Table of Contents

Relevance tier by entity

Entity Tier Description
BL 3 Mutations are unlikely to be relevant to BL

Warnings

The variants reported in this gene failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 0 0 [0,0]
BL GAMBL without ICGC/Zhou 320 0 0 [0,0]
BL GAMBL with Panea 410 0 0 [0,0]
BL BLGSP 219 0 0 [0,0]
BL Zhou/ICGC 90 0 0 [0,0]
BL Panea 101 0 0 [0,0]

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 12 0.0110 [0.0048,0.0172]
DLBCL GAMBL with Reddy 2,088 21 0.0101 [0.0058,0.0143]
DLBCL BC 231 0 0.0004 [0,0.0031]
DLBCL Dana-Farber 303 1 0.0033 [0,0.0098]
DLBCL NCI 470 10 0.0213 [0.0082,0.0343]
DLBCL Reddy 999 9 0.0090 [0.0031,0.0149]
DLBCL DLBCL_ICGC 85 1 0.0118 [0,0.0347]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 5 0.0078 [0.001,0.0146]
FL GAMBL with Crouch 1,189 5 0.0042 [5e-04,0.0079]
FL BC 379 1 0.0026 [0,0.0078]
FL Kalmbach 164 4 0.0244 [8e-04,0.048]
FL Crouch 547 0 0.0002 [0,0.0013]
FL FL_ICGC 99 0 0.0010 [0,0.0073]

Mutation pattern and selective pressure estimates

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Representative Mutations

Rating ★ ★ ☆ ☆ ☆

All Mutations

1061 1063 1092 475

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References

1.
Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

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