Table of Contents

Overview

This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.1,2 Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.

Relevance tier by entity

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Warnings

The variants reported in BL in this gene failed QC

See below or the study page for more information

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 119 0.1093 [0.0907,0.1278]
DLBCL GAMBL with Reddy 2,088 213 0.1020 [0.089,0.115]
DLBCL BC 231 23 0.0996 [0.061,0.1382]
DLBCL Dana-Farber 303 35 0.1155 [0.0795,0.1515]
DLBCL NCI 470 46 0.0979 [0.071,0.1247]
DLBCL Reddy 999 94 0.0941 [0.076,0.1122]
DLBCL DLBCL_ICGC 85 15 0.1765 [0.0954,0.2575]

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 10 0.0308 [0.0116,0.0501]
BL GAMBL without ICGC/Zhou 320 18 0.0461 [0.0233,0.069]
BL GAMBL with Panea 410 20 0.0375 [0.0192,0.0558]
BL BLGSP 219 8 0.0365 [0.0117,0.0614]
BL Zhou/ICGC 90 2 0.0222 [0,0.0527]
BL Panea 101 10 0.0990 [0.0408,0.1573]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 31 0.0483 [0.0317,0.0649]
FL GAMBL with Crouch 1,189 77 0.0648 [0.0508,0.0787]
FL BC 379 17 0.0449 [0.024,0.0657]
FL Kalmbach 164 9 0.0549 [0.02,0.0897]
FL Crouch 547 46 0.0841 [0.0608,0.1074]
FL FL_ICGC 99 5 0.0505 [0.0074,0.0936]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 6.2618 0.0000 0.4495
FL 4.0754 7.5745 0.0044
DLBCL 1.4674 0.3812 0.0032

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History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2011-07-27 : Morin : DLBCL 2019-09-26 : Panea : BL

References

1.
Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554
2.
Crouch S, Painter D, Barrans SL, Roman E, Beer PA, Cooke SL, Glover P, Van Hoppe SJL, Webster N, Lacy SE, Ruiz C, Campbell PJ, Hodson DJ, Patmore R, Burton C, Smith A, Tooze RM. Molecular subclusters of follicular lymphoma: A report from the United Kingdom’s Haematological Malignancy Research Network. Blood Advances [Internet]. 2022 Nov 2 [cited 2024 Nov 18];6(21):5716–5731. Available from: https://doi.org/10.1182/bloodadvances.2021005284
3.
Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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