutations in Human Diffuse Large B Cell
Lymphoma.” Science 319 (5870): 1676–79. https://doi.org/10.1126/science.1153629.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney
Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of
Mutations in Burkitt Lymphoma.” Nature
Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa
Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent
NFKBIE Deletions Are Associated with Poor Outcome in
Primary Mediastinal B-cell Lymphoma.”
Blood 128 (23): 2666–70. https://doi.org/10.1182/blood-2016-03-704528.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe
Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et
al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients
Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes
& Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri,
Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016.
“Genetic Landscapes of Relapsed and
Refractory Diffuse Large B-Cell Lymphomas.”
Clinical Cancer Research: An Official Journal of the American
Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya,
Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011.
“Frequent Mutation of Histone-Modifying Genes in
Non-Hodgkin Lymphoma.” Nature 476 (7360):
298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall,
Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013.
“Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome
Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel
A. Arber. 2014. “Stat3 Mutations Are Present in
Aggressive B-cell Lymphomas Including a
Subset of Diffuse Large B-cell Lymphomas
with Cd30 Expression.” Haematologica 99
(7): e105–107. https://doi.org/10.3324/haematol.2013.101543.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A.
Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of
Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole
Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020.
“Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified
Through Exome and Genome Sequencing.” Blood 136 (5):
572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis,
Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole
Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients
with Splenic Marginal Zone Lymphoma.” PloS One 8 (12):
e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide
Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011.
“Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics
43 (9): 830–37. https://doi.org/10.1038/ng.892.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt,
Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and
Functional Drivers of Diffuse Large B Cell
Lymphoma.” Cell 171 (2): 481–494.e15.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew
Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al.
2020. “Genetic and Evolutionary Patterns of Treatment Resistance
in Relapsed B-cell Lymphoma.”
Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar,
Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt
Lymphoma Pathogenesis and Therapeutic Targets from Structural and
Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector,
and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region
of FAS/Cd95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia &
Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won
Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF
V600e and Map2k1 Mutations in Hairy Cell Leukemia
and Splenic Marginal Zone Lymphoma Cases.” Annals of
Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992.
“Frequent Incidence of Somatic Mutations in Translocated
Bcl2 Oncogenes of Non-Hodgkin’s
Lymphomas.” Blood 79 (1): 229–37. https://doi.org/10.1182/blood.V79.1.229.229.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton,
Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023.
“Genetic Subgroups Inform on Pathobiology in Adult and Pediatric
Burkitt Lymphoma.” Blood 141 (8): 904–16.
https://doi.org/10.1182/blood.2022016534.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández
Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008.
“Notch2 Mutations in Marginal Zone Lymphoma.”
Haematologica 93 (7): 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and
W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic
Burkitt’s Lymphoma in Children.” Leukemia
18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry
Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016.
“Genetic Heterogeneity in Primary and Relapsed Mantle Cell
Lymphomas: Impact of Recurrent Card11
Mutations.” Oncotarget 7 (25): 38180–90. https://doi.org/10.18632/oncotarget.9500.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee,
Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013.
“Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the
National Academy of Sciences of the United States of America 110:
1398–1403. https://doi.org/10.1073/pnas.1205299110.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena
Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic
Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically
Determined Chromatin State of Normal B Cells.”
Blood 123 (19): 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George
Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019.
“Sporadic and Endemic Burkitt Lymphoma Have Frequent
Foxo1 Mutations but Distinct Hotspots in the
AKT Recognition Motif.” Blood Advances 3
(14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.


