DLBCL genes

Origins of DLBCL genessankey

Tier 1 DLBCL genes

Gene Tier Relevant references
ACTB 1a (Lohr et al. 2012)
ACTG1 1a (Hübschmann et al. 2021)
ARID1A 1 (Krysiak et al. 2017; Love et al. 2012; Zhang et al. 2013)
ATM 1 (Reddy et al. 2017)
B2M 1 (Morin et al. 2011)
BCL10 1 (Morin et al. 2011; Russler-Germain et al. 2023)
BCL11A 1a
BCL2 1a (Tanaka et al. 1992; Morin et al. 2011; Burkhardt et al. 2022)
BCL6 1a (Love et al. 2012; Morin et al. 2011)
BCL7A 1a (Grande et al. 2019; Krysiak et al. 2017; Arthur et al. 2018)
BCOR 1
BCR 1
BIRC6 1 (Reddy et al. 2017)
BRAF 1 (Love et al. 2012; Tiacci et al. 2011)
BTG1 1a (Burkhardt et al. 2022; Morin et al. 2011)
BTG2 1a (Love et al. 2012; Morin et al. 2011)
BTK 1 (Albuquerque et al. 2017; Krysiak et al. 2017)
CARD11 1 (Panea et al. 2019; Morin et al. 2011; Lenz et al. 2008)
CASP8 1 (Reddy et al. 2017)
CCND3 1 (Morin et al. 2011; Richter et al. 2012)
CD274 1 (Morin et al. 2011)
CD36 1 (Laura Pasqualucci, Trifonov, et al. 2011)
CD58 1 (Morin et al. 2011)
CD70 1 (Morin et al. 2011; Russler-Germain et al. 2023)
CD79B 1 (Panea et al. 2019; Morin et al. 2011)
CD83 1a (Russler-Germain et al. 2023; Panea et al. 2019; Morin et al. 2013)
CDKN2A 1 (Grande et al. 2019; Morin et al. 2013)
CIITA 1a (Morin et al. 2011)
CREBBP 1 (Love et al. 2012; Laura Pasqualucci, Dominguez-Sola, et al. 2011)
CXCR4 1a (Khodabakhshi et al. 2012; Panea et al. 2019; Krysiak et al. 2017)
CXCR5 1 (Schmitz et al. 2018)
DAZAP1 1 (Pararajalingam et al. 2020)
DDX3X 1 (Schmitz et al. 2018, 2012)
DTX1 1a (Schmitz et al. 2018; Panea et al. 2019)
DUSP2 1a (Morin et al. 2013)
EBF1 1a (Bohle et al. 2013; Thomas et al. 2023)
EEF1A1 1 (Hübschmann et al. 2021)
EP300 1 (Laura Pasqualucci, Dominguez-Sola, et al. 2011; Panea et al. 2019)
ETS1 1a (Morin et al. 2011; Panea et al. 2019)
ETV6 1a (Arthur et al. 2018)
EZH2 1 (Love et al. 2012; Morin et al. 2010)
FAS 1 (Scholl et al. 2007)
FBXO11 1 (Hübschmann et al. 2021; Richter et al. 2012)
FBXW7 1 (Zhang et al. 2013)
FOXC1 1 (Schmitz et al. 2018)
FOXO1 1 (Schmitz et al. 2012; Morin et al. 2011)
GNA13 1 (Morin et al. 2011; Love et al. 2012)
GNAI2 1 (Morin et al. 2013; Grande et al. 2019)
GRB2 1 (Panea et al. 2019; Laura Pasqualucci, Trifonov, et al. 2011)
GRHPR 1a (Arthur et al. 2018)
HIST1H1B 1a (Chapuy et al. 2018; Krysiak et al. 2017)
HIST1H1C 1a (Panea et al. 2019; Morin et al. 2011)
HIST1H1D 1a (Krysiak et al. 2017; Morin et al. 2013)
HIST1H1E 1a (Grande et al. 2019; Morin et al. 2013; Krysiak et al. 2017)
HIST1H2AC 1a (Morin et al. 2013; Krysiak et al. 2017)
HIST1H2AM 1a (Panea et al. 2019; Krysiak et al. 2017)
HIST1H2BC 1a (Krysiak et al. 2017; Reddy et al. 2017)
HIST1H2BK 1a (Panea et al. 2019)
HIST1H3B 1a (Zhang et al. 2013)
HIST2H2BE 1a (Schmitz et al. 2018)
HLA-A 1
HLA-B 1
HLA-C 1
HLA-DMA 1
HLA-DMB 1
HLA-DQA1 1 (Hübschmann et al. 2021)
HNRNPD 1
HNRNPH1 1 (Pararajalingam et al. 2020)
