HIST1H1E
Overview
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.1,2 Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins. ## Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| BL | 2 | relevance in BL not firmly established |
| DLBCL | 1 | high-confidence DLBCL gene |
| FL | 1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 9.70 |
| BL | Thomas cohort | 7.60 |
| BL | Panea cohort | 19.80 |
| DLBCL | GAMBL genomes | 18.55 |
| DLBCL | Schmitz cohort | 17.87 |
| DLBCL | Reddy cohort | 14.51 |
| DLBCL | Chapuy cohort | 11.54 |
| FL | GAMBL genomes | 12.93 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 14.203 | 0.000 |
| DLBCL | No | Yes | 4.446 | 6.437 |
| FL | No | Yes | 10.043 | 0.000 |
[!NOTE] First described in BL in 2019 by Panea RI
## HIST1H1E Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr6 | 26157090 | G>T | A158S |
| chr6 | 26157096 | A>C | K160Q |
| chr6 | 26157096 | A>G | K160E |
| chr6 | 26157099 | C>G | P161A |
| chr6 | 26157099 | C>T | P161S |
| chr6 | 26157102 | G>A | A162T |
| chr6 | 26157105 | G>A | A163T |
| chr6 | 26157106 | C>T | A163V |
| chr6 | 26157108 | G>A | A164T |
| chr6 | 26157108 | G>C | A164P |
| chr6 | 26157109 | C>G | A164G |
| chr6 | 26157109 | C>T | A164V |
| chr6 | 26157112 | C>G | A165G |
| chr6 | 26157112 | C>T | A165V |
| chr6 | 26157114 | G>A | G166R |
| chr6 | 26157118 | C>T | A167V |
| chr6 | 26157121 | A>T | K168I |
| chr6 | 26157139 | A>G | K174R |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
##
HIST1H1E Expression 
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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