DLBCL genes

Origins of DLBCL genessankey

Tier 1 DLBCL genes

Gene Tier Relevant references
ACTB 1 (Lohr et al. 2012)
ACTG1 1 (Hübschmann et al. 2021)
ARID1A 1 (Krysiak et al. 2017; Zhang et al. 2013; Love et al. 2012)
ATM 1 (Reddy et al. 2017)
B2M 1 (Morin et al. 2011)
BCL10 1 (Russler-Germain et al. 2023; Morin et al. 2011)
BCL11A 1 []
BCL2 1 (Morin et al. 2011; Burkhardt et al. 2022; Tanaka et al. 1992)
BCL6 1 (Love et al. 2012; Morin et al. 2011)
BCL7A 1 (Grande et al. 2019; Krysiak et al. 2017; Arthur et al. 2018)
BCOR 1 []
BCR 1 []
BIRC6 1 (Reddy et al. 2017)
BRAF 1 (Tiacci et al. 2011; Love et al. 2012)
BTG1 1 (Burkhardt et al. 2022; Morin et al. 2011)
BTG2 1 (Love et al. 2012; Morin et al. 2011)
BTK 1 (Krysiak et al. 2017; Albuquerque et al. 2017)
CARD11 1 (Lenz et al. 2008; Morin et al. 2011; Panea et al. 2019)
CASP8 1 (Reddy et al. 2017)
CCND3 1 (Morin et al. 2011; Richter et al. 2012)
CD274 1 (Morin et al. 2011)
CD36 1 (Laura Pasqualucci, Trifonov, et al. 2011)
CD58 1 (Morin et al. 2011)
CD70 1 (Morin et al. 2011; Russler-Germain et al. 2023)
CD79B 1 (Panea et al. 2019; Morin et al. 2011)
CD83 1 (Morin et al. 2013; Russler-Germain et al. 2023; Panea et al. 2019)
CDKN2A 1 (Grande et al. 2019; Morin et al. 2013)
CIITA 1 (Morin et al. 2011)
CREBBP 1 (Love et al. 2012; Laura Pasqualucci, Dominguez-Sola, et al. 2011)
CXCR4 1 (Panea et al. 2019; Khodabakhshi et al. 2012; Krysiak et al. 2017)
CXCR5 1 (Schmitz et al. 2018)
DAZAP1 1 (Pararajalingam et al. 2020)
DDX3X 1 (Schmitz et al. 2012, 2018)
DTX1 1 (Panea et al. 2019; Schmitz et al. 2018)
DUSP2 1 (Morin et al. 2013)
EBF1 1 (Bohle et al. 2013; Thomas et al. 2023)
EEF1A1 1 (Hübschmann et al. 2021)
EP300 1 (Panea et al. 2019; Laura Pasqualucci, Dominguez-Sola, et al. 2011)
ETS1 1 (Morin et al. 2011; Panea et al. 2019)
ETV6 1 (Arthur et al. 2018)
EZH2 1 (Morin et al. 2010; Love et al. 2012)
FAS 1 (Scholl et al. 2007)
FBXO11 1 (Richter et al. 2012; Hübschmann et al. 2021)
FBXW7 1 (Zhang et al. 2013)
FOXC1 1 (Schmitz et al. 2018)
FOXO1 1 (Morin et al. 2011; Schmitz et al. 2012)
GNA13 1 (Love et al. 2012; Morin et al. 2011)
GNAI2 1 (Grande et al. 2019; Morin et al. 2013)
GRB2 1 (Laura Pasqualucci, Trifonov, et al. 2011; Panea et al. 2019)
GRHPR 1 (Arthur et al. 2018)
HIST1H1B 1 (Krysiak et al. 2017; Chapuy et al. 2018)
HIST1H1C 1 (Morin et al. 2011; Panea et al. 2019)
HIST1H1D 1 (Morin et al. 2013; Krysiak et al. 2017)
HIST1H1E 1 (Morin et al. 2013; Grande et al. 2019; Krysiak et al. 2017)
HIST1H2AC 1 (Morin et al. 2013; Krysiak et al. 2017)
HIST1H2AM 1 (Panea et al. 2019; Krysiak et al. 2017)
HIST1H2BC 1 (Reddy et al. 2017; Krysiak et al. 2017)
HIST1H2BK 1 (Panea et al. 2019)
HIST1H3B 1 (Zhang et al. 2013)
HIST2H2BE 1 (Schmitz et al. 2018)
HLA-A 1 []
HLA-B 1 []
HLA-C 1 []
HLA-DMA 1 []
HLA-DMB 1 []
HLA-DQA1 1 (Hübschmann et al. 2021)
