Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 3 Mutations are unlikely to be relevant to DLBCL

Warnings

The variants reported in this gene in DLBCL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.29
DLBCL Schmitz cohort 3.19
DLBCL Reddy cohort 1.90
DLBCL Chapuy cohort 1.28

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.1433 7.6788 1.0000
FL 1.3561 0.0000 1.0000
DLBCL 0.0000 0.0000 0.9986

Visualizations

Protein

View coding variants in ProteinPaint hg19 or hg38

Genome

View all variants in GenomePaint hg19 or hg38

Expression

All Mutations

Reddy_2073T Reddy_2095T Reddy_2137T Reddy_2234T Reddy_2253T Reddy_2451T Reddy_2453T Reddy_2479T Reddy_2482T Reddy_2630T Reddy_2639T Reddy_2644T Reddy_2659T Reddy_2775T Reddy_2784T Reddy_2837T Reddy_2838T Reddy_2905T Reddy_2933T Reddy_2999T Reddy_3479T Reddy_3507T Reddy_3523T Reddy_3548T Reddy_3586T Reddy_3602T Reddy_3608T Reddy_3630T Reddy_3636T Reddy_3663T Reddy_3674T Reddy_3712T Reddy_3719T Reddy_3728T Reddy_3742T Reddy_3749T Reddy_3820T Reddy_3834T Reddy_3882T Reddy_3886T Reddy_3913T Reddy_3929T Reddy_3945T Reddy_3977T Reddy_816T

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2017-10-10 : Reddy : DLBCL

References

1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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