Table of Contents
Overview
This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.
The variants reported in this gene in BL failed QC
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in MZL not firmly established1 |
 |
3 | Retired, Failed QC2 |
 |
1 | high-confidence DLBCL gene3,4 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
Cannot include /DLBCL_HIST1H2BK.md - does not exist yet
BL
Cannot include /BL_HIST1H2BK.md - does not exist yet
FL
Cannot include /FL_HIST1H2BK.md - does not exist yet
Mutation pattern and selective pressure estimates
Cannot include /dnds_HIST1H2BK.md - does not exist yet
Cannot include /browser_HIST1H2BK.md - does not exist yet
1.
Rossi D, Trifonov V, Fangazio M, Bruscaggin A,
Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C,
Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A,
Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R,
Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti
F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R,
Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome
of splenic marginal zone lymphoma: Activation of NOTCH2 and
other pathways regulating marginal zone development. J Exp Med. 2012 Aug
27;209(9):1537–1551. PMCID: PMC3428941
2.
Panea R, Love C, Shingleton JR, Reddy A, Bailey
J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N,
Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles
R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung
R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop
A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S,
Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome
landscape of Burkitt lymphoma subtypes. Blood. 2019;
3.
Zhang J, Grubor V, Love CL, Banerjee A,
Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G,
Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers C,
Naresh K, Evens A, Gordon LI, Czader M, Gill JI, Hsi ED, Liu Q, Fan A,
Walsh K, Jima D, Smith LL, Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J,
Chadburn A, Levy S, Dunson D, Dave SS. Genetic heterogeneity of diffuse
large B-cell lymphoma. Proceedings of the
National Academy of Sciences of the United States of America.
2013;110:1398–1403. PMCID: PMC3557051
4.
Chapuy B, Stewart C, Dunford AJ, Kim J,
Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger
AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A,
Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M,
Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan
JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub
TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler
M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of
diffuse large B cell lymphoma are associated with distinct
pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690.
PMCID: PMC6613387
