Table of Contents
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| 2 | relevance in FL not firmly established1 | |
| 2 | relevance in MZL not firmly established2 | |
| 2 | relevance in PMBL/cHL/GZL not firmly established3 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL Exome | 3.448 |
| BL | GAMBL Genome | 0.386 |
| DLBCL | GAMBL Exome | 4.69 |
| DLBCL | GAMBL Genome | 3.571 |
| FL | GAMBL Exome | 3.152 |
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References
1.
Krysiak K, Gomez F, White BS, Matlock M, Miller
CA, Trani L, Fronick CC, Fulton RS, Kreisel F, Cashen AF, Carson KR,
Berrien-Elliott MM, Bartlett NL, Griffith M, Griffith OL, Fehniger TA.
Recurrent somatic mutations affecting B-cell
receptor signaling pathway genes in follicular lymphoma. Blood. 2017 Jan
26;129(4):473–483. PMCID: PMC5270390
2.
Rossi D, Trifonov V, Fangazio M, Bruscaggin A,
Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C,
Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A,
Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R,
Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti
F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R,
Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome
of splenic marginal zone lymphoma: Activation of NOTCH2 and
other pathways regulating marginal zone development. J Exp Med. 2012 Aug
27;209(9):1537–1551. PMCID: PMC3428941
3.
Reichel J, Chadburn A, Rubinstein PG,
Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J, Inghirami G,
Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O, Cesarman E,
Roshal M. Flow
sorting and exome sequencing reveal the oncogenome of primary
Hodgkin and Reed-Sternberg cells. Blood.
2015 Feb 12;125(7):1061–1072.