HNRNPU 1 (Panea et al. 2019; Reddy et al. 2017)
HVCN1 1 (Krysiak et al. 2017)
IKZF3 1 (Panea et al. 2019; Morin et al. 2013)
IL16 1
IL4R 1a (Duns et al. 2021)
IRF4 1a (Morin et al. 2011)
IRF8 1a (Panea et al. 2019; Morin et al. 2011)
ITPKB 1a (Schmitz et al. 2018)
JUNB 1 (Reddy et al. 2017)
KLF2 1a (Laura Pasqualucci, Trifonov, et al. 2011)
KLHL14 1 (Zhang et al. 2013)
KLHL6 1a (Panea et al. 2019; Morin et al. 2011)
KMT2C 1 (Zhou et al. 2019; Zhang et al. 2013)
KMT2D 1 (Grande et al. 2019; Morin et al. 2011)
KRAS 1 (Lohr et al. 2012)
LCOR 1 (Arthur et al. 2018)
LTB 1a (Chapuy et al. 2018; Panea et al. 2019)
LYN 1 (Chapuy et al. 2018)
MCL1 1 (Reddy et al. 2017; Panea et al. 2019)
MEF2B 1a (Morin et al. 2011)
MEF2C 1a (Arthur et al. 2018)
MGA 1 (Zhang et al. 2013)
MPEG1 1 (Morin et al. 2013)
MS4A1 1a (Rushton et al. 2020)
MTOR 1 (Zhang et al. 2013; Panea et al. 2019)
MYC 1a (Johnston and Carroll 1992; L. Pasqualucci et al. 2001)
MYD88 1 (Ngo et al. 2011)
MYOM2 1 (Laura Pasqualucci, Trifonov, et al. 2011)
NCOR2 1 (Schmitz et al. 2012)
NFKB1 1
NFKBIA 1 (Russler-Germain et al. 2023; Lake et al. 2009)
NFKBIE 1 (Morin et al. 2016)
NFKBIZ 1a (Morin et al. 2016)
NLRC5 1
NOL9 1 (Schmitz et al. 2018)
NOTCH1 1 (Love et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011)
NOTCH2 1 (Panea et al. 2019; Trøen et al. 2008)
OSBPL10 1a (Arthur et al. 2018)
P2RY8 1 (Lohr et al. 2012; Muppidi et al. 2014)
PCBP1 1 (Schmitz et al. 2012)
PIM1 1a (Burkhardt et al. 2022; L. Pasqualucci et al. 2001)
PIM2 1a (Arthur et al. 2018)
POU2AF1 1a (Krysiak et al. 2017)
POU2F2 1 (Krysiak et al. 2017; Zhang et al. 2013)
PRDM1 1 (Laura Pasqualucci et al. 2006)
PRKDC 1 (Schmitz et al. 2018; Hübschmann et al. 2021)
PTEN 1 (Love et al. 2012)
PTPRD 1
RB1 1 (Morin et al. 2013)
RFX7 1 (Grande et al. 2019)
RFXAP 1
RHOA 1 (Richter et al. 2012)
RRAGC 1 (Okosun et al. 2016)
S1PR2 1a (Muppidi et al. 2014; Morin et al. 2011)
SETD1B 1 (Reddy et al. 2017)
SF3B1 1 (Love et al. 2012)
SGK1 1a (Morin et al. 2011)
SIN3A 1 (Grande et al. 2019)
SMARCA4 1 (Richter et al. 2012; Krysiak et al. 2017; Zhang et al. 2013)
SOCS1 1a (Morin et al. 2011)
SPEN 1 (Rossi et al. 2012)
STAT3 1 (Ohgami et al. 2014)
STAT6 1 (Yildiz et al. 2015)
TAF1 1 (Morin et al. 2013)
TBL1XR1 1 (Mareschal et al. 2016)
TET2 1 (Albuquerque et al. 2017; Panea et al. 2019)
TMEM30A 1 (Morin et al. 2011)
TMSB4X 1a (Albuquerque et al. 2017)
TNFAIP3 1 (Compagno et al. 2009)
TNFRSF14 1 (Cheung et al. 2010)
TOX 1 (Reddy et al. 2017)
TP53 1 (Morin et al. 2011; Wilda et al. 2004)
TRIP12 1
TRRAP 1 (Parry et al. 2013)
UBE2A 1 (Reddy et al. 2017)
UNC5C 1
USP7 1 (Grande et al. 2019)
VPS13B 1
WEE1 1 (Schmitz et al. 2018)
XPO1 1 (Mareschal et al. 2016)
ZC3H12A 1 (Arthur et al. 2018)
ZFP36L1 1a (Panea et al. 2019; Morin et al. 2011)
ZNF292 1 (Zhang et al. 2013)
ZNF608 1 (Krysiak et al. 2017; Zhang et al. 2013)