HNRNPD 1 []
HNRNPH1 1 (Pararajalingam et al. 2020)
HNRNPU 1 (Reddy et al. 2017; Panea et al. 2019)
HVCN1 1 (Krysiak et al. 2017)
IKZF3 1 (Morin et al. 2013; Panea et al. 2019)
IL16 1 []
IL4R 1 (Duns et al. 2021)
IRF4 1 (Morin et al. 2011)
IRF8 1 (Morin et al. 2011; Panea et al. 2019)
ITPKB 1 (Schmitz et al. 2018)
JUNB 1 (Reddy et al. 2017)
KLF2 1 (Laura Pasqualucci, Trifonov, et al. 2011)
KLHL14 1 (Zhang et al. 2013)
KLHL6 1 (Morin et al. 2011; Panea et al. 2019)
KMT2C 1 (Zhang et al. 2013; Zhou et al. 2019)
KMT2D 1 (Morin et al. 2011; Grande et al. 2019)
KRAS 1 (Lohr et al. 2012)
LCOR 1 (Arthur et al. 2018)
LTB 1 (Chapuy et al. 2018; Panea et al. 2019)
LYN 1 (Chapuy et al. 2018)
MCL1 1 (Reddy et al. 2017; Panea et al. 2019)
MEF2B 1 (Morin et al. 2011)
MEF2C 1 (Arthur et al. 2018)
MGA 1 (Zhang et al. 2013)
MPEG1 1 (Morin et al. 2013)
MS4A1 1 (Rushton et al. 2020)
MTOR 1 (Panea et al. 2019; Zhang et al. 2013)
MYC 1 (Johnston and Carroll 1992; L. Pasqualucci et al. 2001)
MYD88 1 (Ngo et al. 2011)
MYOM2 1 (Laura Pasqualucci, Trifonov, et al. 2011)
NCOR2 1 (Schmitz et al. 2012)
NFKB1 1 []
NFKBIA 1 (Russler-Germain et al. 2023; Lake et al. 2009)
NFKBIE 1 (Morin et al. 2016)
NFKBIZ 1 (Morin et al. 2016)
NLRC5 1 []
NOL9 1 (Schmitz et al. 2018)
NOTCH1 1 (Love et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011)
NOTCH2 1 (Panea et al. 2019; Trøen et al. 2008)
OSBPL10 1 (Arthur et al. 2018)
P2RY8 1 (Muppidi et al. 2014; Lohr et al. 2012)
PCBP1 1 (Schmitz et al. 2012)
PIM1 1 (Burkhardt et al. 2022; L. Pasqualucci et al. 2001)
PIM2 1 (Arthur et al. 2018)
POU2AF1 1 (Krysiak et al. 2017)
POU2F2 1 (Zhang et al. 2013; Krysiak et al. 2017)
PRDM1 1 (Laura Pasqualucci et al. 2006)
PRKDC 1 (Schmitz et al. 2018; Hübschmann et al. 2021)
PTEN 1 (Love et al. 2012)
PTPRD 1 []
RB1 1 (Morin et al. 2013)
RFX7 1 (Grande et al. 2019)
RFXAP 1 []
RHOA 1 (Richter et al. 2012)
RRAGC 1 (Okosun et al. 2016)
S1PR2 1 (Muppidi et al. 2014; Morin et al. 2011)
SETD1B 1 (Reddy et al. 2017)
SF3B1 1 (Love et al. 2012)
SGK1 1 (Morin et al. 2011)
SIN3A 1 (Grande et al. 2019)
SMARCA4 1 (Zhang et al. 2013; Krysiak et al. 2017; Richter et al. 2012)
SOCS1 1 (Morin et al. 2011)
SPEN 1 (Rossi et al. 2012)
STAT3 1 (Ohgami et al. 2014)
STAT6 1 (Yildiz et al. 2015)
TAF1 1 (Morin et al. 2013)
TBL1XR1 1 (Mareschal et al. 2016)
TET2 1 (Panea et al. 2019; Albuquerque et al. 2017)
TMEM30A 1 (Morin et al. 2011)
TMSB4X 1 (Albuquerque et al. 2017)
TNFAIP3 1 (Compagno et al. 2009)
TNFRSF14 1 (Cheung et al. 2010)
TOX 1 (Reddy et al. 2017)
TP53 1 (Wilda et al. 2004; Morin et al. 2011)
TRIP12 1 []
TRRAP 1 (Parry et al. 2013)
UBE2A 1 (Reddy et al. 2017)
UNC5C 1 []
USP7 1 (Grande et al. 2019)
VPS13B 1 []
WEE1 1 (Schmitz et al. 2018)
XPO1 1 (Mareschal et al. 2016)
ZC3H12A 1 (Arthur et al. 2018)
ZFP36L1 1 (Panea et al. 2019; Morin et al. 2011)
ZNF292 1 (Zhang et al. 2013)
