GRB2

Overview

GRB2 (Growth factor receptor-bound protein 2) is an adaptor protein that links receptor tyrosine kinases to the Ras signaling pathway through its SH2 and SH3 domains. The mutation pattern in DLBCL implies the preferential accumulation of inactivating mutations. While direct evidence of GRB2 mutations in DLBCL is limited, its established role in other cancers and signal transduction pathways suggests that it may contribute to lymphomagenesis. Further research is needed to elucidate its specific role in DLBCL.

Relevance tier by entity

Entity	Tier	Description
DLBCL	1	high-confidence DLBCL gene
BL	2	relevance in BL seems unlikely

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	3.25
DLBCL	Schmitz cohort	2.77
DLBCL	Reddy cohort	1.50
DLBCL	Chapuy cohort	2.99
BL	GAMBL genomes+capture	0.46
BL	Thomas cohort	0.40
BL	Panea cohort	1.00

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
DLBCL	No	Yes	33.029	168.982
FL	No	No	8.575	0.000
BL	No	No	7.253	0.000

[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2011 by Pasqualucci L

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

## GRB2 Expression