Tier 2 DLBCL genes

Gene Tier Relevant references
ABI3BP 2 (Morin et al. 2013)
ADAMTS1 2 (Hübschmann et al. 2021)
AICDA 2a (Arthur et al. 2018)
ANKRD12 2 (Hübschmann et al. 2021)
ANKRD17 2 (Reddy et al. 2017)
ARID1B 2 (Reddy et al. 2017)
ARID5B 2 (Reddy et al. 2017)
ATR 2 (Reddy et al. 2017)
BIRC3 2a (Arthur et al. 2018)
BLK 2a
BRINP3 2 (Reddy et al. 2017)
BTBD3 2 (Reddy et al. 2017)
CADPS2 2 (Hübschmann et al. 2021)
CBLB 2 (Reddy et al. 2017)
CCL4 2 (Chapuy et al. 2018)
CD22 2 (Reddy et al. 2017)
CD44 2a (Arthur et al. 2018)
CD74 2a (Arthur et al. 2018)
CDC73 2 (Love et al. 2012; Reddy et al. 2017)
CDH9 2 (Morin et al. 2013)
CHD1 2 (Reddy et al. 2017)
CHD8 2 (Grande et al. 2019; Reddy et al. 2017)
CHST2 2 (Reddy et al. 2017)
CNOT2 2 (Hübschmann et al. 2021)
CNTNAP5 2 (Morin et al. 2013)
COQ7 2 (Chapuy et al. 2018)
CRIP1 2 (Chapuy et al. 2018)
DCAF6 2 (Reddy et al. 2017)
DDX10 2 (Reddy et al. 2017)
DHX16 2 (Hübschmann et al. 2021)
DICER1 2 (Reddy et al. 2017)
DNAH5 2 (Morin et al. 2013)
DNM2 2 (Hübschmann et al. 2021)
DNMT3A 2 (Reddy et al. 2017)
DOCK1 2 (Chapuy et al. 2018)
DSG4 2 (Morin et al. 2013)
EIF2AK3 2a
EZR 2a
FAM102A 2a
FAM38B 2 (Morin et al. 2013)
FANK1 2a
FAT4 2 (Morin et al. 2013)
FCRL3 2a
FNBP1 2a
FNDC1 2 (Morin et al. 2013)
FOXP1 2a (Reddy et al. 2017)
FUBP1 2 (Reddy et al. 2017)
FUT5 2 (Chapuy et al. 2018)
GABRA2 2 (Chapuy et al. 2018)
GAK 2 (Hübschmann et al. 2021)
GNAS 2 (Reddy et al. 2017)
GOLGA5 2 (Reddy et al. 2017)
GPC5 2 (Schmitz et al. 2018)
GSG2 2 (Schmitz et al. 2018)
HDAC7 2 (Morin et al. 2013)
HIST1H2AG 2 (Panea et al. 2019; Krysiak et al. 2017; Morin et al. 2013)
HNF1B 2 (Laura Pasqualucci, Trifonov, et al. 2011)
HRAS 2 (Reddy et al. 2017)
ID3 2 (Richter et al. 2012; Schmitz et al. 2012)
IER2 2 (Morin et al. 2013)
IFNGR1 2 (Morin et al. 2013)
IGLL5 2a (Panea et al. 2019; Russler-Germain et al. 2023)
IKBKB 2 (Reddy et al. 2017)
IKBKE 2 (Hübschmann et al. 2021)
IL6 2 (Chapuy et al. 2018)
INO80 2 (Zhang et al. 2013)
IRAG2 2a
IRF1 2a (Hübschmann et al. 2021)
JAK1 2 (Zhang et al. 2013)
JAK3 2 (Zhang et al. 2013)
KCMF1 2 (Reddy et al. 2017)
KLHL21 2 (Schmitz et al. 2018)
LAMA5 2 (Schmitz et al. 2018)
LAPTM5 2a (Hübschmann et al. 2021)
LIN54 2 (Reddy et al. 2017)
LPP 2a (Arthur et al. 2018)
LRP12 2 (Hübschmann et al. 2021)
LRRN3 2 (Morin et al. 2013)
MAGT1 2 (Reddy et al. 2017)
MALAT1 2a (Arthur et al. 2018)
MAP2K1 2 (Louissaint et al. 2016; Shin et al. 2015)
MAP4K4 2 (Reddy et al. 2017)
MARK1 2 (Reddy et al. 2017)
MECOM 2 (Reddy et al. 2017)
MET 2 (Reddy et al. 2017)
