FZR1
History
Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.1
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| FL | 2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| FL | GAMBL genomes | 1.15 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.365 | 0 |
| DLBCL | No | No | 4.444 | 0 |
| FL | No | No | 12.412 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
FZR1 Expression
## References 1. Hübschmann D, Kleinheinz K, Wagener R,
Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H,
Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R,
Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P,
Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S,
Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C,
Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA,
Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P,
Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero
JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A,
Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W,
Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining
consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R.
Mutational mechanisms shaping the coding and noncoding genome of
germinal center derived B-cell lymphomas. Leukemia. 2021
Jul;35(7):2002–2016. PMCID: PMC8257491