Table of Contents
This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.

Relevance tier by entity

Entity Tier Description
DLBCL 1 high-confidence DLBCL gene1–3
FL 1 high-confidence FL gene4

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 5.16
DLBCL Schmitz cohort 6.17
DLBCL Reddy cohort 3.40
DLBCL Chapuy cohort 6.41
FL GAMBL genomes 2.31

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 1.742 0.000
DLBCL No No 3.090 20.364
FL No No 1.715 0.000

HIST1H2AC Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr6 26124549 G>T R30L
chr6 26124560 CTGCTCCG>- L34*
chr6 26124578 T>G Y40D
chr6 26124581 G>A A41T
chr6 26124690 C>G T77S
chr6 26124709 C>G H83Q
chr6 26124737 G>A E93K
chr6 26124740 C>G L94V
chr6 26124740 C>T L94F
chr6 26124767 A>G I103V
chr6 26124769 T>G I103M
chr6 26124770 G>A A104T
chr6 26124770 G>C A104P
chr6 26124771 C>G A104G
chr6 26124771 C>T A104V
chr6 26124791 A>G N111D
chr6 26124800 G>A A114T
chr6 26124819 A>G K120R
chr6 26124832 CC>TT H125Y

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

HIST1H2AC Expression

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References

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Krysiak K, Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC, Fulton RS, Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL, Griffith M, Griffith OL, Fehniger TA. Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma. Blood. 2017 Jan 26;129(4):473–483. PMCID: PMC5270390

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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