FL genes

Gene Tier FL Relevant references
ABL2 2 (Russler-Germain et al. 2023)
ACTB 1 (Lohr et al. 2012)
ACTG1 2 (Hübschmann et al. 2021)
ARID1A 1 (Krysiak et al. 2017; Zhang et al. 2013)
ATP6AP1 1 (Okosun et al. 2016)
ATP6V1A 2 (Hübschmann et al. 2021)
ATP6V1B2 1 (Okosun et al. 2016)
B2M 1 (Morin et al. 2011)
BCL10 2 (Russler-Germain et al. 2023; Morin et al. 2011)
BCL2 1 (Morin et al. 2011; Tanaka et al. 1992)
BCL6 1 (Morin et al. 2011)
BCL7A 1 (Krysiak et al. 2017; Arthur et al. 2018)
BIRC6 1 (Reddy et al. 2017)
BTG1 1 (Morin et al. 2011)
BTG2 1 (Morin et al. 2011)
BTK 1 (Krysiak et al. 2017; Albuquerque et al. 2017)
CARD11 1 (Morin et al. 2011; Lenz et al. 2008)
CCDC42BPB 2 (Hübschmann et al. 2021)
CCND3 1 (Morin et al. 2011)
CD70 2 (Russler-Germain et al. 2023; Morin et al. 2011)
CD79B 2 (Morin et al. 2011)
CD83 1 (Russler-Germain et al. 2023; Morin et al. 2013)
CILP 2 (Russler-Germain et al. 2023)
CPNE8 2 (Hübschmann et al. 2021)
CREBBP 1 (Laura Pasqualucci, Dominguez-Sola, et al. 2011)
CTSS 1 (Bararia et al. 2020)
CXCR4 2 (Krysiak et al. 2017; Khodabakhshi et al. 2012)
CYP2A6 2 (Russler-Germain et al. 2023)
DDX3X 2 (Schmitz et al. 2018)
DHX15 2 (Hübschmann et al. 2021)
DTX1 1 (Schmitz et al. 2018)
DUSP2 2 (Morin et al. 2013)
EBF1 1 (Bohle et al. 2013)
EEF1A1 1 (Hübschmann et al. 2021)
EGR1 2 (Krysiak et al. 2017)
EP300 1 (Laura Pasqualucci, Dominguez-Sola, et al. 2011)
EZH2 1 (Morin et al. 2010)
FAS 1 (Scholl et al. 2007)
FOXO1 1 (Morin et al. 2011)
FZR1 2 (Hübschmann et al. 2021)
GBP7 2 (Russler-Germain et al. 2023)
GNA13 1 (Morin et al. 2011)
GNAI2 1 (Morin et al. 2013)
GRM6 2 (Russler-Germain et al. 2023)
HIST1H1B 1 (Krysiak et al. 2017; Chapuy et al. 2018)
HIST1H1C 1 (Morin et al. 2011)
HIST1H1D 1 (Krysiak et al. 2017; Morin et al. 2013)
HIST1H1E 1 (Krysiak et al. 2017; Morin et al. 2013)
HIST1H2AC 1 (Krysiak et al. 2017; Morin et al. 2013)
HIST1H2AG 1 (Krysiak et al. 2017; Morin et al. 2013)
HIST1H2AM 1 (Krysiak et al. 2017)
HIST1H2BC 1 (Krysiak et al. 2017; Reddy et al. 2017)
HIST1H2BD 1 (Krysiak et al. 2017)
HIST1H2BG 1 (Krysiak et al. 2017)
HIST1H2BM 2 (Krysiak et al. 2017)
HIST1H3B 1 (Zhang et al. 2013)
HIST1H3G 1 (Krysiak et al. 2017)
HIST1H3I 2 (Krysiak et al. 2017)
HLA-B 2
HNRNPD 2
HVCN1 1 (Krysiak et al. 2017)
IGLL5 2 (Russler-Germain et al. 2023)
IRF4 1 (Morin et al. 2011)
IRF8 1 (Morin et al. 2011)
ITPKB 1 (Schmitz et al. 2018)
JUP 2 (Hübschmann et al. 2021)
KIR3DL1 2 (Russler-Germain et al. 2023)
KLF2 1 (Laura Pasqualucci, Trifonov, et al. 2011)
KLHL6 1 (Morin et al. 2011)
KMT2D 1 (Morin et al. 2011)
LAPTM5 2 (Hübschmann et al. 2021)
LTB 1 (Chapuy et al. 2018)
MAGEC1 2 (Russler-Germain et al. 2023)
MAP2K1 1 (Louissaint et al. 2016; Shin et al. 2015)
MAP7D1 2 (Russler-Germain et al. 2023)
MEF2B 1 (Morin et al. 2011)
MEF2C 1 (Arthur et al. 2018)
MGEA5 2 (Hübschmann et al. 2021)
MKI67 2 (Russler-Germain et al. 2023)
MYC 2 (L. Pasqualucci et al. 2001)
MYCBP2 2 (Hübschmann et al. 2021)
MYD88 2 (Ngo et al. 2011)
NFKBIA 2 (Russler-Germain et al. 2023; Lake et al. 2009)
OR8H2 2 (Russler-Germain et al. 2023)
P2RY8 2 (Lohr et al. 2012)
PCLO 1 (Lohr et al. 2012)
PDS5B 2 (Hübschmann et al. 2021; Morin et al. 2013)
PIM1 1 (L. Pasqualucci et al. 2001)
POU2AF1 1 (Krysiak et al. 2017)
POU2F2 1 (Krysiak et al. 2017; Zhang et al. 2013)
PPP4C 2 (Hübschmann et al. 2021)
PRKDC 2 (Hübschmann et al. 2021; Schmitz et al. 2018)
PTPRD 1
PZP 2 (Russler-Germain et al. 2023)
RBM6 2 (Hübschmann et al. 2021)
RRAGC 1 (Okosun et al. 2016)
S1PR2 1 (Morin et al. 2011)
SESN1 2 (Oricchio et al. 2017)
SGK1 1 (Morin et al. 2011)
SHROOM3 2 (Russler-Germain et al. 2023)
SMARCA4 1 (Krysiak et al. 2017; Zhang et al. 2013)
SOCS1 1 (Morin et al. 2011)
SRRM2 2 (Russler-Germain et al. 2023; Morin et al. 2013)
STAB2 2 (Russler-Germain et al. 2023)
STAT6 1 (Yildiz et al. 2015)
TBL1XR1 1 (Mareschal et al. 2016)
TMEM30A 2 (Morin et al. 2011)
TMSB4X 1 (Albuquerque et al. 2017)
TNFAIP3 1 (Compagno et al. 2009)
TNFRSF14 1 (Cheung et al. 2010)
TP53 1 (Morin et al. 2011)
TPP1 2 (Hübschmann et al. 2021)
VMA21 1 (Hübschmann et al. 2021)
XIRP2 2 (Russler-Germain et al. 2023)
ZC3H12A 2 (Arthur et al. 2018)
ZNF608 2 (Krysiak et al. 2017; Zhang et al. 2013)