ZNF608 1 (Krysiak et al. 2017; Zhang et al. 2013)

Tier 2 DLBCL genes

Gene Tier Relevant references
ABI3BP 2 (Morin et al. 2013)
ADAMTS1 2 (Hübschmann et al. 2021)
AICDA 2 (Arthur et al. 2018)
ANKRD12 2 (Hübschmann et al. 2021)
ANKRD17 2 (Reddy et al. 2017)
ARID1B 2 (Reddy et al. 2017)
ARID5B 2 (Reddy et al. 2017)
ATR 2 (Reddy et al. 2017)
BIRC3 2 (Arthur et al. 2018)
BLK 2 []
BRINP3 2 (Reddy et al. 2017)
BTBD3 2 (Reddy et al. 2017)
CADPS2 2 (Hübschmann et al. 2021)
CBLB 2 (Reddy et al. 2017)
CCL4 2 (Chapuy et al. 2018)
CD22 2 (Reddy et al. 2017)
CD44 2 (Arthur et al. 2018)
CD74 2 (Arthur et al. 2018)
CDC73 2 (Love et al. 2012; Reddy et al. 2017)
CDH9 2 (Morin et al. 2013)
CHD1 2 (Reddy et al. 2017)
CHD8 2 (Grande et al. 2019; Reddy et al. 2017)
CHST2 2 (Reddy et al. 2017)
CNOT2 2 (Hübschmann et al. 2021)
CNTNAP5 2 (Morin et al. 2013)
COQ7 2 (Chapuy et al. 2018)
CRIP1 2 (Chapuy et al. 2018)
DCAF6 2 (Reddy et al. 2017)
DDX10 2 (Reddy et al. 2017)
DHX16 2 (Hübschmann et al. 2021)
DICER1 2 (Reddy et al. 2017)
DNAH5 2 (Morin et al. 2013)
DNM2 2 (Hübschmann et al. 2021)
DNMT3A 2 (Reddy et al. 2017)
DOCK1 2 (Chapuy et al. 2018)
DSG4 2 (Morin et al. 2013)
EIF2AK3 2 []
EZR 2 []
FAM102A 2 []
FAM38B 2 (Morin et al. 2013)
FANK1 2 []
FAT4 2 (Morin et al. 2013)
FCRL3 2 []
FNBP1 2 []
FNDC1 2 (Morin et al. 2013)
FOXP1 2 (Reddy et al. 2017)
FUBP1 2 (Reddy et al. 2017)
FUT5 2 (Chapuy et al. 2018)
GABRA2 2 (Chapuy et al. 2018)
GAK 2 (Hübschmann et al. 2021)
GNAS 2 (Reddy et al. 2017)
GOLGA5 2 (Reddy et al. 2017)
GPC5 2 (Schmitz et al. 2018)
GSG2 2 (Schmitz et al. 2018)
HDAC7 2 (Morin et al. 2013)
HIST1H2AG 2 (Morin et al. 2013; Krysiak et al. 2017; Panea et al. 2019)
HNF1B 2 (Laura Pasqualucci, Trifonov, et al. 2011)
HRAS 2 (Reddy et al. 2017)
ID3 2 (Schmitz et al. 2012; Richter et al. 2012)
IER2 2 (Morin et al. 2013)
IFNGR1 2 (Morin et al. 2013)
IGLL5 2 (Panea et al. 2019; Russler-Germain et al. 2023)
IKBKB 2 (Reddy et al. 2017)
IKBKE 2 (Hübschmann et al. 2021)
IL6 2 (Chapuy et al. 2018)
INO80 2 (Zhang et al. 2013)
IRAG2 2 []
IRF1 2 (Hübschmann et al. 2021)
JAK1 2 (Zhang et al. 2013)
JAK3 2 (Zhang et al. 2013)
KCMF1 2 (Reddy et al. 2017)
KLHL21 2 (Schmitz et al. 2018)
LAMA5 2 (Schmitz et al. 2018)
LAPTM5 2 (Hübschmann et al. 2021)
LIN54 2 (Reddy et al. 2017)
LPP 2 (Arthur et al. 2018)
LRP12 2 (Hübschmann et al. 2021)
LRRN3 2 (Morin et al. 2013)
MAGT1 2 (Reddy et al. 2017)
MALAT1 2 (Arthur et al. 2018)
MAP2K1 2 (Shin et al. 2015; Louissaint et al. 2016)
MAP4K4 2 (Reddy et al. 2017)
MARK1 2 (Reddy et al. 2017)
MECOM 2 (Reddy et al. 2017)
MET 2 (Reddy et al. 2017)
MIR142 2 (Kwanhian et al. 2012; Grande et al. 2019)
MIR155HG 2 []
MPDZ 2 (Morin et al. 2013)
MSH2 2 (Reddy et al. 2017)
MSH6 2 (Reddy et al. 2017)
MYB 2 (Reddy et al. 2017)
MYBPC2 2 (Schmitz et al. 2018)
MYO1E 2 []
N2RF2 2 (Hübschmann et al. 2021)
