HIST1H1C

Table of Contents

Overview
Relevance tier by entity
Warnings
Mutation incidence in large patient cohorts (GAMBL reanalysis)
- DLBCL
- BL
- FL
Mutation pattern and selective pressure estimates

Overview

This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.^1,2 Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene
	1	high-confidence DLBCL gene¹
	1	high-confidence FL gene¹
	3	Retired, Failed QC³]

Warnings

The variants reported in BL in this gene failed QC

See below or the study page for more information

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

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BL

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FL

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Mutation pattern and selective pressure estimates

Cannot include /dnds_HIST1H1C.md - does not exist yet

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