References

Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 (5): 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Bararia, Deepak, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, et al. 2020. “Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.” Cell Reports 31 (5): 107522. https://doi.org/10.1016/j.celrep.2020.107522.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (EBF1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 (5): 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 (22): 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 (7247): 717–21. https://doi.org/10.1038/nature07968.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 (7): 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. “Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717795/.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 (4): 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma (DLBCL) by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 (8): 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering EZH2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 (2): 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active MYD88 Mutations in Human Lymphoma.” Nature 470 (7332): 115–19. https://doi.org/10.1038/nature09671.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 (2): 183–88. https://doi.org/10.1038/ng.3473.
Oricchio, Elisa, Natalya Katanayeva, Maria Christine Donaldson, Stephanie Sungalee, Joyce P. Pasion, Wendy Béguelin, Elena Battistello, et al. 2017. “Genetic and Epigenetic Inactivation of SESTRIN1 Controls mTORC1 and Response to EZH2 Inhibition in Follicular Lymphoma.” Science Translational Medicine 9 (396): eaak9969. https://doi.org/10.1126/scitranslmed.aak9969.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 (7337): 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 (6844): 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 (2): 481–494.e15.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 (15): 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/CD95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. “BRAF V600E and MAP2K1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated BCL2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating STAT6 Mutations in Follicular Lymphoma.” Blood 125 (4): 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” January.