NANOG 2 (Chapuy et al. 2018)
NAV1 2 (Chapuy et al. 2018)
NCOA3 2 []
NCOR1 2 (Reddy et al. 2017)
NEAT1 2 (Arthur et al. 2018)
NF1 2 (Reddy et al. 2017)
NFKB2 2 (Reddy et al. 2017)
NLRP5 2 (Morin et al. 2013)
NLRP8 2 (Chapuy et al. 2018)
ODZ3 2 (Morin et al. 2013)
P2RX5 2 (Morin et al. 2013)
PAPOLG 2 (Schmitz et al. 2018)
PASK 2 (Morin et al. 2013)
PAX5 2 (L. Pasqualucci et al. 2001)
PCDHB11 2 (Morin et al. 2013)
PCLO 2 (Lohr et al. 2012)
PDE4DIP 2 (Chapuy et al. 2018)
PDS5B 2 (Morin et al. 2013; Hübschmann et al. 2021)
PHF6 2 (Thomas et al. 2023; Reddy et al. 2017)
PIK3CD 2 (Reddy et al. 2017)
PIK3R1 2 (Panea et al. 2019; Zhang et al. 2013)
PKD1 2 (Morin et al. 2013)
PNPO 2 (Hübschmann et al. 2021)
POGZ 2 (Morin et al. 2013)
PPP1R9B 2 []
PRKCB 2 (Morin et al. 2013)
PRPS1 2 (Chapuy et al. 2018)
PTMA 2 []
PTPN1 2 []
PTPN23 2 (Morin et al. 2013)
PTPN6 2 (Reddy et al. 2017)
PTPRK 2 (Reddy et al. 2017)
RAC2 2 (Panea et al. 2019; Hübschmann et al. 2021)
RAD9A 2 (Chapuy et al. 2018)
RARA 2 (Reddy et al. 2017)
RCC 2 []
RFTN1 2 (Arthur et al. 2018)
RHEX 2 []
RHOH 2 []
RUBCNL 2 []
RUNX1 2 (Reddy et al. 2017)
SAMD9L 2 (Morin et al. 2013)
SARM1 2 (Morin et al. 2013)
SEL1L3 2 []
SEPTIN9 2 []
SERPINA9 2 (Arthur et al. 2018)
SETD2 2 (Zhang et al. 2013)
SETD5 2 (Reddy et al. 2017)
SIAH2 2 (Hübschmann et al. 2021)
SLC34A2 2 (Hübschmann et al. 2021)
SMEK1 2 (Chapuy et al. 2018)
SRRM2 2 (Morin et al. 2013; Russler-Germain et al. 2023)
ST6GAL1 2 (Arthur et al. 2018)
STAT5B 2 (Zhang et al. 2013)
SYK 2 (Reddy et al. 2017)
SYPL1 2 (Morin et al. 2013)
TAP1 2 (Schmitz et al. 2018)
TBC1D4 2 (Arthur et al. 2018)
TCL1A 2 (Grande et al. 2019)
TGFBR2 2 (Reddy et al. 2017)
TIPARP 2 (Reddy et al. 2017)
TLR2 2 (Chapuy et al. 2018)
TRAF3 2 (Laura Pasqualucci, Trifonov, et al. 2011)
TRAF6 2 (Hübschmann et al. 2021)
UBE2J1 2 []
UBR5 2 (Zhang et al. 2013)
UNC5B 2 (Hübschmann et al. 2021)
UNC5D 2 []
WAC 2 (Reddy et al. 2017)
WDFY3 2 (Morin et al. 2013)
WNK1 2 (Hübschmann et al. 2021; Thomas et al. 2023)
XBP1 2 []
YY1 2 (Reddy et al. 2017)
ZBTB7A 2 (Burkhardt et al. 2022; Reddy et al. 2017)
ZCCHC7 2 (Arthur et al. 2018)
ZEB2 2 (Zhang et al. 2013)
ZFAT 2 (Reddy et al. 2017)
ZFX 2 (Reddy et al. 2017)
ZNF217 2 (Hübschmann et al. 2021)
ZNF423 2 (Chapuy et al. 2018)

References

Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 (5): 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (EBF1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance of Molecular Characteristics in Burkitt Lymphoma Differs According to Age.” Nature Communications 13 (1): 3881. https://doi.org/10.1038/s41467-022-31355-8.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 (5): 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 (22): 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 (7247): 717–21. https://doi.org/10.1038/nature07968.
