Table of Contents
Relevance tier by entity
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Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.82 |
| DLBCL | Schmitz cohort | 10.21 |
| DLBCL | Reddy cohort | 4.90 |
| DLBCL | Chapuy cohort | 5.98 |
Mutation pattern and selective pressure estimates
| Entity | Missense dN/dS | Nonsense dN/dS | Q value |
|---|---|---|---|
| BL | 0.5897 | 0.0000 | 1.0000 |
| FL | 1.5296 | 1.4953 | 1.0000 |
| DLBCL | 0.0000 | 0.0000 | 0.9986 |
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Expression
All Mutations
DLBCL-RICOVER_107-Tumor DLBCL-RICOVER_253-Tumor DLBCL-RICOVER_299-Tumor DLBCL-RICOVER_338-Tumor DLBCL-RICOVER_522-Tumor DLBCL-RICOVER_773-Tumor DLBCL-RICOVER_977-Tumor
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References
1.
Chapuy B, Stewart C, Dunford AJ, Kim J,
Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger
AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A,
Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M,
Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan
JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub
TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler
M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of
diffuse large B cell lymphoma are associated with distinct
pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690.
PMCID: PMC6613387