FAT4
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | relevance in MZL not firmly established |
 |
2 | relevance in DLBCL not firmly established |
 |
2 | relevance in MCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 12.81 |
| DLBCL | Schmitz cohort | 20.43 |
| DLBCL | Reddy cohort | 14.91 |
| DLBCL | Chapuy cohort | 16.67 |
| MCL | GAMBL genomes | 3.79 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 1.682 | 4.189 |
| FL | No | No | 0.000 | 0.000 |
[!NOTE] First described in DLBCL in 2013 by Morin RD. First described in MCL in 2014 by Zhang J
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## FAT4
Expression 