DOCK1
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.82 |
| DLBCL | Schmitz cohort | 10.21 |
| DLBCL | Reddy cohort | 4.90 |
| DLBCL | Chapuy cohort | 5.98 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.528 | 0 |
| DLBCL | No | No | 1.001 | 0 |
| FL | No | No | 1.838 | 0 |
[!NOTE] First described in DLBCL in 2018 by Chapuy B
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## DOCK1
Expression 
## References 1.
Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence
MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD,
Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM,
Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van
Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM,
Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R,
Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh
M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B
cell lymphoma are associated with distinct pathogenic mechanisms and
outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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