[FOXO1]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 1 |
| DLBCL | 1 |
| FL | 1 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 23.33 |
| BL | Thomas cohort | 28.00 |
| BL | Panea cohort | 21.80 |
| DLBCL | GAMBL genomes | 10.60 |
| DLBCL | Schmitz cohort | 7.20 |
| DLBCL | Reddy cohort | 2.40 |
| DLBCL | Chapuy cohort | 2.10 |
| FL | GAMBL genomes | 12.93 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 14.841 | 5.170 |
| DLBCL | No | No | 6.936 | 0.000 |
| FL | No | Yes | 18.992 | 103.028 |
[!NOTE] First described in BL in 2012 by Schmitz R. First described in DLBCL in 2011 by Morin RD. First described in FL in 2011 by Morin RD
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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