[GRB2]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 2 |
| DLBCL | 2 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 0.46 |
| BL | Thomas cohort | 0.40 |
| BL | Panea cohort | 1.00 |
| DLBCL | GAMBL genomes | 3.40 |
| DLBCL | Schmitz cohort | 2.80 |
| DLBCL | Reddy cohort | 1.50 |
| DLBCL | Chapuy cohort | 3.00 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 7.253 | 0.000 |
| DLBCL | No | Yes | 33.029 | 168.982 |
| FL | No | No | 8.575 | 0.000 |
[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2018 by Chapuy B
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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