Duns, Gerben, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021. “Characterization of DLBCL with a PMBL Gene Expression Signature.” Blood 138 (2): 136–48. https://doi.org/10.1182/blood.2020007683.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 (7): 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. “Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717795/.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 (4): 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Kwanhian, Wiyada, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, et al. 2012. “MicroRNA-142 Is Mutated in about 20% of Diffuse Large B-cell Lymphoma.” Cancer Medicine 1 (2): 141–55. https://doi.org/10.1002/cam4.29.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma (DLBCL) by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 (8): 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering EZH2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 (2): 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Muppidi, J., R. Schmitz, Jesse A. Green, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, S. Braun, et al. 2014. “Loss of Signaling via Gα13 in Germinal Center B Cell-Derived Lymphoma.” Nature 516: 254–58. https://doi.org/10.1038/nature13765.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active MYD88 Mutations in Human Lymphoma.” Nature 470 (7332): 115–19. https://doi.org/10.1038/nature09671.
Ohgami, Robert S., Lisa Ma, Ahmad Monabati, James L. Zehnder, and Daniel A. Arber. 2014. “STAT3 Mutations Are Present in Aggressive B-cell Lymphomas Including a Subset of Diffuse Large B-cell Lymphomas with CD30 Expression.” Haematologica 99 (7): e105–107. https://doi.org/10.3324/haematol.2013.101543.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 (2): 183–88. https://doi.org/10.1038/ng.3473.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 (5): 572–84. https://doi.org/10.1182/blood.2019002385.
Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 (12): e83244. https://doi.org/10.1371/journal.pone.0083244.
Pasqualucci, Laura, Mara Compagno, Jane Houldsworth, Stefano Monti, Adina Grunn, Subhadra V Nandula, Jon C Aster, Vundavally V Murty, Margaret A Shipp, and Riccardo Dalla-Favera. 2006. “Inactivation of the PRDM1/BLIMP1 Gene in Diffuse Large B Cell Lymphoma.” J Exp Med 203 (2): 311–17.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 (7337): 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 (6844): 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 (2): 481–494.e15.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 (12): 1316–20. https://doi.org/10.1038/ng.2469.
Rossi, Davide, Vladimir Trifonov, Marco Fangazio, Alessio Bruscaggin, Silvia Rasi, Valeria Spina, Sara Monti, et al. 2012. “The Coding Genome of Splenic Marginal Zone Lymphoma: Activation of NOTCH2 and Other Pathways Regulating Marginal Zone Development.” The Journal of Experimental Medicine 209 (9): 1537–51. https://doi.org/10.1084/jem.20120904.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 (15): 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/CD95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF V600E and MAP2K1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated BCL2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 (8): 904–16. https://doi.org/10.1182/blood.2022016534.
Tiacci, Enrico, Vladimir Trifonov, Gianluca Schiavoni, Antony Holmes, Wolfgang Kern, Maria Paola Martelli, Alessandra Pucciarini, et al. 2011. “BRAF Mutations in Hairy-Cell Leukemia.” The New England Journal of Medicine 364 (24): 2305–15. https://doi.org/10.1056/NEJMoa1014209.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. “NOTCH2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 (7): 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating STAT6 Mutations in Follicular Lymphoma.” Blood 125 (4): 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” January.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent FOXO1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 (14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

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