MIR142 2a (Kwanhian et al. 2012; Grande et al. 2019)
MIR155HG 2a
MPDZ 2 (Morin et al. 2013)
MSH2 2 (Reddy et al. 2017)
MSH6 2 (Reddy et al. 2017)
MYB 2 (Reddy et al. 2017)
MYBPC2 2 (Schmitz et al. 2018)
MYO1E 2a
N2RF2 2 (Hübschmann et al. 2021)
NANOG 2 (Chapuy et al. 2018)
NAV1 2 (Chapuy et al. 2018)
NCOA3 2a
NCOR1 2 (Reddy et al. 2017)
NEAT1 2a (Arthur et al. 2018)
NF1 2 (Reddy et al. 2017)
NFKB2 2 (Reddy et al. 2017)
NLRP5 2 (Morin et al. 2013)
NLRP8 2 (Chapuy et al. 2018)
ODZ3 2 (Morin et al. 2013)
P2RX5 2a (Morin et al. 2013)
PAPOLG 2 (Schmitz et al. 2018)
PASK 2 (Morin et al. 2013)
PAX5 2a (L. Pasqualucci et al. 2001)
PCDHB11 2 (Morin et al. 2013)
PCLO 2 (Lohr et al. 2012)
PDE4DIP 2 (Chapuy et al. 2018)
PDS5B 2 (Hübschmann et al. 2021; Morin et al. 2013)
PHF6 2 (Thomas et al. 2023; Reddy et al. 2017)
PIK3CD 2 (Reddy et al. 2017)
PIK3R1 2 (Zhang et al. 2013; Panea et al. 2019)
PKD1 2 (Morin et al. 2013)
PNPO 2 (Hübschmann et al. 2021)
POGZ 2 (Morin et al. 2013)
PPP1R9B 2
PRKCB 2 (Morin et al. 2013)
PRPS1 2 (Chapuy et al. 2018)
PTMA 2a
PTPN1 2a
PTPN23 2 (Morin et al. 2013)
PTPN6 2 (Reddy et al. 2017)
PTPRK 2 (Reddy et al. 2017)
RAC2 2 (Hübschmann et al. 2021; Panea et al. 2019)
RAD9A 2 (Chapuy et al. 2018)
RARA 2 (Reddy et al. 2017)
RCC 2a
RFTN1 2a (Arthur et al. 2018)
RHEX 2a
RHOH 2a (L. Pasqualucci et al. 2001)
RUBCNL 2a
RUNX1 2 (Reddy et al. 2017)
SAMD9L 2 (Morin et al. 2013)
SARM1 2 (Morin et al. 2013)
SEL1L3 2a
SEPTIN9 2a
SERPINA9 2a (Arthur et al. 2018)
SETD2 2 (Zhang et al. 2013)
SETD5 2 (Reddy et al. 2017)
SIAH2 2 (Hübschmann et al. 2021)
SLC34A2 2 (Hübschmann et al. 2021)
SMEK1 2 (Chapuy et al. 2018)
SRRM2 2 (Russler-Germain et al. 2023; Morin et al. 2013)
ST6GAL1 2a (Arthur et al. 2018)
STAT5B 2 (Zhang et al. 2013)
SYK 2 (Reddy et al. 2017)
SYPL1 2 (Morin et al. 2013)
TAP1 2 (Schmitz et al. 2018)
TBC1D4 2a (Arthur et al. 2018)
TCL1A 2a (Grande et al. 2019)
TGFBR2 2 (Reddy et al. 2017)
TIPARP 2 (Reddy et al. 2017)
TLR2 2 (Chapuy et al. 2018)
TRAF3 2 (Laura Pasqualucci, Trifonov, et al. 2011)
TRAF6 2 (Hübschmann et al. 2021)
UBE2J1 2a
UBR5 2 (Zhang et al. 2013)
UNC5B 2 (Hübschmann et al. 2021)
UNC5D 2
WAC 2 (Reddy et al. 2017)
WDFY3 2 (Morin et al. 2013)
WNK1 2 (Thomas et al. 2023; Hübschmann et al. 2021)
XBP1 2a
YY1 2 (Reddy et al. 2017)
ZBTB7A 2 (Reddy et al. 2017; Burkhardt et al. 2022)
ZCCHC7 2a (Arthur et al. 2018)
ZEB2 2 (Zhang et al. 2013)
ZFAT 2 (Reddy et al. 2017)
ZFX 2 (Reddy et al. 2017)
ZNF217 2 (Hübschmann et al. 2021)
ZNF423 2 (Chapuy et al. 2018)

References

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