FAS
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| BL | 2 | relevance in BL not firmly established |
| DLBCL | 1 | high-confidence DLBCL gene |
| FL | 1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 2.08 |
| BL | Thomas cohort | 1.70 |
| BL | Panea cohort | 4.00 |
| DLBCL | GAMBL genomes | 9.18 |
| DLBCL | Schmitz cohort | 10.85 |
| DLBCL | Reddy cohort | 4.70 |
| DLBCL | Chapuy cohort | 8.97 |
| FL | GAMBL genomes | 5.08 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 6.699 | 0.000 |
| DLBCL | No | Yes | 16.878 | 179.289 |
| FL | No | Yes | 0.000 | 176.866 |
[!NOTE] First described in DLBCL in 2007 by Scholl V. First described in FL in 2011 by Morin RD
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
